ITP survival analysis: syringaresinol
Intervention:
syringaresinol
component of ginseng berry
Trial code: Syr
Dose: 300 ppm
initiated at age: 5 mo
Sex: both
Cohort: C2017
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Syr effect on survival,
females, test site = All
Log-rank test
chisq = 0.0
p = 0.9982
Wang-Allison test
odds ratio = 0.7653
p = 0.4977
Quantiles
Syr
Control
% difference
25% died before day:
763
767
-1 %
Median lifespan (days)
853
868
-2 %
75% died before day:
958
958
0 %
90% died before day:
1051
1060
-1 %
Max lifespan observed (days)
1229
1221
Number of mice at start
136
276
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Syr effect on survival,
males, test site = All
Log-rank test
chisq = 0.0054
p = 0.9413
Wang-Allison test
odds ratio = 0.7399
p = 0.4137
Quantiles
Syr
Control
% difference
25% died before day:
536
447
+20 %
Median lifespan (days)
763
718
+6 %
75% died before day:
926
919
+1 %
90% died before day:
1011
1029
-2 %
Max lifespan observed (days)
1177
1258
Number of mice at start
152
285
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Syr effect on survival,
females, test site = TJL
Log-rank test
chisq = 1.142
p = 0.2852
Wang-Allison test
odds ratio = 1.3778
p = 0.5725
Quantiles
Syr
Control
% difference
25% died before day:
770
760
+1 %
Median lifespan (days)
896
870
+3 %
75% died before day:
1020
968
+5 %
90% died before day:
1085
1068
+2 %
Max lifespan observed (days)
1229
1209
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Syr effect on survival,
males, test site = TJL
Log-rank test
chisq = 1.8248
p = 0.1767
Wang-Allison test
odds ratio = 0.2483
p = 0.0916
Quantiles
Syr
Control
% difference
25% died before day:
512
488
+5 %
Median lifespan (days)
769
748
+3 %
75% died before day:
915
949
-4 %
90% died before day:
1018
1079
-6 %
Max lifespan observed (days)
1070
1226
Number of mice at start
53
102
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Syr effect on survival,
females, test site = UM
Log-rank test
chisq = 5.095
p = 0.024
Wang-Allison test
odds ratio = 0.1392
p = 0.0351
Quantiles
Syr
Control
% difference
25% died before day:
758
820
-8 %
Median lifespan (days)
831
902
-8 %
75% died before day:
941
1000
-6 %
90% died before day:
1046
1098
-5 %
Max lifespan observed (days)
1171
1221
Number of mice at start
44
90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Syr effect on survival,
males, test site = UM
Log-rank test
chisq = 0.7436
p = 0.3885
Wang-Allison test
odds ratio = 0.7108
p = 0.7698
Quantiles
Syr
Control
% difference
25% died before day:
544
468
+16 %
Median lifespan (days)
742
790
-6 %
75% died before day:
884
933
-5 %
90% died before day:
1007
1019
-1 %
Max lifespan observed (days)
1138
1233
Number of mice at start
48
88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Syr effect on survival,
females, test site = UT
Log-rank test
chisq = 0.841
p = 0.3591
Wang-Allison test
odds ratio = 1.1526
p = 0.7728
Quantiles
Syr
Control
% difference
25% died before day:
771
696
+11 %
Median lifespan (days)
854
824
+4 %
75% died before day:
938
937
0 %
90% died before day:
1087
993
+9 %
Max lifespan observed (days)
1182
1198
Number of mice at start
44
90
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Syr effect on survival,
males, test site = UT
Log-rank test
chisq = 4.685
p = 0.0304
Wang-Allison test
odds ratio = 1.7233
p = 0.3927
Quantiles
Syr
Control
% difference
25% died before day:
642
400
+60 %
Median lifespan (days)
805
676
+19 %
75% died before day:
948
825
+15 %
90% died before day:
1000
963
+4 %
Max lifespan observed (days)
1177
1258
Number of mice at start
51
95
Animal censor events are denoted by + marks in the plot
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National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions