Project measure / variable:   CSNA03   infusions_in_0p056

ID, description, units MPD:110195   infusions_in_0p056   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders   [n]  0.056 mg/kg  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders 0.056 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means68.69   n 78.92   n
Median of the strain means71.01   n 77.76   n
SD of the strain means± 33.607 ± 26.066
Coefficient of variation (CV)0.4893 0.3303
Min–max range of strain means11.4   –   105.2   n 52.5   –   130.4   n
Mean sample size per strain7.7   mice 8.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2148.2728 2148.2728 1.6241 0.2058
strain 5 40503.2126 8100.6425 6.1243 < 0.0001
sex:strain 5 16383.7171 3276.7434 2.4773 0.0376
Residuals 91 120366.7417 1322.7114


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 39.322 26.197   9 8.7324 0.6662 -0.87
A/J m 77.76 52.94   7 20.011 0.6809 16.0, 180.0 -0.04
C57BL/6J f 105.2 42.751   11 12.89 0.4065 53.0, 181.5 1.09
C57BL/6J m 79.69 35.092   11 10.581 0.4404 35.5, 139.5 0.03
CAST/EiJ f 92.0 41.012   2   29.0 0.4458 63.0, 121.0 0.69
CAST/EiJ m 63.0 23.754   3 13.714 0.377 39.5, 87.0 -0.61
NOD/ShiLtJ f 71.01 34.468   10 10.9 0.4854 22.0, 134.0 0.07
NOD/ShiLtJ m 89.3 45.193   8 15.978 0.5061 5.2, 134.0 0.4
NZO/HlLtJ f 65.94 31.478   12 9.0871 0.4774 10.0, 112.5 -0.08
NZO/HlLtJ m 59.81 31.48   11 9.4917 0.5263 -0.73
PWK/PhJ f 95.94 39.453   9 13.151 0.4112 44.5, 165.5 0.81
PWK/PhJ m 130.4 26.677   10 8.4359 0.2045 91.0, 183.0 1.97
WSB/EiJ f 11.4 0.0   1   0.0 0.0 11.4, 11.4 -1.7
WSB/EiJ m 52.5 42.137   6 17.202 0.8026 19.0, 130.0 -1.01


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 39.3222222222 12.1230333915 63.4031387934 15.241305651
A/J m 77.7571428571 13.7462277813 105.0623356814 50.4519500329
C57BL/6J f 105.1636363636 10.9656962947 126.9456449658 83.3816277615
C57BL/6J m 79.6909090909 10.9656962947 101.4729176931 57.9089004887
CAST/EiJ f 92.0 25.7168373591 143.0833382141 40.9166617859
CAST/EiJ m 63.0 20.997709776 104.7093709942 21.2906290058
NOD/ShiLtJ f 71.01 11.5009193003 93.8551633529 48.1648366471
NOD/ShiLtJ m 89.3 12.8584186796 114.841669107 63.758330893
NZO/HlLtJ f 65.9416666667 10.498854888 86.7963521638 45.0869811696
NZO/HlLtJ m 59.8090909091 10.9656962947 81.5910995113 38.0270823069
PWK/PhJ f 95.9444444444 12.1230333915 120.0253610157 71.8635278732
PWK/PhJ m 130.45 11.5009193003 153.2951633529 107.6048366471


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 58.5396825397 9.1641518542 76.7431444225 40.3362206568
C57BL/6J both 92.4272727273 7.7539182104 107.8294787177 77.0250667368
CAST/EiJ both 77.5 16.6001471348 110.4741530286 44.5258469714
NOD/ShiLtJ both 80.155 8.6256894752 97.2888725146 63.0211274854
NZO/HlLtJ both 62.8753787879 7.5906595429 77.953291491 47.7974660848
PWK/PhJ both 113.1972222222 8.3552241646 129.7938486229 96.6005958216




  GWAS USING LINEAR MIXED MODELS