Shorter1: Male fertility assessment in 347 pre-CC lines of the Collaborative Cross that are now extinct (2017)

Shorter JR, Odet F, Aylor DL, Pan W, Kao CY, Fu CP, Morgan AP, Greenstein S, Bell TA, Stevans AM, Feathers RW, Patel S, Cates SE, Shaw GD, Miller DR, Chesler EJ, McMillian L, O'Brien DA, Villena FP. Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross. Genetics. 2017 Jun;206(2):557-572. doi: 10.1534/genetics.116.199596.   PubMed 28592496  


     
The extinction rate among pre-CC lines has been estimated at 95%. Male infertility played a large role in extinction as 47% of extinct lines had males that were infertile. Males from extinct lines had high variability in reproductive organ size, low sperm counts, low sperm motility, and a high rate of vacuolization of seminiferous tubules. In this study, the investigators supplied data comparing genetically fertile versus genetically infertile extinct lines. See also Odet1 and Odet2 for male fertility phenotypes in CC founder strains.

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Participants John R Shorter       University of North Carolina Chapel Hill, NC
Deborah A O'Brien       University of North Carolina Chapel Hill, NC
Fernando Pardo-Manuel de Villena       University of North Carolina Chapel Hill, NC
With: Odet F, Aylor DL, Pan W, Kao CY, Fu CP, Morgan AP, Greenstein S, Bell TA, Stevans AM, Feathers RW, Patel S, Cates SE, Shaw GD, Miller DR, Chesler EJ, McMillian L
ContactFernando Pardo-Manuel de Villena     fernando@med.unc.edu
Project type Phenotype archive study
MPD identifiersShorter1     MPD:600
Data changelog No updates/corrections.       Initial release date: 08/2017.
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Protocol       Animal documentation