Project measure / variable:   CSNA03   infusions_in_0p1

ID, description, units MPD:110193   infusions_in_0p1   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders   [n]  0.1 mg/kg  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders 0.1 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means87.41   n 89.4   n
Median of the strain means93.98   n 82.26   n
SD of the strain means± 30.849 ± 30.603
Coefficient of variation (CV)0.3529 0.3423
Min–max range of strain means43.433   –   124.2   n 46.65   –   136.2   n
Mean sample size per strain9.3   mice 8.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 315.8767 315.8767 0.1391 0.7099
strain 6 45786.9623 7631.1604 3.3596 0.0044
sex:strain 6 32233.0337 5372.1723 2.3651 0.0346
Residuals 110 249860.2669 2271.457


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 60.43 50.93   11 15.357 0.8429 0.4, 164.0 -0.87
A/J m 136.2 89.62   7 33.874 0.658 10.5, 242.0 1.53
C57BL/6J f 100.8 41.036   13 11.381 0.4072 49.0, 175.0 0.43
C57BL/6J m 82.73 25.843   13 7.1675 0.3124 37.0, 119.0 -0.22
CAST/EiJ f 124.2 63.35   3 36.575 0.5102 65.0, 191.0 1.19
CAST/EiJ m 77.5 32.047   3 18.502 0.4135 40.5, 96.5 -0.39
NOD/ShiLtJ f 68.33 52.78   13 14.639 0.7725 8.8, 169.0 -0.62
NOD/ShiLtJ m 82.26 56.42   9 18.806 0.6859 -0.23
NZO/HlLtJ f 93.98 52.26   12 15.086 0.5561 27.8, 201.5 0.21
NZO/HlLtJ m 76.47 41.063   11 12.381 0.537 0.6, 117.0 -0.42
PWK/PhJ f 120.7 27.683   10 8.7541 0.2293 70.0, 154.0 1.08
PWK/PhJ m 124.0 37.996   10 12.015 0.3063 67.5, 200.0 1.13
WSB/EiJ f 43.433 46.048   3 26.586 1.0602 14.0, 96.5 -1.43
WSB/EiJ m 46.65 38.711   6 15.804 0.8298 20.5, 124.5 -1.4


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 60.4272727273 14.3699717585 88.9051838635 31.9493615911
A/J m 136.2142857143 18.0137129184 171.9132365782 100.5153348503
C57BL/6J f 100.7769230769 13.2184514738 126.9727912912 74.5810548626
C57BL/6J m 82.7307692308 13.2184514738 108.9266374451 56.5349010165
CAST/EiJ f 124.1666666667 27.5164009986 178.6977148549 69.6356184785
CAST/EiJ m 77.5 27.5164009986 132.0310481882 22.9689518118
NOD/ShiLtJ f 68.3307692308 13.2184514738 94.5266374451 42.1349010165
NOD/ShiLtJ m 82.2555555556 15.8866015237 113.7390709062 50.7720402049
NZO/HlLtJ f 93.9833333333 13.7582004993 121.2488574274 66.7178092392
NZO/HlLtJ m 76.4727272727 14.3699717585 104.9506384089 47.9948161365
PWK/PhJ f 120.74 15.0713535283 150.6078851771 90.8721148229
PWK/PhJ m 124.05 15.0713535283 153.9178851771 94.1821148229
WSB/EiJ f 43.4333333333 27.5164009986 97.9643815215 -11.0977148549
WSB/EiJ m 46.65 19.4570337399 85.2092739591 8.0907260409


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 98.3207792208 11.5216094953 121.1539049128 75.4876535288
C57BL/6J both 91.7538461538 9.3468566739 110.2771222072 73.2305701005
CAST/EiJ both 100.8333333333 19.4570337399 139.3926072924 62.2740593743
NOD/ShiLtJ both 75.2931623932 10.3333388522 95.7714145789 54.8149102074
NZO/HlLtJ both 85.228030303 9.9471625266 104.9409716539 65.5150889522
PWK/PhJ both 122.395 10.6570562815 143.5147841484 101.2752158516
WSB/EiJ both 45.0416666667 16.8502855011 78.4349774667 11.6483558666




  GWAS USING LINEAR MIXED MODELS