Hadsell1: Maternal nurturing in 31 inbred strains of mice (2012)

Hadsell DL, Wei J, Olea W, Hadsell LA, Renwick A, Thomson PC, Shariflou M, Williamson P. In silico QTL mapping of maternal nurturing ability with the mouse diversity panel. Physiol Genomics. 2012 Aug 17;44(16):787-98. doi: 10.1152/physiolgenomics.00159.201Epub 2012 Jul 3.   PubMed 22759921     FullText

Hadsell1 downloads
• Download Hadsell1 project data set     one row per animal, one column per trait
• Download Hadsell1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Darryl L Hadsell       Baylor College of Medicine Houston, TX
With: Wei J, Olea W, Hadsell LA, Renwick A, Thomson PC, Shariflou M, Williamson P
ContactDarryl L Hadsell     dhadsell@bcm.edu     Lab web site
AcknowledgementsFunding provided by NIH HD059746; USDA/ARS (#6250-51000-054).
Project type Phenotype strain survey data set
MPD identifiersHadsell1     MPD:494
Data changelog No updates/corrections.       Initial release date: 12/2013.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
This study used a litter cross-fostering approach to measure milk production and maternal performance. Males and females of each inbred strain were mated, allowing females to complete lactation with their first litter. Females of each inbred strain were then mated with CD-1 males. Biological pups were removed, counted, and replaced with ten neonatal CD-1 pups (day 1), which were weight- and size-normalized. Dams and pups were studied for eight days. Average daily weight gain of litters served as the primary indicator of milk production. The number of pups surviving served as a related indicator of maternal performance.

Summary of procedures that were conducted
• colony observation Maternal nurturing study.
• body weight Daily body weight gain of cross-fostered pups.
Mice: inbred   31 strains   ♀   age 14-18wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Hadsell1 49401 colony observation (none) number of pups born in second litter (biological)   [n]  pups_born inbred 31 f 14-18wks N=10
    Hadsell1 49402 body weight (none) average daily litter weight gain of cross-fostered pups, days 1-8   [g]  pups_gain inbred 31 f 14-18wks N=10
    Hadsell1 49403 colony observation (none) number of cross-fostered pups that survived to day 8 (max=10)   [n]  pups_d8 inbred 31 f 14-18wks N=10
    All boxes