Project measure / variable:   CSNA03   dist_l60_cocaine_in_d12

ID, description, units MPD:90427   dist_l60_cocaine_in_d12   distance traveled, last 60 min (post-injection), on successive days, cocaine sensitization, founders   [cm]  day 12 (saline)  
cocaine study
Data set, strains CSNA03   inbred w/CC8   10 strains     sex: both     age: 8-14wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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CSNA03 - distance traveled, last 60 min (post-injection), on successive days, cocaine sensitization, founders day 12 (saline)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means10383.0   cm 11066.0   cm
Median of the strain means8383.0   cm 10612.0   cm
SD of the strain means± 8888.0 ± 8127.0
Coefficient of variation (CV)0.8561 0.7344
Min–max range of strain means670.7   –   23546.0   cm 1254.0   –   26765.0   cm
Mean sample size per strain6.1   mice 6.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1364811.0174 1364811.0174 0.0172 0.8959
strain 8 8434681255.0649 1054335156.8831 13.2866 < 0.0001
sex:strain 8 588573555.4042 73571694.4255 0.9271 0.4974
Residuals 104 8252711457.8665 79352994.7872


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 670.7 1391.0   6 568.0 2.0743 -1.09
129S1/SvImJ m 1254.0 1566.0   6 639.5 1.2493 73.39, 4260.0 -1.21
A/J f 2244.0 912.2   12 263.3 0.4064 1071.0, 3940.0 -0.92
A/J m 3106.0 2067.0   12 596.6 0.6654 1126.0, 8606.0 -0.98
C57BL/6J f 11247.0 1869.0   5 835.7 0.1662 8961.0, 13043.0 0.1
C57BL/6J m 10756.0 4179.0   7 1579.0 0.3885 7668.0, 17822.0 -0.04
C57BL/6NJ f 2754.0 0.0   1   0.0 0.0 2754.0, 2754.0 -0.86
C57BL/6NJ m 7869.0 0.0   1   0.0 0.0 7869.0, 7869.0 -0.39
CAST/EiJ f 23546.0 11148.0   6 4551.0 0.4735 12193.0, 43820.0 1.48
CAST/EiJ m 15501.0 3281.0   5 1467.0 0.2116 12139.0, 20616.0 0.55
DBA/2J f 5519.0 557.9   3 322.1 0.1011 4912.0, 6009.0 -0.55
DBA/2J m 10469.0 7732.0   4 3866.0 0.7386 4514.0, 20995.0 -0.07
NOD/ShiLtJ f 15655.0 7358.0   6 3004.0 0.47 8045.0, 28169.0 0.59
NOD/ShiLtJ m 17980.0 10233.0   6 4178.0 0.5691 7284.0, 32628.0 0.85
NZO/HlLtJ f 1831.0 613.4   6 250.4 0.335 1404.0, 2995.0 -0.96
NZO/HlLtJ m 1523.0 394.2   7 149.0 0.2588 1088.0, 2224.0 -1.17
PWK/PhJ f 19260.0 7000.0   9 2333.0 0.3634 9138.0, 30868.0 1.0
PWK/PhJ m 26765.0 28231.0   8 9981.0 1.0548 7599.0, 94420.0 1.93
WSB/EiJ f 21099.0 7988.0   7 3019.0 0.3786 11198.0, 36952.0 1.21
WSB/EiJ m 15441.0 3175.0   7 1200.0 0.2057 10802.0, 18473.0 0.54


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 670.7333333334 3636.6879342605 7882.4219790826 -6540.9553124159
129S1/SvImJ m 1253.8316666667 3636.6879342605 8465.5203124159 -5957.8569790826
A/J f 2244.3333333333 2571.5266993749 7343.7672785487 -2855.100611882
A/J m 3106.0 2571.5266993749 8205.4339452153 -1993.4339452153
C57BL/6J f 11246.8 3983.7920324027 19146.8090979615 3346.7909020385
C57BL/6J m 10756.2857142857 3366.9187861387 17433.0120158219 4079.5594127496
CAST/EiJ f 23546.1666666667 3636.6879342605 30757.8553124159 16334.4780209174
CAST/EiJ m 15500.6 3983.7920324027 23400.6090979615 7600.5909020385
DBA/2J f 5519.3333333333 5143.0533987499 15718.201223764 -4679.5345570973
DBA/2J m 10468.75 4454.0148963373 19301.2286829544 1636.2713170457
NOD/ShiLtJ f 15655.0 3636.6879342605 22866.6886457492 8443.3113542508
NOD/ShiLtJ m 17980.5 3636.6879342605 25192.1886457492 10768.8113542508
NZO/HlLtJ f 1830.8333333333 3636.6879342605 9042.5219790826 -5380.8553124159
NZO/HlLtJ m 1523.0 3366.9187861387 8199.7263015362 -5153.7263015361
PWK/PhJ f 19259.8888888889 2969.3432642248 25148.2080108584 13371.5697669193
PWK/PhJ m 26765.375 3149.464136706 33010.8805714026 20519.8694285973
WSB/EiJ f 21098.5714285714 3366.9187861387 27775.2977301076 14421.8451270353
WSB/EiJ m 15440.5714285714 3366.9187861387 22117.2977301076 8763.8451270353


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 962.2825 2571.5266993749 6061.7164452153 -4137.1514452153
A/J both 2675.1666666667 1818.3439671303 6281.0109895413 -930.6776562079
C57BL/6J both 11001.5428571429 2608.0040773496 16173.3128117498 5829.772902536
CAST/EiJ both 19523.3833333333 2697.0399556102 24871.7147757344 14175.0518909323
DBA/2J both 7994.0416666667 3401.8100681544 14739.958689787 1248.1246435463
NOD/ShiLtJ both 16817.75 2571.5266993749 21917.1839452153 11718.3160547847
NZO/HlLtJ both 1676.9166666667 2477.9851312937 6590.8541720907 -3237.0208387574
PWK/PhJ both 23012.6319444444 2164.2622166223 27304.4451371572 18720.8187517317
WSB/EiJ both 18269.5714285714 2380.7711053831 22990.7298725142 13548.4129846286




  GWAS USING LINEAR MIXED MODELS