Project measure / variable:   Thomsen1   activ_cocaine2_32

ID, description, units MPD:40710   activ_cocaine2_32   total activity, test 2, 3h test   [n]  dose 32 mg/kg  
cocaine study
Data set, strains Thomsen1   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen1 - total activity, test 2, 3h test dose 32 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means4758   n 4927   n
Median of the strain means4485   n 5056   n
SD of the strain means± 3652 ± 2994
Coefficient of variation (CV)0.768 0.608
Min–max range of strain means558   –   14261   n 823   –   10386   n
Mean sample size per strain7.8   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 134658.0199 134658.0199 0.0193 0.8897
strain 14 2157421405.0379 154101528.9313 22.073 < 0.0001
sex:strain 14 184374655.1944 13169618.2282 1.8864 0.0296
Residuals 201 1403268607.1071 6981435.8563


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 1521.0 432.0   8 153.0 0.284 1079.0, 2117.0 -0.89
129S1/SvImJ m 2017.0 761.0   8 269.0 0.378 758.0, 3005.0 -0.97
129S6/SvEvTac f 558.0 302.0   8 107.0 0.54 159.0, 1030.0 -1.15
129S6/SvEvTac m 823.0 439.0   8 155.0 0.534 293.0, 1558.0 -1.37
129X1/SvJ f 966.0 585.0   8 207.0 0.606 455.0, 2253.0 -1.04
129X1/SvJ m 1281.0 1063.0   8 376.0 0.829 523.0, 3771.0 -1.22
A/J f 1896.0 1047.0   8 370.0 0.553 808.0, 3655.0 -0.78
A/J m 2207.0 1123.0   8 397.0 0.509 992.0, 4653.0 -0.91
BALB/cByJ f 6231.0 1107.0   8 391.0 0.178 4889.0, 8278.0 0.4
BALB/cByJ m 7462.0 1516.0   8 536.0 0.203 4575.0, 9842.0 0.85
BALB/cJ f 5343.0 2337.0   7 883.0 0.437 1557.0, 8404.0 0.16
BALB/cJ m 5056.0 3252.0   8 1150.0 0.643 1173.0, 9949.0 0.04
C3H/HeJ f 1820.0 1426.0   8 504.0 0.784 479.0, 4008.0 -0.8
C3H/HeJ m 5221.0 2261.0   8 799.0 0.433 1201.0, 7978.0 0.1
C57BL/6J f 8517.0 5066.0   7 1915.0 0.595 3193.0, 19221.0 1.03
C57BL/6J m 6124.0 1377.0   8 487.0 0.225 4421.0, 8208.0 0.4
CAST/EiJ f 7810.0 4949.0   8 1750.0 0.634 2394.0, 14455.0 0.84
CAST/EiJ m 10386.0 4984.0   4 2492.0 0.48 5418.0, 16669.0 1.82
Crl:CD-1(ICR) f 4485.0 2883.0   8 1019.0 0.643 1457.0, 9710.0 -0.07
Crl:CD-1(ICR) m 6371.0 4141.0   8 1464.0 0.65 1139.0, 15243.0 0.48
DBA/2J f 6978.0 3464.0   8 1225.0 0.496 2334.0, 12205.0 0.61
DBA/2J m 6892.0 4935.0   8 1745.0 0.716 1989.0, 15219.0 0.66
FVB/NJ f 14261.0 2042.0   8 722.0 0.143 11563.0, 16726.0 2.6
FVB/NJ m 10007.0 4269.0   8 1509.0 0.427 3426.0, 15442.0 1.7
SJL/J f 3291.0 1883.0   8 666.0 0.572 268.0, 5787.0 -0.4
SJL/J m 3836.0 2437.0   8 862.0 0.635 1006.0, 8331.0 -0.36
SPRET/EiJ f 2761.0 938.0   7 354.0 0.34 1693.0, 4004.0 -0.55
SPRET/EiJ m 2056.0 783.0   6 320.0 0.381 1051.0, 2969.0 -0.96
Tac:SW f 4928.0 1849.0   8 654.0 0.375 2068.0, 8050.0 0.05
Tac:SW m 4170.0 3510.0   8 1241.0 0.842 1327.0, 12436.0 -0.25


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 1520.875 934.1732 3362.9117 0.0
129S1/SvImJ m 2016.625 934.1732 3858.6617 174.5883
129S6/SvEvTac f 558.375 934.1732 2400.4117 0.0
129S6/SvEvTac m 822.75 934.1732 2664.7867 0.0
129X1/SvJ f 966.5 934.1732 2808.5367 0.0
129X1/SvJ m 1281.25 934.1732 3123.2867 0.0
A/J f 1895.5 934.1732 3737.5367 53.4633
A/J m 2206.75 934.1732 4048.7867 364.7133
BALB/cByJ f 6230.75 934.1732 8072.7867 4388.7133
BALB/cByJ m 7461.875 934.1732 9303.9117 5619.8383
BALB/cJ f 5343.4286 998.6731 7312.6487 3374.2085
BALB/cJ m 5056.25 934.1732 6898.2867 3214.2133
C3H/HeJ f 1819.625 934.1732 3661.6617 0.0
C3H/HeJ m 5220.75 934.1732 7062.7867 3378.7133
C57BL/6J f 8517.2857 998.6731 10486.5058 6548.0656
C57BL/6J m 6123.875 934.1732 7965.9117 4281.8383
CAST/EiJ f 7810.5 934.1732 9652.5367 5968.4633
CAST/EiJ m 10385.5 1321.1203 12990.5333 7780.4667
Crl:CD-1(ICR) f 4485.25 934.1732 6327.2867 2643.2133
Crl:CD-1(ICR) m 6370.875 934.1732 8212.9117 4528.8383
DBA/2J f 6978.0 934.1732 8820.0367 5135.9633
DBA/2J m 6891.5 934.1732 8733.5367 5049.4633
FVB/NJ f 14261.25 934.1732 16103.2867 12419.2133
FVB/NJ m 10007.125 934.1732 11849.1617 8165.0883
SJL/J f 3291.125 934.1732 5133.1617 1449.0883
SJL/J m 3836.25 934.1732 5678.2867 1994.2133
SPRET/EiJ f 2761.4286 998.6731 4730.6487 792.2085
SPRET/EiJ m 2056.5 1078.6902 4183.5008 0.0
Tac:SW f 4927.75 934.1732 6769.7867 3085.7133
Tac:SW m 4170.375 934.1732 6012.4117 2328.3383


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 1768.75 660.5602 3071.2667 466.2333
129S6/SvEvTac both 690.5625 660.5602 1993.0792 0.0
129X1/SvJ both 1123.875 660.5602 2426.3917 0.0
A/J both 2051.125 660.5602 3353.6417 748.6083
BALB/cByJ both 6846.3125 660.5602 8148.8292 5543.7958
BALB/cJ both 5199.8393 683.7447 6548.0721 3851.6065
C3H/HeJ both 3520.1875 660.5602 4822.7042 2217.6708
C57BL/6J both 7320.5804 683.7447 8668.8132 5972.3475
CAST/EiJ both 9098.0 809.0177 10693.2506 7502.7494
Crl:CD-1(ICR) both 5428.0625 660.5602 6730.5792 4125.5458
DBA/2J both 6934.75 660.5602 8237.2667 5632.2333
FVB/NJ both 12134.1875 660.5602 13436.7042 10831.6708
SJL/J both 3563.6875 660.5602 4866.2042 2261.1708
SPRET/EiJ both 2408.9643 735.0035 3858.271 959.6575
Tac:SW both 4549.0625 660.5602 5851.5792 3246.5458




  GWAS USING LINEAR MIXED MODELS