Project measure / variable:   Thomsen1   activ_cocaine1_10

ID, description, units MPD:40703   activ_cocaine1_10   total activity, test 1, 3h test   [n]  dose 10 mg/kg  
cocaine study
Data set, strains Thomsen1   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen1 - total activity, test 1, 3h test dose 10 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means2924   n 2713   n
Median of the strain means1440   n 2007   n
SD of the strain means± 2676 ± 2440
Coefficient of variation (CV)0.915 0.899
Min–max range of strain means308   –   7818   n 301   –   8442   n
Mean sample size per strain8.0   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4990844.1377 4990844.1377 1.7318 0.1897
strain 14 1347464038.8947 96247431.3496 33.3982 < 0.0001
sex:strain 14 88867065.1955 6347647.514 2.2027 0.0088
Residuals 203 585008372.7679 2881814.6442


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 603.0 263.0   8 93.1 0.436 287.0, 1009.0 -0.87
129S1/SvImJ m 759.0 373.0   8 132.0 0.492 257.0, 1334.0 -0.8
129S6/SvEvTac f 360.0 191.0   8 67.5 0.53 81.0, 676.0 -0.96
129S6/SvEvTac m 509.0 102.0   8 36.2 0.201 372.0, 662.0 -0.9
129X1/SvJ f 308.0 161.0   8 56.9 0.522 149.0, 661.0 -0.98
129X1/SvJ m 301.0 100.0   8 35.5 0.334 184.0, 475.0 -0.99
A/J f 812.0 426.0   8 151.0 0.525 357.0, 1780.0 -0.79
A/J m 1199.0 683.0   8 241.0 0.57 629.0, 2334.0 -0.62
BALB/cByJ f 4446.0 1577.0   8 558.0 0.355 2463.0, 6734.0 0.57
BALB/cByJ m 6514.0 845.0   8 299.0 0.13 5573.0, 8089.0 1.56
BALB/cJ f 7113.0 1935.0   8 684.0 0.272 3424.0, 9741.0 1.57
BALB/cJ m 4278.0 3192.0   8 1129.0 0.746 1003.0, 10342.0 0.64
C3H/HeJ f 1440.0 681.0   8 241.0 0.473 687.0, 2338.0 -0.55
C3H/HeJ m 2007.0 1233.0   7 466.0 0.614 589.0, 3941.0 -0.29
C57BL/6J f 6564.0 4165.0   8 1473.0 0.635 4003.0, 16435.0 1.36
C57BL/6J m 3676.0 3480.0   8 1230.0 0.947 937.0, 10540.0 0.39
CAST/EiJ f 5245.0 2269.0   8 802.0 0.433 987.0, 8704.0 0.87
CAST/EiJ m 5139.0 2076.0   4 1038.0 0.404 3059.0, 8017.0 0.99
Crl:CD-1(ICR) f 2561.0 2193.0   8 775.0 0.857 459.0, 5630.0 -0.14
Crl:CD-1(ICR) m 2265.0 2258.0   8 798.0 0.997 691.0, 7414.0 -0.18
DBA/2J f 948.0 314.0   8 111.0 0.332 571.0, 1362.0 -0.74
DBA/2J m 1181.0 485.0   8 172.0 0.411 782.0, 2227.0 -0.63
FVB/NJ f 7818.0 2143.0   8 758.0 0.274 5566.0, 11065.0 1.83
FVB/NJ m 8442.0 2436.0   8 861.0 0.289 5120.0, 12684.0 2.35
SJL/J f 1268.0 943.0   8 333.0 0.744 527.0, 2832.0 -0.62
SJL/J m 735.0 388.0   8 137.0 0.528 280.0, 1285.0 -0.81
SPRET/EiJ f 691.0 411.0   7 155.0 0.595 277.0, 1397.0 -0.83
SPRET/EiJ m 954.0 595.0   7 225.0 0.624 352.0, 1814.0 -0.72
Tac:SW f 3676.0 1395.0   8 493.0 0.379 2368.0, 6599.0 0.28
Tac:SW m 2737.0 1752.0   8 619.0 0.64 603.0, 5731.0 0.01


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 603.375 600.189 1786.779 0.0
129S1/SvImJ m 759.125 600.189 1942.529 0.0
129S6/SvEvTac f 360.25 600.189 1543.654 0.0
129S6/SvEvTac m 508.75 600.189 1692.154 0.0
129X1/SvJ f 308.375 600.189 1491.779 0.0
129X1/SvJ m 300.625 600.189 1484.029 0.0
A/J f 811.75 600.189 1995.154 0.0
A/J m 1199.0 600.189 2382.404 15.596
BALB/cByJ f 4445.5 600.189 5628.904 3262.096
BALB/cByJ m 6514.375 600.189 7697.779 5330.971
BALB/cJ f 7112.875 600.189 8296.279 5929.471
BALB/cJ m 4277.75 600.189 5461.154 3094.346
C3H/HeJ f 1440.25 600.189 2623.654 256.846
C3H/HeJ m 2007.2857 641.629 3272.3978 742.1737
C57BL/6J f 6563.5 600.189 7746.904 5380.096
C57BL/6J m 3675.5 600.189 4858.904 2492.096
CAST/EiJ f 5245.125 600.189 6428.529 4061.721
CAST/EiJ m 5139.0 848.7954 6812.5859 3465.4141
Crl:CD-1(ICR) f 2560.625 600.189 3744.029 1377.221
Crl:CD-1(ICR) m 2265.0 600.189 3448.404 1081.596
DBA/2J f 947.625 600.189 2131.029 0.0
DBA/2J m 1180.625 600.189 2364.029 0.0
FVB/NJ f 7818.125 600.189 9001.529 6634.721
FVB/NJ m 8441.875 600.189 9625.279 7258.471
SJL/J f 1267.875 600.189 2451.279 84.471
SJL/J m 734.875 600.189 1918.279 0.0
SPRET/EiJ f 690.5714 641.629 1955.6835 0.0
SPRET/EiJ m 954.0 641.629 2219.112 0.0
Tac:SW f 3676.5 600.189 4859.904 2493.096
Tac:SW m 2736.875 600.189 3920.279 1553.471


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 681.25 424.3977 1518.043 0.0
129S6/SvEvTac both 434.5 424.3977 1271.293 0.0
129X1/SvJ both 304.5 424.3977 1141.293 0.0
A/J both 1005.375 424.3977 1842.168 168.582
BALB/cByJ both 5479.9375 424.3977 6316.7305 4643.1445
BALB/cJ both 5695.3125 424.3977 6532.1055 4858.5195
C3H/HeJ both 1723.7679 439.2934 2589.9309 857.6049
C57BL/6J both 5119.5 424.3977 5956.293 4282.707
CAST/EiJ both 5192.0625 519.7789 6216.9204 4167.2046
Crl:CD-1(ICR) both 2412.8125 424.3977 3249.6055 1576.0195
DBA/2J both 1064.125 424.3977 1900.918 227.332
FVB/NJ both 8130.0 424.3977 8966.793 7293.207
SJL/J both 1001.375 424.3977 1838.168 164.582
SPRET/EiJ both 822.2857 453.7002 1716.855 0.0
Tac:SW both 3206.6875 424.3977 4043.4805 2369.8945




  GWAS USING LINEAR MIXED MODELS