Project measure / variable:   CSNA03   dist_l60_cocaine_in_d1

ID, description, units MPD:90385   dist_l60_cocaine_in_d1   distance traveled, last 60 min (post-injection), on successive days, cocaine sensitization, founders   [cm]  day 1 (saline)  
cocaine study
Data set, strains CSNA03   inbred w/CC8   10 strains     sex: both     age: 8-14wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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CSNA03 - distance traveled, last 60 min (post-injection), on successive days, cocaine sensitization, founders day 1 (saline)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means11122.0   cm 8572.0   cm
Median of the strain means11548.0   cm 6404.0   cm
SD of the strain means± 7619.0 ± 6852.0
Coefficient of variation (CV)0.6851 0.7994
Min–max range of strain means201.9   –   22714.0   cm 995.9   –   18320.0   cm
Mean sample size per strain6.2   mice 6.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 222310135.9188 222310135.9188 3.1045 0.081
strain 8 5581243934.0717 697655491.759 9.7425 < 0.0001
sex:strain 8 752305286.9225 94038160.8653 1.3132 0.2448
Residuals 106 7590592688.589 71609364.9867


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 201.9 373.2   6 152.4 1.8485 -1.43
129S1/SvImJ m 995.9 968.6   6 395.4 0.9726 -1.11
A/J f 2927.0 1349.0   12 389.3 0.4608 1519.0, 5798.0 -1.08
A/J m 3101.0 1744.0   12 503.4 0.5623 63.75, 5841.0 -0.8
C57BL/6J f 7890.0 1520.0   6 620.6 0.1927 5460.0, 9436.0 -0.42
C57BL/6J m 8081.0 1705.0   7 644.6 0.211 5357.0, 10162.0 -0.07
C57BL/6NJ f 4490.0 0.0   1   0.0 0.0 4490.0, 4490.0 -0.87
C57BL/6NJ m 3554.0 0.0   1   0.0 0.0 3554.0, 3554.0 -0.73
CAST/EiJ f 17873.0 4898.0   6 1999.0 0.274 11217.0, 24034.0 0.89
CAST/EiJ m 12751.0 2681.0   5 1199.0 0.2103 9868.0, 17033.0 0.61
DBA/2J f 6521.0 2256.0   3 1302.0 0.3459 4765.0, 9065.0 -0.6
DBA/2J m 4726.0 2175.0   4 1087.0 0.4601 2909.0, 7661.0 -0.56
NOD/ShiLtJ f 15789.0 3087.0   6 1260.0 0.1955 10378.0, 19165.0 0.61
NOD/ShiLtJ m 18000.0 3988.0   6 1628.0 0.2215 12916.0, 24546.0 1.38
NZO/HlLtJ f 15207.0 34772.0   6 14196.0 2.2866 486.1, 86181.0 0.54
NZO/HlLtJ m 1266.0 562.8   7 212.7 0.4447 725.8, 2387.0 -1.07
PWK/PhJ f 17608.0 3270.0   9 1090.0 0.1857 13143.0, 23283.0 0.85
PWK/PhJ m 18320.0 6925.0   9 2308.0 0.378 9132.0, 28995.0 1.42
WSB/EiJ f 22714.0 8053.0   7 3044.0 0.3545 13719.0, 37922.0 1.52
WSB/EiJ m 14921.0 7033.0   7 2658.0 0.4714 3931.0, 27505.0 0.93


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 201.9 3454.6916164034 7051.1621389257 -6647.3621389256
129S1/SvImJ m 995.8833333333 3454.6916164034 7845.145472259 -5853.3788055924
A/J f 2927.0833333333 2442.8358688672 7770.243037892 -1916.0763712253
A/J m 3101.1458333333 2442.8358688672 7944.3055378919 -1742.0138712253
C57BL/6J f 7890.3333333333 3454.6916164034 14739.595472259 1041.0711944077
C57BL/6J m 8081.1428571429 3198.422936982 14422.3274139714 1739.9583003143
CAST/EiJ f 17872.6666666667 3454.6916164034 24721.9288055924 11023.404527741
CAST/EiJ m 12750.6 3784.4250550563 20253.5907515113 5247.6092484887
DBA/2J f 6521.0 4885.6717377344 16207.3194091173 -3165.3194091172
DBA/2J m 4726.25 4231.1158394296 13114.8486774658 -3662.3486774658
NOD/ShiLtJ f 15789.3333333334 3454.6916164034 22638.595472259 8940.0711944077
NOD/ShiLtJ m 18000.5 3454.6916164034 24849.7621389257 11151.2378610743
NZO/HlLtJ f 15206.8166666667 3454.6916164034 22056.0788055924 8357.554527741
NZO/HlLtJ m 1265.6142857143 3198.422936982 7606.7988425428 -5075.5702711142
PWK/PhJ f 17608.2222222222 2820.7438929531 23200.6213405328 12015.8231039117
PWK/PhJ m 18319.6666666666 2820.7438929531 23912.0657849772 12727.2675483561
WSB/EiJ f 22714.0 3198.422936982 29055.1845568286 16372.8154431715
WSB/EiJ m 14921.1428571429 3198.422936982 21262.3274139714 8579.9583003143


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 598.8916666667 2442.8358688672 5442.0513712253 -4244.2680378919
A/J both 3014.1145833333 1727.3458082017 6438.7456527962 -410.5164861295
C57BL/6J both 7985.7380952381 2353.9755440669 12652.7235631682 3318.752627308
CAST/EiJ both 15311.6333333333 2562.0678738953 20391.1820845756 10232.0845820911
DBA/2J both 5623.625 3231.5681013855 12030.5230690156 -783.2730690156
NOD/ShiLtJ both 16894.9166666667 2442.8358688672 21738.0763712253 12051.7569621081
NZO/HlLtJ both 8236.2154761905 2353.9755440669 12903.2009441206 3569.2300082604
PWK/PhJ both 17963.9444444444 1994.5671346977 21918.3677841035 14009.5211047854
WSB/EiJ both 18817.5714285714 2261.6265478426 23301.4660294603 14333.6768276826




  GWAS USING LINEAR MIXED MODELS