Project measure / variable:   GMC20   IgG3_17

ID, description, units MPD:56912   IgG3_17   immunoglobulin G3 (plasma IgG3)   [µg/mL]  at age 16-17wks  
Data set, strains GMC20   inbred w/CC8   6 strains     sex: both     age: 16-17wks
Procedure immunoglobulin quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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GMC20 - immunoglobulin G3 (plasma IgG3) at age 16-17wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested6 strains6 strains
Mean of the strain means286   µg/mL 210   µg/mL
Median of the strain means258   µg/mL 184   µg/mL
SD of the strain means± 137 ± 124
Coefficient of variation (CV)0.479 0.591
Min–max range of strain means130   –   481   µg/mL 77.2   –   402   µg/mL
Mean sample size per strain3.0   mice 3.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 76063.6506 76063.6506 7.7707 0.0102
strain 3 240980.6435 80326.8812 8.2062 0.0006
sex:strain 3 54279.4597 18093.1532 1.8484 0.1654
Residuals 24 234925.7298 9788.5721


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 175.0 73.4   4 36.7 0.418 88.2, 259.0 -0.81
129S1/SvImJ m 204.0 117.0   4 58.4 0.571 48.9, 324.0 -0.05
A/J f 272.0 84.4   4 42.2 0.311 196.0, 388.0 -0.11
A/J m 105.0 20.0   4 10.0 0.191 76.8, 124.0 -0.85
C57BL/6J f 481.0 127.0   4 63.3 0.263 316.0, 592.0 1.42
C57BL/6J m 307.0 144.0   4 72.2 0.471 193.0, 500.0 0.78
NOD/ShiLtJ f 130.0 0.0   1   0.0 0.0 130.0, 130.0 -1.14
NOD/ShiLtJ m 77.2 16.5   2   11.6 0.213 65.6, 88.8 -1.07
NZO/HlLtJ f 243.0 119.0   4 59.4 0.488 118.0, 375.0 -0.32
NZO/HlLtJ m 165.0 27.7   4 13.8 0.167 138.0, 199.0 -0.36
WSB/EiJ f 418.0 0.0   1   0.0 0.0 418.0, 418.0 0.96
WSB/EiJ m 402.0 262.0   3 151.0 0.651 114.0, 626.0 1.55


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 175.33 49.4686 277.4282 73.2318
129S1/SvImJ m 204.485 49.4686 306.5832 102.3868
A/J f 271.54 49.4686 373.6382 169.4418
A/J m 104.8375 49.4686 206.9357 2.7393
C57BL/6J f 481.2775 49.4686 583.3757 379.1793
C57BL/6J m 306.78 49.4686 408.8782 204.6818
NZO/HlLtJ f 243.3325 49.4686 345.4307 141.2343
NZO/HlLtJ m 165.3425 49.4686 267.4407 63.2443


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 189.9075 34.9796 262.1018 117.7132
A/J both 188.1887 34.9796 260.3831 115.9944
C57BL/6J both 394.0287 34.9796 466.2231 321.8344
NZO/HlLtJ both 204.3375 34.9796 276.5318 132.1432




  GWAS USING LINEAR MIXED MODELS