Project measure / variable:   CSNA03   infusions_in_0p032

ID, description, units MPD:110196   infusions_in_0p032   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders   [n]  0.032 mg/kg  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders 0.032 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means67.63   n 76.35   n
Median of the strain means59.85   n 60.33   n
SD of the strain means± 26.066 ± 28.091
Coefficient of variation (CV)0.3854 0.3679
Min–max range of strain means39.933   –   107.0   n 51.75   –   121.5   n
Mean sample size per strain8.3   mice 8.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 3668.3602 3668.3602 2.7907 0.098
strain 5 21921.7468 4384.3494 3.3353 0.008
sex:strain 5 35767.7409 7153.5482 5.442 0.0002
Residuals 98 128822.4846 1314.5151


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 43.322 15.428   9 5.1427 0.3561 11.5, 62.0 -0.93
A/J m 121.5 55.51   7 20.982 0.4569 27.6, 189.5 1.61
C57BL/6J f 88.21 35.479   13 9.8401 0.4022 34.5, 149.0 0.79
C57BL/6J m 55.26 27.251   13 7.558 0.4931 9.0, 97.5 -0.75
CAST/EiJ f 107.0 0.0   1   0.0 0.0 107.0, 107.0 1.51
CAST/EiJ m 60.33 31.758   3 18.336 0.5264 41.5, 97.0 -0.57
NOD/ShiLtJ f 49.045 36.738   11 11.077 0.7491 8.5, 131.5 -0.71
NOD/ShiLtJ m 89.71 45.023   7 17.017 0.5018 6.4, 132.5 0.48
NZO/HlLtJ f 59.85 32.935   11 9.9303 0.5503 17.0, 104.5 -0.3
NZO/HlLtJ m 53.39 23.524   10 7.4388 0.4406 12.6, 86.0 -0.82
PWK/PhJ f 86.05 42.224   10 13.352 0.4907 28.0, 159.5 0.71
PWK/PhJ m 102.5 35.635   10 11.269 0.3475 43.6, 161.5 0.93
WSB/EiJ f 39.933 28.308   3 16.344 0.7089 16.8, 71.5 -1.06
WSB/EiJ m 51.75 52.63   6 21.485 1.017 19.0, 151.5 -0.88


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 43.3222222222 12.0854142984 67.3053335716 19.3391108729
A/J m 121.5 13.7035717391 148.6942921268 94.3057078732
C57BL/6J f 88.2076923077 10.0556725242 108.1628471651 68.2525374503
C57BL/6J m 55.2615384615 10.0556725242 75.2166933189 35.3063836042
NOD/ShiLtJ f 49.0454545455 10.9316685446 70.7389949958 27.3519140951
NOD/ShiLtJ m 89.7142857143 13.7035717391 116.9085778411 62.5199935874
NZO/HlLtJ f 59.8545454545 10.9316685446 81.5480859049 38.1610050042
NZO/HlLtJ m 53.39 11.4652306949 76.1423771724 30.6376228276
PWK/PhJ f 86.05 11.4652306949 108.8023771724 63.2976228276
PWK/PhJ m 102.535 11.4652306949 125.2873771724 79.7826228276
WSB/EiJ f 39.9333333333 20.9325515953 81.473300714 -1.6066340473
WSB/EiJ m 51.75 14.8015491806 81.1231926251 22.3768073749


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 82.4111111111 9.1357144928 100.5406391957 64.2815830265
C57BL/6J both 71.7346153846 7.1104342312 85.8450407039 57.6241900653
NOD/ShiLtJ both 69.3798701299 8.7648339342 86.7733978166 51.9863424432
NZO/HlLtJ both 56.6222727273 7.9207463672 72.3407361085 40.9038093461
PWK/PhJ both 94.2925 8.1071423722 110.3808601867 78.2041398133
WSB/EiJ both 45.8416666667 12.8185176057 71.2795976703 20.403735663




  GWAS USING LINEAR MIXED MODELS