Albers1: Diet-induced changes in plasma phospholipid transfer protein activity, lipids, and lipoproteins in 15 inbred strains of mice (1999)

Albers JJ, Pitman W, Wolfbauer G, Cheung MC, Kennedy H, Tu AY, Marcovina SM, Paigen B. Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains. J Lipid Res. 1999 Feb;40(2):295-301.   PubMed 9925659  


       
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Participants John J Albers       University of Washington Seattle, WA
Beverly Paigen       The Jackson Laboratory Bar Harbor, ME
With: Pitman W, Wolfbauer G, Cheung MC Kennedy H, Tu AY, Marcovina SM
ContactJohn J Albers     jja@u.washington.edu
AcknowledgementsFunding provided by NIH HL30086, HL32087, HL49546, DK02456
Project type Phenotype strain survey data set
MPD identifiersAlbers1     MPD:19
Data changelog No updates/corrections.       Initial release date: 05/2003.
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Plasma phospholipid transfer protein activity and lipoprotein phospholipid parameters were characterized at baseline and then again after 6 wks on high fat diet.

Summary of procedures that were conducted
• lipid profile Cholesterol, HDL, non-HDL, triglycerides, phospholipids. 4h fast, plasma. Baseline vs. high-fat diet (6wks).
• protein activity assessment Phospholipid transfer protein activity. 4h fast.
Mice: inbred   15 strains   ♀♂   age 6-14wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Albers1 1901 lipid profile high-fat diet total cholesterol   [mmol/L]     baseline    after 6wks on diet    Δchange inbred 15 both 6-8wks N=8
    Albers1 1902 lipid profile high-fat diet HDL cholesterol   [mmol/L]     baseline    after 6wks on diet    Δchange inbred 15 both 6-8wks N=8
    Albers1 1903 lipid profile high-fat diet non-HDL cholesterol   [mmol/L]     baseline    after 6wks on diet    Δchange inbred 15 both 6-8wks N=8
    Albers1 1910 lipid profile high-fat diet total phospholipid   [mmol/L]     baseline    after 6wks on diet    Δchange inbred 15 both 6-8wks N=8
    Albers1 1911 lipid profile high-fat diet HDL phospholipid   [mmol/L]     baseline    after 6wks on diet    Δchange inbred 15 both 6-8wks N=8
    Albers1 1912 lipid profile high-fat diet non-HDL phospholipid   [mmol/L]     baseline    after 6wks on diet    Δchange inbred 15 both 6-8wks N=8
    Albers1 1913 protein activity assessment high-fat diet phospholipid transfer protein activity   [µmol/mL/h]     baseline    after 6wks on diet    Δchange inbred 15 both 6-8wks N=8
    Albers1 1922 lipid profile high-fat diet percentage of large HDL particles (10-13 nm)   [%]     baseline    after 6wks on diet    Δchange inbred 15 both 6-8wks N=8
    Albers1 1923 lipid profile high-fat diet HDL peak size   [nm]     baseline    after 6wks on diet    Δchange inbred 15 both 6-8wks N=8
    Albers1 1928 lipid profile high-fat diet triglycerides (4h fast)   [mmol/L]     baseline    after 6wks on diet    Δchange inbred 15 both 6-8wks N=8
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