Project measure / variable:   Paigen2   CHOL_chg

ID, description, units MPD:9912   CHOL_chg   total cholesterol (plasma)   [mg/dL]  fold change  
high-fat diet study
Data set, strains Paigen2   inbred w/CC7   41 strains     sex: both     age: 7-9wks
Procedure lipid profile
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen2 - total cholesterol (plasma) fold change



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested40 strains35 strains
Mean of the strain means3.47   mg/dL 3.32   mg/dL
Median of the strain means2.54   mg/dL 2.17   mg/dL
SD of the strain means± 2.40 ± 3.91
Coefficient of variation (CV)0.693 1.18
Min–max range of strain means1.31   –   14.0   mg/dL 1.25   –   24.3   mg/dL
Mean sample size per strain8.6   mice 8.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 26.1882 26.1882 7.5683 0.0062
strain 33 3469.4937 105.1362 30.384 < 0.0001
sex:strain 33 433.8227 13.1461 3.7992 < 0.0001
Residuals 505 1747.424 3.4602


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 2.06 0.306   10 0.0968 0.149 1.53, 2.41 -0.59
129S1/SvImJ m 1.72 0.227   9 0.0755 0.132 1.43, 2.07 -0.41
A/J f 7.93 2.09   10 0.661 0.263 5.0, 11.5 1.86
A/J m 7.51 4.96   8 1.75 0.66 4.07, 15.9 1.07
AKR/J f 2.53 1.36   12 0.391 0.535 1.51, 6.64 -0.39
BALB/cByJ f 2.25 0.758   11 0.229 0.337 1.31, 3.96 -0.51
BALB/cByJ m 2.17 0.733   8 0.259 0.337 1.53, 3.84 -0.29
BTBR T+ Itpr3tf/J f 1.89 0.335   8 0.118 0.177 1.41, 2.55 -0.66
BTBR T+ Itpr3tf/J m 1.93 0.528   7 0.2 0.274 1.32, 2.7 -0.35
BUB/BnJ f 3.95 1.29   10 0.408 0.326 2.31, 5.93 0.2
BUB/BnJ m 1.9 0.426   5 0.191 0.224 1.36, 2.31 -0.36
C3H/HeJ f 2.46 0.556   10 0.176 0.226 1.46, 3.37 -0.42
C3H/HeJ m 1.59 0.447   8 0.158 0.281 0.788, 2.03 -0.44
C57BL/10J f 1.92 0.237   9 0.0791 0.124 1.38, 2.2 -0.64
C57BL/10J m 1.84 0.543   10 0.172 0.295 0.884, 2.59 -0.38
C57BL/6J f 2.54 0.787   10 0.249 0.31 1.39, 4.09 -0.39
C57BL/6J m 2.43 1.03   10 0.327 0.425 1.09, 4.78 -0.23
C57BLKS/J f 5.13 4.97   9 1.66 0.971 2.03, 18.1 0.69
C57BR/cdJ f 3.55 1.04   10 0.33 0.294 2.74, 5.99 0.04
C57BR/cdJ m 3.04 0.589   10 0.186 0.193 1.84, 3.9 -0.07
C57L/J f 2.81 0.863   10 0.273 0.307 2.13, 4.96 -0.27
C57L/J m 2.88 0.638   10 0.202 0.222 1.84, 4.0 -0.11
C58/J f 5.84 2.14   5 0.959 0.367 3.31, 9.12 0.99
C58/J m 5.72 2.37   7 0.895 0.414 3.28, 9.55 0.62
CAST/EiJ f 6.24 1.74   9 0.58 0.279 4.0, 9.2 1.15
CAST/EiJ m 5.41 2.86   8 1.01 0.529 2.67, 10.0 0.54
CBA/J f 1.7 0.434   8 0.153 0.255 1.18, 2.45 -0.74
CBA/J m 1.45 0.324   8 0.115 0.223 0.984, 1.96 -0.48
CZECHII/EiJ f 1.74 0.642   11 0.194 0.369 0.618, 2.65 -0.72
CZECHII/EiJ m 2.06 1.39   9 0.464 0.676 1.03, 4.93 -0.32
DBA/1J f 2.16 0.878   7 0.332 0.406 0.471, 3.21 -0.54
DBA/1J m 1.91 0.665   8 0.235 0.348 1.31, 3.02 -0.36
DBA/2J f 1.31 0.442   9 0.147 0.339 0.66, 2.01 -0.9
DBA/2J m 1.25 0.232   9 0.0773 0.185 0.934, 1.54 -0.53
FVB/NJ f 1.55 0.229   8 0.0811 0.148 1.31, 2.02 -0.8
FVB/NJ m 1.81 0.235   4 0.117 0.13 1.52, 2.07 -0.39
I/LnJ f 4.46 0.446   5 0.199 0.1 3.82, 5.02 0.41
JF1/MsJ f 2.56 0.792   10 0.25 0.31 1.64, 4.23 -0.38
JF1/MsJ m 3.79 2.28   7 0.863 0.603 1.74, 8.29 0.12
KK/HlJ f 1.5 0.421   7 0.159 0.28 0.77, 2.22 -0.82
LP/J f 2.21 0.532   10 0.168 0.24 1.63, 3.15 -0.52
LP/J m 2.04 0.706   11 0.213 0.347 0.891, 3.41 -0.33
MA/MyJ f 3.6 0.614   10 0.194 0.171 2.9, 4.68 0.06
MA/MyJ m 2.13 0.182   10 0.0575 0.0856 1.85, 2.34 -0.3
MOLF/EiJ f 14.0 4.02   6 1.64 0.287 7.29, 19.3 4.39
MOLF/EiJ m 24.3 8.66   4 4.33 0.356 16.8, 36.2 5.37
MSM/MsJ f 1.39 0.363   5 0.162 0.261 0.853, 1.82 -0.86
MSM/MsJ m 1.6 0.211   11 0.0637 0.132 1.27, 2.07 -0.44
NOD/ShiLtJ f 5.24 2.49   7 0.941 0.475 3.2, 10.7 0.74
NOD/ShiLtJ m 4.43 4.18   4 2.09 0.943 1.8, 10.7 0.29
NON/ShiLtJ f 3.61 0.852   10 0.269 0.236 2.38, 5.32 0.06
NON/ShiLtJ m 2.17 0.495   12 0.143 0.228 1.64, 3.15 -0.29
NZB/BlNJ f 2.48 0.411   11 0.124 0.166 1.88, 3.13 -0.41
NZB/BlNJ m 2.32 0.301   9 0.1 0.13 1.87, 2.73 -0.25
NZW/LacJ f 1.98 0.366   9 0.122 0.185 1.44, 2.7 -0.62
NZW/LacJ m 1.84 0.29   8 0.103 0.158 1.38, 2.31 -0.38
PERA/EiJ f 5.67 2.77   9 0.925 0.489 2.51, 12.0 0.92
PERA/EiJ m 5.42 0.937   8 0.331 0.173 4.0, 6.5 0.54
PL/J f 2.89 0.636   10 0.201 0.22 2.21, 4.24 -0.24
PWK/PhJ m 2.37 0.381   8 0.135 0.161 1.84, 2.9 -0.24
RF/J f 2.4 0.822   7 0.311 0.342 1.62, 3.47 -0.44
RIIIS/J f 5.09 1.05   6 0.429 0.206 3.14, 5.91 0.68
RIIIS/J m 2.8 0.388   8 0.137 0.138 2.1, 3.31 -0.13
SEA/GnJ f 1.99 0.407   9 0.136 0.205 1.26, 2.74 -0.61
SEA/GnJ m 2.32 0.482   7 0.182 0.208 1.71, 3.1 -0.25
SJL/J f 1.82 0.465   9 0.155 0.255 0.951, 2.54 -0.69
SJL/J m 2.58 0.856   12 0.247 0.332 1.18, 4.12 -0.19
SM/J f 3.76 0.957   8 0.338 0.255 2.91, 5.71 0.12
SM/J m 2.95 1.15   9 0.384 0.391 1.54, 4.69 -0.09
SPRET/EiJ f 1.93 0.442   4 0.221 0.229 1.39, 2.36 -0.64
SPRET/EiJ m 1.89 0.459   5 0.205 0.242 1.55, 2.63 -0.36
SWR/J f 3.05 0.692   8 0.245 0.227 2.19, 4.0 -0.17
SWR/J m 2.13 0.45   7 0.17 0.211 1.53, 2.89 -0.3
WSB/EiJ f 7.44 10.2   8 3.6 1.37 2.01, 32.2 1.65
WSB/EiJ m 2.34 0.23   9 0.0766 0.098 2.0, 2.67 -0.25


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 2.0587 0.5882 3.2144 0.903
129S1/SvImJ m 1.7234 0.6201 2.9416 0.5052
A/J f 7.9282 0.5882 9.0839 6.7725
A/J m 7.5125 0.6577 8.8046 6.2204
BALB/cByJ f 2.2515 0.5609 3.3534 1.1496
BALB/cByJ m 2.1728 0.6577 3.4649 0.8807
BTBR T+ Itpr3tf/J f 1.8888 0.6577 3.1809 0.5967
BTBR T+ Itpr3tf/J m 1.9254 0.7031 3.3067 0.5441
BUB/BnJ f 3.9475 0.5882 5.1032 2.7918
BUB/BnJ m 1.9048 0.8319 3.5392 0.2704
C3H/HeJ f 2.4617 0.5882 3.6174 1.306
C3H/HeJ m 1.5885 0.6577 2.8806 0.2964
C57BL/10J f 1.9194 0.6201 3.1376 0.7012
C57BL/10J m 1.8432 0.5882 2.9989 0.6875
C57BL/6J f 2.5356 0.5882 3.6913 1.3799
C57BL/6J m 2.4337 0.5882 3.5894 1.278
C57BR/cdJ f 3.5489 0.5882 4.7046 2.3932
C57BR/cdJ m 3.043 0.5882 4.1987 1.8873
C57L/J f 2.8074 0.5882 3.9631 1.6517
C57L/J m 2.8769 0.5882 4.0326 1.7212
C58/J f 5.8443 0.8319 7.4787 4.2099
C58/J m 5.7236 0.7031 7.1049 4.3423
CAST/EiJ f 6.2425 0.6201 7.4608 5.0243
CAST/EiJ m 5.4135 0.6577 6.7056 4.1214
CBA/J f 1.6982 0.6577 2.9903 0.4061
CBA/J m 1.4546 0.6577 2.7467 0.1625
CZECHII/EiJ f 1.7389 0.5609 2.8408 0.637
CZECHII/EiJ m 2.0616 0.6201 3.2798 0.8434
DBA/1J f 2.162 0.7031 3.5433 0.7807
DBA/1J m 1.9095 0.6577 3.2016 0.6174
DBA/2J f 1.3051 0.6201 2.5233 0.0869
DBA/2J m 1.2515 0.6201 2.4697 0.0333
FVB/NJ f 1.5509 0.6577 2.843 0.2588
FVB/NJ m 1.8097 0.9301 3.637 0.0
JF1/MsJ f 2.5557 0.5882 3.7114 1.4
JF1/MsJ m 3.7857 0.7031 5.167 2.4044
LP/J f 2.2146 0.5882 3.3703 1.0589
LP/J m 2.0356 0.5609 3.1375 0.9336
MA/MyJ f 3.6023 0.5882 4.758 2.4466
MA/MyJ m 2.1265 0.5882 3.2822 0.9708
MOLF/EiJ f 14.0133 0.7594 15.5053 12.5213
MOLF/EiJ m 24.3097 0.9301 26.137 22.4824
MSM/MsJ f 1.394 0.8319 3.0284 0.0
MSM/MsJ m 1.6043 0.5609 2.7062 0.5024
NOD/ShiLtJ f 5.2359 0.7031 6.6172 3.8546
NOD/ShiLtJ m 4.4301 0.9301 6.2574 2.6027
NON/ShiLtJ f 3.6087 0.5882 4.7644 2.453
NON/ShiLtJ m 2.1729 0.537 3.2279 1.1179
NZB/BlNJ f 2.482 0.5609 3.5839 1.3801
NZB/BlNJ m 2.3242 0.6201 3.5424 1.106
NZW/LacJ f 1.976 0.6201 3.1942 0.7577
NZW/LacJ m 1.8362 0.6577 3.1283 0.5441
PERA/EiJ f 5.6702 0.6201 6.8884 4.452
PERA/EiJ m 5.4184 0.6577 6.7105 4.1263
RIIIS/J f 5.0855 0.7594 6.5775 3.5935
RIIIS/J m 2.804 0.6577 4.0961 1.5119
SEA/GnJ f 1.9902 0.6201 3.2084 0.772
SEA/GnJ m 2.32 0.7031 3.7013 0.9387
SJL/J f 1.8231 0.6201 3.0413 0.6049
SJL/J m 2.5751 0.537 3.6301 1.5201
SM/J f 3.7584 0.6577 5.0505 2.4663
SM/J m 2.9479 0.6201 4.1661 1.7297
SPRET/EiJ f 1.9302 0.9301 3.7575 0.1028
SPRET/EiJ m 1.8942 0.8319 3.5286 0.2598
SWR/J f 3.051 0.6577 4.3431 1.7589
SWR/J m 2.1342 0.7031 3.5155 0.7529
WSB/EiJ f 7.4429 0.6577 8.735 6.1508
WSB/EiJ m 2.3432 0.6201 3.5614 1.125


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 1.891 0.4273 2.7306 1.0514
A/J both 7.7203 0.4412 8.5871 6.8536
BALB/cByJ both 2.2121 0.4322 3.0612 1.3631
BTBR T+ Itpr3tf/J both 1.9071 0.4814 2.8528 0.9614
BUB/BnJ both 2.9261 0.5094 3.927 1.9253
C3H/HeJ both 2.0251 0.4412 2.8919 1.1583
C57BL/10J both 1.8813 0.4273 2.7209 1.0417
C57BL/6J both 2.4846 0.4159 3.3018 1.6674
C57BR/cdJ both 3.2959 0.4159 4.1131 2.4787
C57L/J both 2.8422 0.4159 3.6594 2.025
C58/J both 5.784 0.5446 6.8539 4.714
CAST/EiJ both 5.828 0.4519 6.7159 4.9401
CBA/J both 1.5764 0.465 2.4901 0.6627
CZECHII/EiJ both 1.9003 0.418 2.7216 1.0789
DBA/1J both 2.0358 0.4814 2.9815 1.09
DBA/2J both 1.2783 0.4384 2.1397 0.4169
FVB/NJ both 1.6803 0.5696 2.7993 0.5613
JF1/MsJ both 3.1707 0.4584 4.0712 2.2702
LP/J both 2.1251 0.4064 2.9235 1.3267
MA/MyJ both 2.8644 0.4159 3.6816 2.0472
MOLF/EiJ both 19.1615 0.6004 20.341 17.982
MSM/MsJ both 1.4991 0.5017 2.4847 0.5136
NOD/ShiLtJ both 4.833 0.583 5.9783 3.6877
NON/ShiLtJ both 2.8908 0.3982 3.6732 2.1084
NZB/BlNJ both 2.4031 0.418 3.2244 1.5818
NZW/LacJ both 1.9061 0.4519 2.794 1.0182
PERA/EiJ both 5.5443 0.4519 6.4322 4.6564
RIIIS/J both 3.9448 0.5023 4.9316 2.9579
SEA/GnJ both 2.1551 0.4687 3.076 1.2342
SJL/J both 2.1991 0.4101 3.0049 1.3933
SM/J both 3.3532 0.4519 4.2411 2.4653
SPRET/EiJ both 1.9122 0.6239 3.138 0.6864
SWR/J both 2.5926 0.4814 3.5383 1.6469
WSB/EiJ both 4.8931 0.4519 5.781 4.0052




  GWAS USING LINEAR MIXED MODELS