ITP survival analysis:   syringaresinol

Intervention:   syringaresinol     component of ginseng berry
Trial code: Syr Dose: 300 ppm initiated at age: 5 mo Sex: both Cohort: C2017
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Syr effect on survival, females, test site = All
Log-rank test chisq = 0.0 p = 0.9982
Wang-Allison test odds ratio = 0.7653 p = 0.4977
Quantiles Syr Control % difference
25% died before day: 763 767 -1 %
Median lifespan (days) 853 868 -2 %
75% died before day: 958 958 0 %
90% died before day: 1051 1060 -1 %
Max lifespan observed (days) 1229 1221
Number of mice at start 136 276
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Syr effect on survival, males, test site = All
Log-rank test chisq = 0.0054 p = 0.9413
Wang-Allison test odds ratio = 0.7399 p = 0.4137
Quantiles Syr Control % difference
25% died before day: 536 447 +20 %
Median lifespan (days) 763 718 +6 %
75% died before day: 926 919 +1 %
90% died before day: 1011 1029 -2 %
Max lifespan observed (days) 1177 1258
Number of mice at start 152 285
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Syr effect on survival, females, test site = TJL
Log-rank test chisq = 1.142 p = 0.2852
Wang-Allison test odds ratio = 1.3778 p = 0.5725
Quantiles Syr Control % difference
25% died before day: 770 760 +1 %
Median lifespan (days) 896 870 +3 %
75% died before day: 1020 968 +5 %
90% died before day: 1085 1068 +2 %
Max lifespan observed (days) 1229 1209
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Syr effect on survival, males, test site = TJL
Log-rank test chisq = 1.8248 p = 0.1767
Wang-Allison test odds ratio = 0.2483 p = 0.0916
Quantiles Syr Control % difference
25% died before day: 512 488 +5 %
Median lifespan (days) 769 748 +3 %
75% died before day: 915 949 -4 %
90% died before day: 1018 1079 -6 %
Max lifespan observed (days) 1070 1226
Number of mice at start 53 102
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Syr effect on survival, females, test site = UM
Log-rank test chisq = 5.095 p = 0.024
Wang-Allison test odds ratio = 0.1392 p = 0.0351
Quantiles Syr Control % difference
25% died before day: 758 820 -8 %
Median lifespan (days) 831 902 -8 %
75% died before day: 941 1000 -6 %
90% died before day: 1046 1098 -5 %
Max lifespan observed (days) 1171 1221
Number of mice at start 44 90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Syr effect on survival, males, test site = UM
Log-rank test chisq = 0.7436 p = 0.3885
Wang-Allison test odds ratio = 0.7108 p = 0.7698
Quantiles Syr Control % difference
25% died before day: 544 468 +16 %
Median lifespan (days) 742 790 -6 %
75% died before day: 884 933 -5 %
90% died before day: 1007 1019 -1 %
Max lifespan observed (days) 1138 1233
Number of mice at start 48 88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Syr effect on survival, females, test site = UT
Log-rank test chisq = 0.841 p = 0.3591
Wang-Allison test odds ratio = 1.1526 p = 0.7728
Quantiles Syr Control % difference
25% died before day: 771 696 +11 %
Median lifespan (days) 854 824 +4 %
75% died before day: 938 937 0 %
90% died before day: 1087 993 +9 %
Max lifespan observed (days) 1182 1198
Number of mice at start 44 90
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Syr effect on survival, males, test site = UT
Log-rank test chisq = 4.685 p = 0.0304
Wang-Allison test odds ratio = 1.7233 p = 0.3927
Quantiles Syr Control % difference
25% died before day: 642 400 +60 %
Median lifespan (days) 805 676 +19 %
75% died before day: 948 825 +15 %
90% died before day: 1000 963 +4 %
Max lifespan observed (days) 1177 1258
Number of mice at start 51 95
Animal censor events are denoted by + marks in the plot


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Statistical definitions