Project measure / variable:   GMC16   LDH_21

ID, description, units MPD:56533   LDH_21   lactic acid dehydrogenase (plasma LDH)   [IU/L]  at age 20-21wks  
Data set, strains GMC16   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure metabolic panel
Ontology mappings

  STRAIN COMPARISON PLOT
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GMC16 - lactic acid dehydrogenase (plasma LDH) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means287   IU/L 280   IU/L
Median of the strain means292   IU/L 262   IU/L
SD of the strain means± 49.5 ± 36.1
Coefficient of variation (CV)0.172 0.129
Min–max range of strain means221   –   359   IU/L 249   –   345   IU/L
Mean sample size per strain8.9   mice 9.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1251.43 1251.43 0.1613 0.6886
strain 7 158710.5579 22672.9368 2.9218 0.0071
sex:strain 7 85283.8773 12183.411 1.57 0.1496
Residuals 133 1032078.6243 7759.9897


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 250.0 66.6   9 22.2 0.267 174.0, 344.0 -0.76
129S1/SvImJ m 249.0 40.4   10 12.8 0.162 185.0, 326.0 -0.85
A/J f 359.0 89.6   10 28.3 0.25 266.0, 526.0 1.45
A/J m 304.0 116.0   11 34.9 0.381 167.0, 563.0 0.67
C57BL/6J f 221.0 79.6   10 25.2 0.36 112.0, 352.0 -1.34
C57BL/6J m 249.0 102.0   12 29.4 0.409 99.7, 410.0 -0.85
CAST/EiJ f 287.0 56.4   10 17.8 0.196 172.0, 361.0 -0.01
CAST/EiJ m 254.0 73.7   7 27.9 0.29 174.0, 336.0 -0.71
NOD/ShiLtJ f 296.0 66.3   9 22.1 0.224 220.0, 437.0 0.17
NOD/ShiLtJ m 345.0 152.0   11 45.8 0.441 220.0, 704.0 1.81
NZO/HlLtJ f 349.0 124.0   6 50.8 0.356 194.0, 548.0 1.25
NZO/HlLtJ m 268.0 43.5   6 17.8 0.163 223.0, 333.0 -0.32
PWK/PhJ f 240.0 45.0   7 17.0 0.188 172.0, 316.0 -0.96
PWK/PhJ m 312.0 73.9   9 24.6 0.237 199.0, 396.0 0.9
WSB/EiJ f 297.0 90.4   10 28.6 0.305 163.0, 479.0 0.19
WSB/EiJ m 256.0 74.3   12 21.4 0.291 121.0, 367.0 -0.65


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 249.7667 29.3636 307.8467 191.6866
129S1/SvImJ m 248.79 27.8568 303.8896 193.6904
A/J f 359.12 27.8568 414.2196 304.0204
A/J m 304.1455 26.5604 356.6809 251.6101
C57BL/6J f 221.09 27.8568 276.1896 165.9904
C57BL/6J m 249.4167 25.4296 299.7155 199.1179
CAST/EiJ f 287.42 27.8568 342.5196 232.3204
CAST/EiJ m 254.3429 33.2952 320.1995 188.4863
NOD/ShiLtJ f 295.7556 29.3636 353.8356 237.6755
NOD/ShiLtJ m 344.7182 26.5604 397.2536 292.1828
NZO/HlLtJ f 349.4667 35.9629 420.5999 278.3334
NZO/HlLtJ m 267.55 35.9629 338.6833 196.4167
PWK/PhJ f 239.6429 33.2952 305.4995 173.7863
PWK/PhJ m 312.0 29.3636 370.0801 253.9199
WSB/EiJ f 296.7 27.8568 351.7996 241.6004
WSB/EiJ m 255.5583 25.4296 305.8571 205.2595


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 249.2783 20.2375 289.3073 209.2494
A/J both 331.6327 19.2448 369.6982 293.5672
C57BL/6J both 235.2533 18.8591 272.5559 197.9507
CAST/EiJ both 270.8814 21.7058 313.8147 227.9482
NOD/ShiLtJ both 320.2369 19.7969 359.3944 281.0793
NZO/HlLtJ both 308.5083 25.4296 358.8071 258.2095
PWK/PhJ both 275.8214 22.1968 319.7258 231.917
WSB/EiJ both 276.1292 18.8591 313.4318 238.8266




  GWAS USING LINEAR MIXED MODELS