Project measure / variable:   CSNA03   infusions_do_0p56

ID, description, units MPD:110264   infusions_do_0p56   dose response, number of infusions (intravenous self administration), DO   [n]  0.56 mg/kg  
cocaine study
Data set, strains CSNA03   DO population w/par   8 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

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Plot Options Bins number: (min: 10, max: 40)


Distribution of Individual Animals with Boxplots.





  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means54.01   n 49.494   n
Median of the strain means55.73   n 48.967   n
SD of the strain means± 22.624 ± 15.448
Coefficient of variation (CV)0.4189 0.3121
Min–max range of strain means12.75   –   88.5   n 22.929   –   75.77   n
Mean sample size per strain10.8   mice 11.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 716.3729 716.3729 0.8066 0.3705
strain 7 26026.2157 3718.0308 4.1861 0.0003
sex:strain 7 7222.1388 1031.7341 1.1616 0.3278
Residuals 161 142998.25 888.1879


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 59.86 42.502   9 14.167 0.7101 7.0, 122.0 0.26
A/J m 63.15 40.729   8 14.4 0.645 20.5, 148.5 0.88
C57BL/6J f 59.14 20.601   11 6.2115 0.3484 35.0, 104.5 0.23
C57BL/6J m 44.582 10.341   11 3.118 0.232 32.5, 68.0 -0.32
CAST/EiJ f 88.5 49.312   6 20.132 0.5572 36.5, 177.0 1.52
CAST/EiJ m 41.625 15.413   4 7.7065 0.3703 21.0, 58.0 -0.51
J:DO f 46.536 32.066   23 6.6863 0.6891 8.5, 140.0 -0.33
J:DO m 48.223 37.002   30 6.7556 0.7673 5.0, 187.0 -0.08
NOD/ShiLtJ f 52.33 23.075   12 6.6613 0.4409 20.5, 92.0 -0.07
NOD/ShiLtJ m 49.711 31.501   9 10.5 0.6337 11.4, 110.5 0.01
NZO/HlLtJ f 39.769 7.693   13 2.1337 0.1934 28.0, 59.0 -0.63
NZO/HlLtJ m 49.964 20.08   11 6.0544 0.4019 30.5, 98.4 0.03
PWK/PhJ f 73.22 23.509   10 7.434 0.3211 33.5, 112.5 0.85
PWK/PhJ m 75.77 35.445   11 10.687 0.4678 46.5, 161.0 1.7
WSB/EiJ f 12.75 3.8891   2   2.75 0.305 10.0, 15.5 -1.82
WSB/EiJ m 22.929 7.4466   7 2.8146 0.3248 10.0, 33.5 -1.72


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 59.8555555556 9.9341604128 79.4736159234 40.2374951877
A/J m 63.15 10.5367682899 83.9580952798 42.3419047202
C57BL/6J f 59.1363636364 8.9857861899 76.8815669149 41.3911603578
C57BL/6J m 44.5818181818 8.9857861899 62.3270214604 26.8366149032
CAST/EiJ f 88.5 12.1668120171 112.5271188222 64.4728811778
CAST/EiJ m 41.625 14.9012406191 71.0520905518 12.1979094482
J:DO f 46.5360869565 6.2142469128 58.8080320442 34.2641418689
J:DO m 48.2233333333 5.4411637479 58.9685875313 37.4780791353
NOD/ShiLtJ f 52.3333333333 8.6032352827 69.3230719849 35.3435946818
NOD/ShiLtJ m 49.7111111111 9.9341604128 69.329171479 30.0930507432
NZO/HlLtJ f 39.7692307692 8.2657210954 56.0924436727 23.4460178658
NZO/HlLtJ m 49.9636363636 8.9857861899 67.7088396422 32.2184330851
PWK/PhJ f 73.22 9.4243720637 91.8313262112 54.6086737888
PWK/PhJ m 75.7727272727 8.9857861899 93.5179305513 58.0275239941
WSB/EiJ f 12.75 21.0735365798 54.3661905596 -28.8661905596
WSB/EiJ m 22.9285714286 11.2642791156 45.1733609738 0.6837818833


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 61.5027777778 7.2407014353 75.8017735622 47.2037819934
C57BL/6J both 51.8590909091 6.3539103492 64.4068444809 39.3113373373
CAST/EiJ both 65.0625 9.6187094593 84.0576052724 46.0673947276
J:DO both 47.3797101449 4.1298646354 55.5354002447 39.2240200452
NOD/ShiLtJ both 51.0222222222 6.5708294841 63.9983494569 38.0460949875
NZO/HlLtJ both 44.8664335664 6.1046396019 56.9219252496 32.8109418833
PWK/PhJ both 74.4963636364 6.5108206519 87.3539849437 61.638742329
WSB/EiJ both 17.8392857143 11.9475722217 41.4334480145 -5.754876586




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA