Project measure / variable:   CSNA03   dist_l60_cocaine_in_d5

ID, description, units MPD:90403   dist_l60_cocaine_in_d5   distance traveled, last 60 min (post-injection), on successive days, cocaine sensitization, founders   [cm]  day 5  
cocaine study
Data set, strains CSNA03   inbred w/CC8   10 strains     sex: both     age: 8-14wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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CSNA03 - distance traveled, last 60 min (post-injection), on successive days, cocaine sensitization, founders day 5



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means19174.0   cm 18860.0   cm
Median of the strain means15858.0   cm 19850.0   cm
SD of the strain means± 15000.0 ± 14079.0
Coefficient of variation (CV)0.7823 0.7465
Min–max range of strain means1768.0   –   42965.0   cm 2061.0   –   39898.0   cm
Mean sample size per strain6.2   mice 6.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 30318362.3904 30318362.3904 0.3652 0.5469
strain 8 25751893802.3245 3218986725.2906 38.7735 < 0.0001
sex:strain 8 955043062.8258 119380382.8532 1.438 0.1893
Residuals 106 8800138967.8413 83020178.9419


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 4319.0 10070.0   6 4111.0 2.3314 -0.99
129S1/SvImJ m 2061.0 2808.0   6 1146.0 1.3621 73.13, 7613.0 -1.19
A/J f 1768.0 1309.0   12 377.9 0.7404 165.1, 4494.0 -1.16
A/J m 2491.0 2728.0   12 787.5 1.0953 62.23, 9653.0 -1.16
C57BL/6J f 14305.0 7432.0   6 3034.0 0.5195 -0.32
C57BL/6J m 16660.0 8343.0   7 3153.0 0.5008 5685.0, 28572.0 -0.16
C57BL/6NJ f 5417.0 0.0   1   0.0 0.0 5417.0, 5417.0 -0.92
C57BL/6NJ m 5456.0 0.0   1   0.0 0.0 5456.0, 5456.0 -0.95
CAST/EiJ f 35313.0 15056.0   6 6146.0 0.4263 26035.0, 64914.0 1.08
CAST/EiJ m 34122.0 12202.0   5 5457.0 0.3576 13438.0, 43690.0 1.08
DBA/2J f 17410.0 1434.0   3 827.7 0.0823 15946.0, 18811.0 -0.12
DBA/2J m 23040.0 7884.0   4 3942.0 0.3422 14597.0, 33573.0 0.3
NOD/ShiLtJ f 26376.0 7224.0   6 2949.0 0.2739 17892.0, 34479.0 0.48
NOD/ShiLtJ m 29863.0 11524.0   6 4705.0 0.3859 13707.0, 46028.0 0.78
NZO/HlLtJ f 7934.0 3209.0   6 1310.0 0.4044 2442.0, 10492.0 -0.75
NZO/HlLtJ m 6741.0 3761.0   7 1422.0 0.5579 3008.0, 13678.0 -0.86
PWK/PhJ f 35928.0 8794.0   9 2931.0 0.2448 21124.0, 48744.0 1.12
PWK/PhJ m 39898.0 10770.0   9 3590.0 0.2699 23600.0, 57534.0 1.49
WSB/EiJ f 42965.0 17953.0   7 6786.0 0.4179 18325.0, 66246.0 1.59
WSB/EiJ m 28266.0 12897.0   7 4874.0 0.4562 10950.0, 43802.0 0.67


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 4319.1471666667 3719.7710265978 11693.9550183941 -3055.6606850608
129S1/SvImJ m 2061.4216666667 3719.7710265978 9436.2295183941 -5313.3861850608
A/J f 1768.0666666667 2630.2753173686 6982.8433085709 -3446.7099752376
A/J m 2490.6866666667 2630.2753173686 7705.463308571 -2724.0899752376
C57BL/6J f 14305.0 3719.7710265978 21679.8078517275 6930.1921482726
C57BL/6J m 16659.8571428572 3443.8387829758 23487.6024839469 9832.1118017675
CAST/EiJ f 35313.0000000001 3719.7710265978 42687.8078517275 27938.1921482726
CAST/EiJ m 34121.6000000001 4074.8050000435 42200.2972353147 26042.9027646854
DBA/2J f 17410.0 5260.5506347371 27839.5532838086 6980.4467161915
DBA/2J m 23040.0 4555.7704875767 32072.2580939017 14007.7419060984
NOD/ShiLtJ f 26376.3333333333 3719.7710265978 33751.1411850608 19001.5254816059
NOD/ShiLtJ m 29863.1666666667 3719.7710265978 37237.9745183941 22488.3588149392
NZO/HlLtJ f 7934.3333333334 3719.7710265978 15309.1411850608 559.5254816059
NZO/HlLtJ m 6741.2857142857 3443.8387829758 13569.0310553755 -86.459626804
PWK/PhJ f 35927.5555555555 3037.1803250511 41949.06095149 29906.0501596211
PWK/PhJ m 39897.6666666667 3037.1803250511 45919.1720626011 33876.1612707322
WSB/EiJ f 42965.0 3443.8387829758 49792.7453410897 36137.2546589103
WSB/EiJ m 28266.4285714286 3443.8387829758 35094.1739125183 21438.6832303389


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3190.2844166667 2630.2753173686 8405.061058571 -2024.4922252376
A/J both 2129.3766666667 1859.8855132989 5816.7805925304 -1558.0272591971
C57BL/6J both 15482.4285714286 2534.596716119 20507.513080486 10457.3440623712
CAST/EiJ both 34717.3000000001 2758.6560259797 40186.6038832603 29247.9961167398
DBA/2J both 20225.0 3479.5271846943 27123.5010686136 13326.4989313864
NOD/ShiLtJ both 28119.75 2630.2753173686 33334.5266419043 22904.9733580957
NZO/HlLtJ both 7337.8095238096 2534.596716119 12362.8940328669 2312.7250147522
PWK/PhJ both 37912.6111111111 2147.61080353 42170.4584095277 33654.7638126945
WSB/EiJ both 35615.7142857143 2435.1617567554 40443.6593166137 30787.7692548149




  GWAS USING LINEAR MIXED MODELS