Project measure / variable:   CSNA03   infusions_do_1p8

ID, description, units MPD:110263   infusions_do_1p8   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, DO   [n]  1.8 mg/kg  
cocaine study
Data set, strains CSNA03   DO population w/par   8 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

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Plot Options Bins number: (min: 10, max: 40)


Distribution of Individual Animals with Boxplots.





  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means30.022   n 25.19   n
Median of the strain means26.866   n 24.187   n
SD of the strain means± 17.856 ± 7.3958
Coefficient of variation (CV)0.5948 0.2936
Min–max range of strain means7.0   –   69.34   n 16.4   –   36.399   n
Mean sample size per strain8.1   mice 9.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 541.4942 541.4942 0.8133 0.369
strain 5 10938.9916 2187.7983 3.286 0.0082
sex:strain 5 8306.8626 1661.3725 2.4953 0.0347
Residuals 118 78563.99 665.7965


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 26.286 14.637   7 5.5322 0.5568 16.5, 58.0 -0.21
A/J m 30.929 24.308   7 9.1875 0.7859 10.0, 82.0 0.78
C57BL/6J f 34.955 24.378   11 7.3502 0.6974 18.0, 85.5 0.28
C57BL/6J m 24.273 6.2023   11 1.8701 0.2555 16.0, 37.5 -0.12
CAST/EiJ f 30.0 0.0   1   0.0 0.0 30.0, 30.0 0.0
CAST/EiJ m 17.75 1.0607   2   0.75 0.0598 17.0, 18.5 -1.01
J:DO f 22.44 10.794   15 2.787 0.481 4.6, 44.8 -0.42
J:DO m 36.399 40.496   24 8.2662 1.1126 5.5, 181.0 1.52
NOD/ShiLtJ f 22.71 7.5282   10 2.3806 0.3315 7.4, 37.5 -0.41
NOD/ShiLtJ m 19.171 9.7931   7 3.7015 0.5108 3.2, 34.5 -0.81
NZO/HlLtJ f 27.445 16.819   11 5.0712 0.6128 15.0, 69.5 -0.14
NZO/HlLtJ m 16.4 4.1015   10 1.297 0.2501 11.5, 24.5 -1.19
PWK/PhJ f 69.34 53.35   9 17.784 0.7694 25.5, 185.0 2.2
PWK/PhJ m 32.5 13.194   8 4.6646 0.406 18.5, 58.5 0.99
WSB/EiJ f 7.0 0.0   1   0.0 0.0 7.0, 7.0 -1.29
WSB/EiJ m 24.1 18.49   6 7.5485 0.7672 11.5, 58.0 -0.15


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 26.2857142857 9.7526298665 45.5985765678 6.9728520037
A/J m 30.9285714286 9.7526298665 50.2414337106 11.6157091465
C57BL/6J f 34.9545454545 7.7799072511 50.3608798858 19.5482110233
C57BL/6J m 24.2727272727 7.7799072511 39.679061704 8.8663928415
J:DO f 22.44 6.6623145387 35.6331965969 9.2468034031
J:DO m 36.398625 5.2670221077 46.8287627162 25.9684872838
NOD/ShiLtJ f 22.71 8.1596355629 38.8682998693 6.5517001307
NOD/ShiLtJ m 19.1714285714 9.7526298665 38.4842908535 -0.1414337106
NZO/HlLtJ f 27.4454545455 7.7799072511 42.8517889767 12.0391201142
NZO/HlLtJ m 16.4 8.1596355629 32.5582998693 0.2417001307
PWK/PhJ f 69.3444444444 8.6010110852 86.3767880122 52.3121008767
PWK/PhJ m 32.5 9.1227498951 50.5655284543 14.4344715457


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 28.6071428571 6.896150713 42.2633987409 14.9508869734
C57BL/6J both 29.6136363636 5.5012251742 40.5075599132 18.7197128141
J:DO both 29.4193125 4.2464089798 37.8283583618 21.0102666382
NOD/ShiLtJ both 20.9407142857 6.3579368083 33.5311601098 8.3502684617
NZO/HlLtJ both 21.9227272727 5.6370783513 33.0856770988 10.7597774467
PWK/PhJ both 50.9222222222 6.2690102356 63.3365692222 38.5078752222




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA