Project measure / variable:   CSNA03   dist_l60_cocaine_in_d3

ID, description, units MPD:90397   dist_l60_cocaine_in_d3   distance traveled, last 60 min (post-injection), on successive days, cocaine sensitization, founders   [cm]  day 3  
cocaine study
Data set, strains CSNA03   inbred w/CC8   10 strains     sex: both     age: 8-14wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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CSNA03 - distance traveled, last 60 min (post-injection), on successive days, cocaine sensitization, founders day 3



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means16447.0   cm 16916.0   cm
Median of the strain means9298.0   cm 16488.0   cm
SD of the strain means± 14704.0 ± 13099.0
Coefficient of variation (CV)0.894 0.7744
Min–max range of strain means2955.0   –   41378.0   cm 2120.0   –   37498.0   cm
Mean sample size per strain6.0   mice 6.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 12076498.0802 12076498.0802 0.1593 0.6906
strain 8 22720929035.6001 2840116129.45 37.4591 < 0.0001
sex:strain 8 1289207574.9116 161150946.8639 2.1255 0.0397
Residuals 104 7885196261.1019 75819194.8183


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3334.0 7786.0   6 3179.0 2.3351 -0.89
129S1/SvImJ m 2199.0 1809.0   6 738.7 0.8229 760.4, 5750.0 -1.12
A/J f 2955.0 2499.0   12 721.4 0.8456 143.4, 9456.0 -0.92
A/J m 2120.0 1273.0   12 367.5 0.6004 166.8, 4788.0 -1.13
C57BL/6J f 12490.0 912.7   5 408.2 0.0731 11628.0, 13895.0 -0.27
C57BL/6J m 14106.0 4868.0   7 1840.0 0.3451 5400.0, 20553.0 -0.21
C57BL/6NJ f 6105.0 0.0   1   0.0 0.0 6105.0, 6105.0 -0.7
C57BL/6NJ m 5209.0 0.0   1   0.0 0.0 5209.0, 5209.0 -0.89
CAST/EiJ f 35390.0 17575.0   6 7175.0 0.4966 18616.0, 68608.0 1.29
CAST/EiJ m 22258.0 10160.0   5 4544.0 0.4565 10106.0, 34998.0 0.41
DBA/2J f 4892.0 4350.0   2   3076.0 0.8892 1816.0, 7968.0 -0.79
DBA/2J m 18870.0 9324.0   4 4662.0 0.4942 5353.0, 26451.0 0.15
NOD/ShiLtJ f 21848.0 4965.0   6 2027.0 0.2273 14464.0, 28392.0 0.37
NOD/ShiLtJ m 27766.0 12916.0   6 5273.0 0.4652 12838.0, 51242.0 0.83
NZO/HlLtJ f 5366.0 2697.0   6 1101.0 0.5026 2505.0, 8645.0 -0.75
NZO/HlLtJ m 5856.0 5500.0   7 2079.0 0.9391 1654.0, 14331.0 -0.84
PWK/PhJ f 30709.0 7986.0   9 2662.0 0.2601 18553.0, 39809.0 0.97
PWK/PhJ m 37498.0 16757.0   9 5586.0 0.4469 15106.0, 62228.0 1.57
WSB/EiJ f 41378.0 9998.0   7 3779.0 0.2416 20152.0, 48795.0 1.7
WSB/EiJ m 33281.0 9704.0   7 3668.0 0.2916 20936.0, 48277.0 1.25


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3334.3116666667 3554.7900739305 10383.5937820427 -3714.9704487093
129S1/SvImJ m 2198.7333333333 3554.7900739305 9248.0154487093 -4850.5487820426
A/J f 2955.3333333333 2513.6161669709 7939.9285196127 -2029.2618529461
A/J m 2120.25 2513.6161669709 7104.8451862794 -2864.3451862794
C57BL/6J f 12490.0 3894.0774213744 20212.1016576183 4767.8983423817
C57BL/6J m 14105.7142857143 3291.0961009168 20632.0813570966 7579.3472143321
CAST/EiJ f 35390.0 3554.7900739305 42439.282115376 28340.717884624
CAST/EiJ m 22258.1999999999 3894.0774213744 29980.3016576183 14536.0983423816
DBA/2J f 4892.0 6157.0770182891 17101.7147807179 -7317.7147807178
DBA/2J m 18869.5 4353.7109119201 27503.0721177992 10235.9278822008
NOD/ShiLtJ f 21847.8333333333 3554.7900739305 28897.1154487093 14798.5512179573
NOD/ShiLtJ m 27766.0 3554.7900739305 34815.282115376 20716.717884624
NZO/HlLtJ f 5365.6666666667 3554.7900739305 12414.9487820427 -1683.6154487093
NZO/HlLtJ m 5856.2857142857 3291.0961009168 12382.652785668 -670.0813570965
PWK/PhJ f 30708.8888888889 2902.47394128 36464.6036340884 24953.1741436894
PWK/PhJ m 37498.3333333333 2902.47394128 43254.0480785328 31742.6185881339
WSB/EiJ f 41378.0 3291.0961009168 47904.3670713823 34851.6329286177
WSB/EiJ m 33280.8571428572 3291.0961009168 39807.2242142394 26754.4900714749


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 2766.5225 2513.6161669709 7751.1176862794 -2218.0726862794
A/J both 2537.7916666667 1777.3950369652 6062.4327243547 -986.8493910213
C57BL/6J both 13297.8571428572 2549.2720779238 18353.1593385972 8242.5549471172
CAST/EiJ both 28824.1 2636.3028768226 34051.9875359162 23596.2124640838
DBA/2J both 11880.75 3770.4242504563 19357.6427794192 4403.8572205809
NOD/ShiLtJ both 24806.9166666666 2513.6161669709 29791.511852946 19822.3214803872
NZO/HlLtJ both 5610.9761904762 2422.1811459501 10414.2522988366 807.7000821158
PWK/PhJ both 34103.6111111111 2052.3590060964 38173.5160380171 30033.7061842052
WSB/EiJ both 37329.4285714286 2327.1563704949 41944.2669841156 32714.5901587416




  GWAS USING LINEAR MIXED MODELS