Project measure / variable:   CSNA03   infusions_in_1p8

ID, description, units MPD:110190   infusions_in_1p8   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders   [n]  1.8 mg/kg  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders 1.8 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means31.105   n 23.589   n
Median of the strain means27.445   n 24.1   n
SD of the strain means± 19.0 ± 6.3154
Coefficient of variation (CV)0.6108 0.2677
Min–max range of strain means7.0   –   69.34   n 16.4   –   32.5   n
Mean sample size per strain7.1   mice 7.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 3073.6559 3073.6559 6.3488 0.0137
strain 4 11010.3022 2752.5755 5.6856 0.0004
sex:strain 4 3892.8016 973.2004 2.0102 0.1008
Residuals 81 39214.5647 484.1304


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 26.286 14.637   7 5.5322 0.5568 16.5, 58.0 -0.25
A/J m 30.929 24.308   7 9.1875 0.7859 10.0, 82.0 1.16
C57BL/6J f 34.955 24.378   11 7.3502 0.6974 18.0, 85.5 0.2
C57BL/6J m 24.273 6.2023   11 1.8701 0.2555 16.0, 37.5 0.11
CAST/EiJ f 30.0 0.0   1   0.0 0.0 30.0, 30.0 -0.06
CAST/EiJ m 17.75 1.0607   2   0.75 0.0598 17.0, 18.5 -0.92
NOD/ShiLtJ f 22.71 7.5282   10 2.3806 0.3315 7.4, 37.5 -0.44
NOD/ShiLtJ m 19.171 9.7931   7 3.7015 0.5108 3.2, 34.5 -0.7
NZO/HlLtJ f 27.445 16.819   11 5.0712 0.6128 15.0, 69.5 -0.19
NZO/HlLtJ m 16.4 4.1015   10 1.297 0.2501 11.5, 24.5 -1.14
PWK/PhJ f 69.34 53.35   9 17.784 0.7694 25.5, 185.0 2.01
PWK/PhJ m 32.5 13.194   8 4.6646 0.406 18.5, 58.5 1.41
WSB/EiJ f 7.0 0.0   1   0.0 0.0 7.0, 7.0 -1.27
WSB/EiJ m 24.1 18.49   6 7.5485 0.7672 11.5, 58.0 0.08


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 26.2857142857 8.3163387269 42.832619712 9.7388088595
A/J m 30.9285714286 8.3163387269 47.4754768548 14.3816660023
C57BL/6J f 34.9545454545 6.6341432875 48.1544096215 21.7546812876
C57BL/6J m 24.2727272727 6.6341432875 37.4725914397 11.0728631057
NOD/ShiLtJ f 22.71 6.95794818 36.554134333 8.865865667
NOD/ShiLtJ m 19.1714285714 8.3163387269 35.7183339977 2.6245231452
NZO/HlLtJ f 27.4454545455 6.6341432875 40.6453187124 14.2455903785
NZO/HlLtJ m 16.4 6.95794818 30.244134333 2.555865667
PWK/PhJ f 69.3444444444 7.3343213634 83.937443353 54.7514455359
PWK/PhJ m 32.5 7.7792225572 47.9782127291 17.0217872709


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 28.6071428571 5.8805395085 40.3075718917 16.9067138226
C57BL/6J both 29.6136363636 4.691047706 38.9473498269 20.2799229004
NOD/ShiLtJ both 20.9407142857 5.4215895431 31.7279768511 10.1534517204
NZO/HlLtJ both 21.9227272727 4.8068934884 31.4869375048 12.3585170406
PWK/PhJ both 50.9222222222 5.3457593814 61.5586065519 40.2858378926




  GWAS USING LINEAR MIXED MODELS