Project measure / variable:   Thomsen1   activ_cocaine1_56


  STRAIN COMPARISON PLOT
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Thomsen1 - total activity, test 1, 3h test dose 56 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means5148   n 5121   n
Median of the strain means5162   n 4559   n
SD of the strain means± 3806 ± 2820
Coefficient of variation (CV)0.739 0.551
Min–max range of strain means494   –   13548   n 638   –   9913   n
Mean sample size per strain8.0   mice 7.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2236086.055 2236086.055 0.2614 0.6097
strain 14 2133654879.7603 152403919.9829 17.8183 < 0.0001
sex:strain 14 269711314.0069 19265093.8576 2.2524 0.0072
Residuals 204 1744861792.6607 8553244.0817


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 1458.0 546.0   8 193.0 0.375 945.0, 2374.0 -0.97
129S1/SvImJ m 3155.0 3610.0   8 1276.0 1.14 1383.0, 12018.0 -0.7
129S6/SvEvTac f 494.0 216.0   8 76.4 0.438 213.0, 854.0 -1.22
129S6/SvEvTac m 638.0 229.0   8 80.8 0.358 310.0, 1093.0 -1.59
129X1/SvJ f 1216.0 550.0   8 194.0 0.452 417.0, 2029.0 -1.03
129X1/SvJ m 3678.0 4034.0   8 1426.0 1.1 836.0, 11003.0 -0.51
A/J f 1640.0 970.0   8 343.0 0.591 674.0, 3219.0 -0.92
A/J m 1527.0 771.0   8 273.0 0.505 718.0, 2802.0 -1.27
BALB/cByJ f 7486.0 2299.0   8 813.0 0.307 4441.0, 10480.0 0.61
BALB/cByJ m 6756.0 1022.0   8 361.0 0.151 4677.0, 8098.0 0.58
BALB/cJ f 5206.0 1088.0   8 385.0 0.209 3615.0, 6766.0 0.02
BALB/cJ m 4359.0 2683.0   8 948.0 0.615 1463.0, 10214.0 -0.27
C3H/HeJ f 2153.0 1483.0   8 524.0 0.689 557.0, 4650.0 -0.79
C3H/HeJ m 4559.0 1594.0   8 563.0 0.35 1028.0, 6363.0 -0.2
C57BL/6J f 9352.0 3743.0   8 1323.0 0.4 5404.0, 17302.0 1.1
C57BL/6J m 9454.0 3899.0   8 1379.0 0.412 5342.0, 14767.0 1.54
CAST/EiJ f 9829.0 4393.0   8 1553.0 0.447 4843.0, 18156.0 1.23
CAST/EiJ m 9913.0 2900.0   4 1450.0 0.293 5928.0, 12827.0 1.7
Crl:CD-1(ICR) f 6744.0 5343.0   8 1889.0 0.792 1707.0, 18231.0 0.42
Crl:CD-1(ICR) m 8940.0 5872.0   8 2076.0 0.657 727.0, 19176.0 1.35
DBA/2J f 3877.0 1262.0   8 446.0 0.326 2080.0, 5773.0 -0.33
DBA/2J m 5165.0 3447.0   8 1219.0 0.667 2174.0, 11793.0 0.02
FVB/NJ f 13548.0 5656.0   8 2000.0 0.418 5704.0, 24592.0 2.21
FVB/NJ m 7222.0 3202.0   8 1132.0 0.443 2316.0, 11145.0 0.75
SJL/J f 5162.0 2302.0   8 814.0 0.446 1080.0, 8834.0 0.0
SJL/J m 3954.0 2339.0   8 827.0 0.592 625.0, 7512.0 -0.41
SPRET/EiJ f 2267.0 973.0   7 368.0 0.429 779.0, 3608.0 -0.76
SPRET/EiJ m 2545.0 1279.0   7 483.0 0.503 359.0, 4483.0 -0.91
Tac:SW f 6787.0 1969.0   8 696.0 0.29 4084.0, 9082.0 0.43
Tac:SW m 4948.0 3250.0   8 1149.0 0.657 1589.0, 11010.0 -0.06


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 1457.5 1033.9998 3496.1969 0.0
129S1/SvImJ m 3155.375 1033.9998 5194.0719 1116.6781
129S6/SvEvTac f 494.0 1033.9998 2532.6969 0.0
129S6/SvEvTac m 637.75 1033.9998 2676.4469 0.0
129X1/SvJ f 1215.5 1033.9998 3254.1969 0.0
129X1/SvJ m 3677.625 1033.9998 5716.3219 1638.9281
A/J f 1639.5 1033.9998 3678.1969 0.0
A/J m 1527.125 1033.9998 3565.8219 0.0
BALB/cByJ f 7485.75 1033.9998 9524.4469 5447.0531
BALB/cByJ m 6755.625 1033.9998 8794.3219 4716.9281
BALB/cJ f 5206.5 1033.9998 7245.1969 3167.8031
BALB/cJ m 4359.0 1033.9998 6397.6969 2320.3031
C3H/HeJ f 2153.125 1033.9998 4191.8219 114.4281
C3H/HeJ m 4558.625 1033.9998 6597.3219 2519.9281
C57BL/6J f 9351.875 1033.9998 11390.5719 7313.1781
C57BL/6J m 9454.125 1033.9998 11492.8219 7415.4281
CAST/EiJ f 9829.0 1033.9998 11867.6969 7790.3031
CAST/EiJ m 9912.75 1462.2965 12795.9028 7029.5972
Crl:CD-1(ICR) f 6744.125 1033.9998 8782.8219 4705.4281
Crl:CD-1(ICR) m 8940.375 1033.9998 10979.0719 6901.6781
DBA/2J f 3876.625 1033.9998 5915.3219 1837.9281
DBA/2J m 5164.75 1033.9998 7203.4469 3126.0531
FVB/NJ f 13547.5 1033.9998 15586.1969 11508.8031
FVB/NJ m 7221.5 1033.9998 9260.1969 5182.8031
SJL/J f 5162.375 1033.9998 7201.0719 3123.6781
SJL/J m 3953.625 1033.9998 5992.3219 1914.9281
SPRET/EiJ f 2266.8571 1105.3922 4446.3158 87.3985
SPRET/EiJ m 2545.2857 1105.3922 4724.7444 365.8271
Tac:SW f 6787.375 1033.9998 8826.0719 4748.6781
Tac:SW m 4948.375 1033.9998 6987.0719 2909.6781


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 2306.4375 731.1482 3748.0139 864.8611
129S6/SvEvTac both 565.875 731.1482 2007.4514 0.0
129X1/SvJ both 2446.5625 731.1482 3888.1389 1004.9861
A/J both 1583.3125 731.1482 3024.8889 141.7361
BALB/cByJ both 7120.6875 731.1482 8562.2639 5679.1111
BALB/cJ both 4782.75 731.1482 6224.3264 3341.1736
C3H/HeJ both 3355.875 731.1482 4797.4514 1914.2986
C57BL/6J both 9403.0 731.1482 10844.5764 7961.4236
CAST/EiJ both 9870.875 895.4701 11636.4383 8105.3117
Crl:CD-1(ICR) both 7842.25 731.1482 9283.8264 6400.6736
DBA/2J both 4520.6875 731.1482 5962.2639 3079.1111
FVB/NJ both 10384.5 731.1482 11826.0764 8942.9236
SJL/J both 4558.0 731.1482 5999.5764 3116.4236
SPRET/EiJ both 2406.0714 781.6304 3947.1814 864.9614
Tac:SW both 5867.875 731.1482 7309.4514 4426.2986




  GWAS USING LINEAR MIXED MODELS