Project measure / variable:   CSNA03   infusions_do_0p32

ID, description, units MPD:110265   infusions_do_0p32   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, DO   [n]  0.32 mg/kg  
cocaine study
Data set, strains CSNA03   DO population w/par   8 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

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Plot Options Bins number: (min: 10, max: 40)


Distribution of Individual Animals with Boxplots.





  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means72.13   n 71.95   n
Median of the strain means76.91   n 65.66   n
SD of the strain means± 26.227 ± 28.275
Coefficient of variation (CV)0.3636 0.393
Min–max range of strain means19.0   –   105.9   n 36.186   –   124.0   n
Mean sample size per strain49.2   mice 46.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 40.3166 40.3166 0.0293 0.8642
strain 7 81720.2632 11674.3233 8.4818 < 0.0001
sex:strain 7 9069.9287 1295.7041 0.9414 0.4736
Residuals 747 1028164.9989 1376.3922


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 85.9 59.69   11 17.998 0.6949 10.4, 195.5 0.52
A/J m 101.3 59.63   8 21.084 0.5884 22.667, 214.5 1.04
C57BL/6J f 90.35 26.096   13 7.2378 0.2888 47.0, 132.5 0.69
C57BL/6J m 66.23 22.212   13 6.1604 0.3354 39.5, 117.0 -0.2
CAST/EiJ f 79.04 47.101   5 21.064 0.5959 15.5, 138.0 0.26
CAST/EiJ m 50.2 34.97   4 17.485 0.6966 21.5, 95.5 -0.77
J:DO f 64.89 35.084   325 1.9461 0.5406 2.0, 219.5 -0.28
J:DO m 65.08 38.364   307 2.1895 0.5894 -0.24
NOD/ShiLtJ f 57.2 25.473   13 7.0651 0.4453 13.8, 116.0 -0.57
NOD/ShiLtJ m 58.24 39.001   9 13.0 0.6696 -0.48
NZO/HlLtJ f 74.77 39.943   13 11.078 0.5342 22.5, 162.5 0.1
NZO/HlLtJ m 74.36 25.377   11 7.6515 0.3413 35.0, 113.5 0.09
PWK/PhJ f 105.9 42.025   11 12.671 0.3968 55.5, 181.5 1.29
PWK/PhJ m 124.0 53.64   10 16.961 0.4327 75.0, 256.0 1.84
WSB/EiJ f 19.0 8.3516   3 4.8218 0.4396 10.0, 26.5 -2.03
WSB/EiJ m 36.186 20.824   7 7.8706 0.5755 19.0, 80.5 -1.26


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 85.9 11.1859986918 107.8597349418 63.9402650582
A/J m 101.345875 13.1167461384 127.0959467131 75.5958032869
C57BL/6J f 90.3461538462 10.289622233 110.5461720218 70.1461356706
C57BL/6J m 66.2307692308 10.289622233 86.4307874064 46.0307510552
CAST/EiJ f 79.04 16.591517315 111.6115506104 46.4684493896
CAST/EiJ m 50.2 18.5498802831 86.6161006487 13.7838993513
J:DO f 64.8932307692 2.0579244466 68.9332344044 60.8532271341
J:DO m 65.0847882736 2.1173951747 69.2415415582 60.928034989
NOD/ShiLtJ f 57.2 10.289622233 77.4000181756 36.9999818244
NOD/ShiLtJ m 58.2444444444 12.3665868554 82.5218448769 33.967044012
NZO/HlLtJ f 74.7692307692 10.289622233 94.9692489448 54.5692125936
NZO/HlLtJ m 74.3636363636 11.1859986918 96.3233713054 52.4039014219
PWK/PhJ f 105.9090909091 11.1859986918 127.8688258508 83.9493559673
PWK/PhJ m 123.95 11.7319744036 146.9815643104 100.9184356896
WSB/EiJ f 19.0 21.4195567498 61.0496910248 -23.0496910248
WSB/EiJ m 36.1857142857 14.0223914512 63.7136988672 8.6577297042


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 93.6229375 8.6193908717 110.5440496971 76.7018253029
C57BL/6J both 78.2884615385 7.2758616568 92.5720313705 64.0048917064
CAST/EiJ both 64.62 12.4436379863 89.0486629578 40.1913370422
J:DO both 64.9890095214 1.4763481427 67.8872946713 62.0907243715
NOD/ShiLtJ both 57.7222222222 8.0437677141 73.5133028222 41.9311416223
NZO/HlLtJ both 74.5664335664 7.5993896536 89.4851356967 59.6477314362
PWK/PhJ both 114.9295454545 8.1050260663 130.8408850689 99.0182058402
WSB/EiJ both 27.5928571429 12.8006335133 52.7223540061 2.4633602796




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA