ITP survival analysis: L-leucine
Intervention:
L-leucine
Trial code: Leu
Dose: 40,000 ppm
initiated at age: 5 mo
Sex: both
Cohort: C2017
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Leu effect on survival,
females, test site = All
Log-rank test
chisq = 1.635
p = 0.201
Wang-Allison test
odds ratio = 1.3842
p = 0.3908
Quantiles
Leu
Control
% difference
25% died before day:
777
767
+1 %
Median lifespan (days)
853
868
-2 %
75% died before day:
968
958
+1 %
90% died before day:
1109
1060
+5 %
Max lifespan observed (days)
1285
1221
Number of mice at start
135
276
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Leu effect on survival,
males, test site = All
Log-rank test
chisq = 1.2051
p = 0.2723
Wang-Allison test
odds ratio = 0.7675
p = 0.5083
Quantiles
Leu
Control
% difference
25% died before day:
477
447
+7 %
Median lifespan (days)
720
718
0 %
75% died before day:
865
919
-6 %
90% died before day:
1020
1029
-1 %
Max lifespan observed (days)
1180
1258
Number of mice at start
147
285
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Leu effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.1793
p = 0.6719
Wang-Allison test
odds ratio = 1.0
p = 1.0
Quantiles
Leu
Control
% difference
25% died before day:
763
760
0 %
Median lifespan (days)
882
870
+1 %
75% died before day:
1013
968
+5 %
90% died before day:
1109
1068
+4 %
Max lifespan observed (days)
1177
1209
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Leu effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.6326
p = 0.4264
Wang-Allison test
odds ratio = 0.43
p = 0.2656
Quantiles
Leu
Control
% difference
25% died before day:
370
488
-24 %
Median lifespan (days)
718
748
-4 %
75% died before day:
972
949
+2 %
90% died before day:
1034
1079
-4 %
Max lifespan observed (days)
1139
1226
Number of mice at start
51
102
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Leu effect on survival,
females, test site = UM
Log-rank test
chisq = 0.4863
p = 0.4856
Wang-Allison test
odds ratio = 0.8217
p = 1.0
Quantiles
Leu
Control
% difference
25% died before day:
766
820
-7 %
Median lifespan (days)
841
902
-7 %
75% died before day:
919
1000
-8 %
90% died before day:
1086
1098
-1 %
Max lifespan observed (days)
1285
1221
Number of mice at start
43
90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Leu effect on survival,
males, test site = UM
Log-rank test
chisq = 2.5839
p = 0.108
Wang-Allison test
odds ratio = 0.7625
p = 0.7719
Quantiles
Leu
Control
% difference
25% died before day:
505
468
+8 %
Median lifespan (days)
720
790
-9 %
75% died before day:
792
933
-15 %
90% died before day:
980
1019
-4 %
Max lifespan observed (days)
1180
1233
Number of mice at start
45
88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Leu effect on survival,
females, test site = UT
Log-rank test
chisq = 5.646
p = 0.0175
Wang-Allison test
odds ratio = 3.0816
p = 0.0674
Quantiles
Leu
Control
% difference
25% died before day:
791
696
+14 %
Median lifespan (days)
863
824
+5 %
75% died before day:
964
937
+3 %
90% died before day:
1112
993
+12 %
Max lifespan observed (days)
1280
1198
Number of mice at start
44
90
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Leu effect on survival,
males, test site = UT
Log-rank test
chisq = 0.1424
p = 0.7059
Wang-Allison test
odds ratio = 1.2719
p = 0.7762
Quantiles
Leu
Control
% difference
25% died before day:
509
400
+27 %
Median lifespan (days)
723
676
+7 %
75% died before day:
859
825
+4 %
90% died before day:
979
963
+2 %
Max lifespan observed (days)
1171
1258
Number of mice at start
51
95
Animal censor events are denoted by + marks in the plot
See our
ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions