Rhodes1: Exercise-induced hippocampal neurogenesis in adults of 12 diverse strains of mice (2010)

Clark PJ, Kohman RA, Miller DS, Bhattacharya TK, Brzezinska WJ, Rhodes JS. Genetic influences on exercise-induced adult hippocampal neurogenesis across 12 divergent mouse strains. Genes Brain Behav. 2011 Apr;10(3):345-53. doi: 10.1111/j.1601-183X.2010.00674.x. Epub 2011 Jan 12.   PubMed 21223504  


         

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Participants Justin S Rhodes       University of Illinois at Urbana-Champaign Champaign, IL
Peter J Clark       University of Illinois at Urbana-Champaign Champaign, IL
With: Kohman RA, Miller DS, Bhattacharya TK, Brezinska WJ
ContactJustin S Rhodes     jrhodes@illinois.edu     Lab web site
AcknowledgementsFunding provided by NIH MH083807, DA027487
Project type Phenotype strain survey data set
MPD identifiersRhodes1     MPD:346
Data changelog No updates/corrections.       Initial release date: 01/2011.
Formatted citation
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Mice were divided into 2 cohorts: 1) housed with a running wheel; 2) housed without a wheel. The purpose of this study was to quantitate exercise-induced neurogenesis. For the first 10 days, all mice received daily injections of BrdU to label dividing cells. After 43 days, neurogenesis was assessed immunohistochemically based on the number of BrdU cells co-expressing a neuronal cell marker in the hippocampus dentate gyrus. Daily locomotor activity and its effect on body weight were also recorded.

Summary of procedures that were conducted
• running wheel monitoring Locomotor activity. Exercise wheel group vs. control group. Distance per day.
• body weight Exercise wheel group vs. control group.
• microscopy Examination of hippocampus dentate gyrus. Exercise wheel group vs. control group.
Mice: inbred   12 strains   ♀♂   age 8-15wks   2 cohorts