Project measure / variable:   CSNA03   infusions_in_0p56

ID, description, units MPD:110191   infusions_in_0p56   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders   [n]  0.56 mg/kg  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders 0.56 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means55.08   n 49.676   n
Median of the strain means59.14   n 49.711   n
SD of the strain means± 24.218 ± 16.677
Coefficient of variation (CV)0.4397 0.3357
Min–max range of strain means12.75   –   88.5   n 22.929   –   75.77   n
Mean sample size per strain9.0   mice 8.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1048.3955 1048.3955 1.4295 0.2344
strain 6 23991.9549 3998.6592 5.4524 < 0.0001
sex:strain 6 6986.9993 1164.4999 1.5879 0.1573
Residuals 110 80671.7173 733.3792


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 59.86 42.502   9 14.167 0.7101 7.0, 122.0 0.2
A/J m 63.15 40.729   8 14.4 0.645 20.5, 148.5 0.81
C57BL/6J f 59.14 20.601   11 6.2115 0.3484 35.0, 104.5 0.17
C57BL/6J m 44.582 10.341   11 3.118 0.232 32.5, 68.0 -0.31
CAST/EiJ f 88.5 49.312   6 20.132 0.5572 36.5, 177.0 1.38
CAST/EiJ m 41.625 15.413   4 7.7065 0.3703 21.0, 58.0 -0.48
NOD/ShiLtJ f 52.33 23.075   12 6.6613 0.4409 20.5, 92.0 -0.11
NOD/ShiLtJ m 49.711 31.501   9 10.5 0.6337 11.4, 110.5 0.0
NZO/HlLtJ f 39.769 7.693   13 2.1337 0.1934 28.0, 59.0 -0.63
NZO/HlLtJ m 49.964 20.08   11 6.0544 0.4019 30.5, 98.4 0.02
PWK/PhJ f 73.22 23.509   10 7.434 0.3211 33.5, 112.5 0.75
PWK/PhJ m 75.77 35.445   11 10.687 0.4678 46.5, 161.0 1.56
WSB/EiJ f 12.75 3.8891   2   2.75 0.305 10.0, 15.5 -1.75
WSB/EiJ m 22.929 7.4466   7 2.8146 0.3248 10.0, 33.5 -1.6


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 59.8555555556 9.026991923 77.7449347507 41.9661763604
A/J m 63.15 9.5745708037 82.1245520102 44.1754479898
C57BL/6J f 59.1363636364 8.1652214166 75.3179159607 42.954811312
C57BL/6J m 44.5818181818 8.1652214166 60.7633705062 28.4002658574
CAST/EiJ f 88.5 11.0557620618 110.4099254216 66.5900745784
CAST/EiJ m 41.625 13.5404878845 68.4590687927 14.7909312073
NOD/ShiLtJ f 52.3333333333 7.8176043251 67.8259901743 36.8406764924
NOD/ShiLtJ m 49.7111111111 9.026991923 67.6004903063 31.821731916
NZO/HlLtJ f 39.7692307692 7.5109112865 54.6540939941 24.8843675444
NZO/HlLtJ m 49.9636363636 8.1652214166 66.145188688 33.7820840393
PWK/PhJ f 73.22 8.563756469 90.1913552549 56.2486447451
PWK/PhJ m 75.7727272727 8.1652214166 91.9542795971 59.5911749483
WSB/EiJ f 12.75 19.1491416075 50.6991040203 -25.1991040203
WSB/EiJ m 22.9285714286 10.2356467351 43.2132207684 2.6439220887


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 61.5027777778 6.5794944573 74.5417914672 48.4637640883
C57BL/6J both 51.8590909091 5.7736834336 63.3011762878 40.4170055304
CAST/EiJ both 65.0625 8.7403473461 82.3838169242 47.7411830758
NOD/ShiLtJ both 51.0222222222 5.9707939288 62.8549343372 39.1895101073
NZO/HlLtJ both 44.8664335664 5.5471756132 55.8596336107 33.8732335222
PWK/PhJ both 74.4963636364 5.9162649882 86.2210121899 62.7717150828
WSB/EiJ both 17.8392857143 10.8565428244 39.3544053676 -3.675833939




  GWAS USING LINEAR MIXED MODELS