Vanderlinden1: Drinking in the dark alcohol consumption in 43 ILSXISS recombinant inbred strains of mice (2015)

Vanderlinden LA, Saba LM, Bennett B, Hoffman PL, Tabakoff . Influence of sex on genetic regulation of 'drinking in the dark' alcohol consumption. Mamm Genome. 2015 Feb;26(1-2):43-56. doi: 10.1007/s00335-014-9553-8. Epub 2015 Jan 6.   PubMed 25559016     FullText


         
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Participants Lauren A Vanderlinden       University of Colorado,  Aurora, CO
Laura Saba       University of Colorado Denver School of Medicine,  Aurora, CO
Beth Bennett       University of Colorado Denver School of Medicine,  Aurora, CO
Paula A Hoffman       University of Colorado Denver School of Medicine,  Aurora, CO
Boris Tabakoff       University of Colorado Denver School of Medicine,  Aurora, CO
ContactLauren A Vanderlinden     lauren.vanderlinden@ucdenver.edu
AcknowledgementsFunding provided by NIH AA013162, AA16649; Banbury Fund
Project type Phenotype strain survey data set
MPD identifiersVanderlinden1     MPD:543
Data changelog No updates/corrections.       Initial release date: 04/2016.
Formatted citation
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ILSXISS recombinant inbred mice were used to investigate genetic influences of alcohol consumption in the "drinking in the dark" model. Mice were given access to 20% ethanol during the early phase of their circadian dark cycle for four consecutive days. Alcohol-preferring strains of mice consume an amount of alcohol during this time that produces blood ethanol levels that are comparable to the levels that define binge drinking in humans.

Summary of procedures that were conducted
• body weight
• intake monitoring Ethanol consumed during 2h availability during dark phase. 4 days/trials with variations.
Mice: ILSXISS   43 strains   ♀♂   age 8-23wks   1 cohort