Project measure / variable:   CSNA03   dist_l60_cocaine_in_d2

ID, description, units MPD:90391   dist_l60_cocaine_in_d2   distance traveled, last 60 min (post-injection), on successive days, cocaine sensitization, founders   [cm]  day 2 (saline)  
cocaine study
Data set, strains CSNA03   inbred w/CC8   10 strains     sex: both     age: 8-14wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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CSNA03 - distance traveled, last 60 min (post-injection), on successive days, cocaine sensitization, founders day 2 (saline)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means10018.0   cm 8677.0   cm
Median of the strain means7287.0   cm 8154.0   cm
SD of the strain means± 8756.0 ± 5865.0
Coefficient of variation (CV)0.874 0.6759
Min–max range of strain means309.7   –   22350.0   cm 437.0   –   17760.0   cm
Mean sample size per strain6.2   mice 6.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 89015127.6155 89015127.6155 2.9884 0.0868
strain 8 6627524607.8686 828440575.9836 27.8127 < 0.0001
sex:strain 8 430129836.5896 53766229.5737 1.8051 0.0842
Residuals 105 3127573605.3363 29786415.2889


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 309.7 541.8   6 221.2 1.7492 -1.11
129S1/SvImJ m 437.0 502.0   6 205.0 1.1487 6.35, 1269.0 -1.4
A/J f 1660.0 986.0   12 284.6 0.5938 225.5, 3674.0 -0.95
A/J m 5291.0 11350.0   12 3276.0 2.145 308.9, 41260.0 -0.58
C57BL/6J f 9395.0 583.0   6 238.0 0.0621 8506.0, 9956.0 -0.07
C57BL/6J m 10025.0 1778.0   6 725.7 0.1773 8211.0, 12372.0 0.23
C57BL/6NJ f 4781.0 0.0   1   0.0 0.0 4781.0, 4781.0 -0.6
C57BL/6NJ m 6283.0 0.0   1   0.0 0.0 6283.0, 6283.0 -0.41
CAST/EiJ f 20073.0 5714.0   6 2333.0 0.2847 12656.0, 27257.0 1.15
CAST/EiJ m 11841.0 3517.0   5 1573.0 0.297 8747.0, 17518.0 0.54
DBA/2J f 5179.0 2153.0   3 1243.0 0.4158 2906.0, 7188.0 -0.55
DBA/2J m 5963.0 3190.0   4 1595.0 0.535 2887.0, 10068.0 -0.46
NOD/ShiLtJ f 15422.0 4868.0   6 1987.0 0.3156 7679.0, 20030.0 0.62
NOD/ShiLtJ m 13960.0 3865.0   6 1578.0 0.2769 7788.0, 19427.0 0.9
NZO/HlLtJ f 713.1 293.1   6 119.7 0.411 401.1, 1184.0 -1.06
NZO/HlLtJ m 801.5 328.1   7 124.0 0.4093 198.2, 1154.0 -1.34
PWK/PhJ f 22350.0 5984.0   9 1995.0 0.2677 11665.0, 34046.0 1.41
PWK/PhJ m 17760.0 9764.0   9 3255.0 0.5498 4623.0, 35054.0 1.55
WSB/EiJ f 20297.0 4310.0   7 1629.0 0.2123 13041.0, 25894.0 1.17
WSB/EiJ m 14410.0 3468.0   7 1311.0 0.2407 9390.0, 21087.0 0.98


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 309.7166666667 2228.0939271388 4727.6153368475 -4108.1820035142
129S1/SvImJ m 437.0416666667 2228.0939271388 4854.9403368475 -3980.8570035142
A/J f 1660.35 1575.5003250004 4784.2761082799 -1463.5761082799
A/J m 5291.2416666667 1575.5003250004 8415.1677749466 2167.3155583868
C57BL/6J f 9395.0 2228.0939271388 13812.8986701808 4977.1013298191
C57BL/6J m 10024.8333333333 2228.0939271388 14442.7320035142 5606.9346631525
CAST/EiJ f 20072.8333333333 2228.0939271388 24490.7320035142 15654.9346631525
CAST/EiJ m 11840.6 2440.7546082684 16680.1655168603 7001.0344831397
DBA/2J f 5178.6666666667 3151.0006500009 11426.5188832265 -1069.1855498932
DBA/2J m 5963.0 2728.846610242 11373.7987386317 552.2012613683
NOD/ShiLtJ f 15422.3333333333 2228.0939271388 19840.2320035142 11004.4346631525
NOD/ShiLtJ m 13959.8333333333 2228.0939271388 18377.7320035142 9541.9346631525
NZO/HlLtJ f 713.05 2228.0939271388 5130.9486701808 -3704.8486701808
NZO/HlLtJ m 801.5285714286 2062.8141419263 4891.7079590404 -3288.6508161833
PWK/PhJ f 22350.0 1819.2310734947 25957.1991590878 18742.8008409122
PWK/PhJ m 17760.1111111111 1819.2310734947 21367.3102701989 14152.9119520233
WSB/EiJ f 20297.0 2062.8141419263 24387.1793876119 16206.8206123881
WSB/EiJ m 14409.7142857143 2062.8141419263 18499.8936733262 10319.5348981024


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 373.3791666667 1575.5003250004 3497.3052749466 -2750.5469416132
A/J both 3475.7958333333 1114.0469635694 5684.7451684238 1266.8464982429
C57BL/6J both 9709.9166666667 1575.5003250004 12833.8427749466 6585.9905583868
CAST/EiJ both 15956.7166666667 1652.3986811554 19233.1180100604 12680.315323273
DBA/2J both 5570.8333333333 2084.1910252263 9703.3991316586 1438.2675350081
NOD/ShiLtJ both 14691.0833333333 1575.5003250004 17815.0094416132 11567.1572250534
NZO/HlLtJ both 757.2892857143 1518.1901010977 3767.5798066952 -2253.0012352666
PWK/PhJ both 20055.0555555556 1286.3906286134 22605.730542037 17504.3805690742
WSB/EiJ both 17353.3571428571 1458.6298680836 20245.5507241069 14461.1635616074




  GWAS USING LINEAR MIXED MODELS