Project measure / variable:   Gould2   cotinine_chr

ID, description, units MPD:47106   cotinine_chr   plasma cotinine   [ng/mL]  chronic 6.3mg dose  
nicotine study
Data set, strains Gould2   inbred   8 strains     sex: m     age:
Procedure drug and metabolite quantification
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  STRAIN COMPARISON PLOT
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Gould2 - plasma cotinine chronic 6.3mg dose



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested8 strains
Mean of the strain means106   ng/mL
Median of the strain means89.7   ng/mL
SD of the strain means± 46.4
Coefficient of variation (CV)0.439
Min–max range of strain means59.2   –   181   ng/mL
Mean sample size per strain10.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 7 151407.4749 21629.6393 51.5967 < 0.0001
Residuals 72 30182.849 419.2062


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S6/SvEvTac m 181.0 25.6   10 8.09 0.141 139.0, 216.0 1.62
A/J m 96.6 31.2   10 9.87 0.323 59.8, 142.0 -0.2
BALB/cByJ m 72.8 12.8   10 4.05 0.176 54.4, 91.7 -0.71
C3H/HeJ m 64.3 8.83   10 2.79 0.137 49.3, 76.6 -0.89
C57BL/6J m 59.2 8.86   10 2.8 0.149 39.9, 71.2 -1.0
CBA/J m 82.8 15.5   10 4.91 0.187 56.6, 104.0 -0.49
DBA/1J m 165.0 24.2   10 7.65 0.146 140.0, 212.0 1.28
DBA/2J m 124.0 24.0   10 7.6 0.194 92.6, 172.0 0.39


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S6/SvEvTac m 181.11 6.4746 194.0169 168.2031
A/J m 96.65 6.4746 109.5569 83.7431
BALB/cByJ m 72.79 6.4746 85.6969 59.8831
C3H/HeJ m 64.32 6.4746 77.2269 51.4131
C57BL/6J m 59.24 6.4746 72.1469 46.3331
CBA/J m 82.82 6.4746 95.7269 69.9131
DBA/1J m 165.35 6.4746 178.2569 152.4431
DBA/2J m 124.05 6.4746 136.9569 111.1431




  GWAS USING LINEAR MIXED MODELS