Project measure / variable:   CSNA03   infusions_in_1p0

ID, description, units MPD:110189   infusions_in_1p0   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders   [n]  1.0 mg/kg  
cocaine study
Data set, strains CSNA03   inbred w/CC8   8 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders 1.0 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means22.685   n 25.322   n
Median of the strain means23.047   n 27.346   n
SD of the strain means± 15.795 ± 16.248
Coefficient of variation (CV)0.6963 0.6417
Min–max range of strain means0.0   –   50.83   n 0.0   –   46.646   n
Mean sample size per strain15.8   mice 13.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 13.6456 13.6456 0.0449 0.8323
strain 7 48601.9516 6943.1359 22.8653 < 0.0001
sex:strain 7 1445.3125 206.4732 0.68 0.6889
Residuals 214 64981.8319 303.6534


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.0 0.0   12 0.0 None -1.44
129S1/SvImJ m 0.0 0.0   12 0.0 None -1.56
A/J f 26.673 24.08   15 6.2175 0.9028 0.25
A/J m 30.416 20.301   11 6.1208 0.6674 0.31
C57BL/6J f 18.49 16.371   24 3.3417 0.8854 -0.27
C57BL/6J m 16.898 13.939   21 3.0416 0.8249 -0.52
CAST/EiJ f 33.474 30.643   10 9.6901 0.9154 4.0, 102.5 0.68
CAST/EiJ m 46.646 25.16   8 8.8954 0.5394 17.5, 96.0 1.31
NOD/ShiLtJ f 25.1 13.891   15 3.5867 0.5534 0.15
NOD/ShiLtJ m 26.192 13.963   10 4.4154 0.5331 1.9167, 49.5 0.05
NZO/HlLtJ f 20.995 6.6902   14 1.788 0.3187 4.4286, 34.0 -0.11
NZO/HlLtJ m 28.5 10.927   11 3.2946 0.3834 20.0, 59.0 0.2
PWK/PhJ f 50.83 30.668   18 7.2286 0.6033 12.0, 115.5 1.78
PWK/PhJ m 44.836 21.913   14 5.8564 0.4887 25.5, 100.0 1.2
WSB/EiJ f 5.9188 3.9541   18 0.93198 0.6681 -1.06
WSB/EiJ m 9.0892 8.2222   17 1.9942 0.9046 -1.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.0 5.0303530355 9.9153854982 -9.9153854982
129S1/SvImJ m 0.0 5.0303530355 9.9153854982 -9.9153854982
A/J f 26.6732333333 4.4992845352 35.5418237322 17.8046429345
A/J m 30.4160909091 5.2540323903 40.7723733016 20.0598085165
C57BL/6J f 18.4898320833 3.5569967431 25.5010684072 11.4785957595
C57BL/6J m 16.898047619 3.8025894682 24.3933745281 9.40272071
CAST/EiJ f 33.47381 5.5104756595 44.3355706074 22.6120493926
CAST/EiJ m 46.645875 6.1608990815 58.7896925368 34.5020574632
NOD/ShiLtJ f 25.1 4.4992845352 33.9685903988 16.2314096012
NOD/ShiLtJ m 26.19167 5.5104756595 37.0534306074 15.3299093926
NZO/HlLtJ f 20.9949 4.6572019492 30.1747631912 11.8150368088
NZO/HlLtJ m 28.5 5.2540323903 38.8562823925 18.1437176075
PWK/PhJ f 50.8325 4.1072660543 58.9283783579 42.7366216421
PWK/PhJ m 44.8357142857 4.6572019492 54.0155774769 35.6558510945
WSB/EiJ f 5.9188 4.1072660543 14.0146783579 -2.1770783579
WSB/EiJ m 9.0891588235 4.2263419027 17.4197489267 0.7585687204


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.0 3.5569967431 7.0112363239 -7.0112363239
A/J both 28.5446621212 3.4586275344 35.3620017903 21.7273224521
C57BL/6J both 17.6939398512 2.6034550358 22.8256393811 12.5622403213
CAST/EiJ both 40.0598425 4.1328567446 48.2061629556 31.9135220444
NOD/ShiLtJ both 25.645835 3.5569967431 32.6570713239 18.6345986761
NZO/HlLtJ both 24.74745 3.5104980542 31.6670322346 17.8278677654
PWK/PhJ both 47.8341071429 3.1048012995 53.954015937 41.7141983487
WSB/EiJ both 7.5039794118 2.9466761071 13.3122058591 1.6957529645




  GWAS USING LINEAR MIXED MODELS