Project measure / variable:   Wiltshire2   norfluoxetine

ID, description, units MPD:38008   norfluoxetine   drug and metabolite concentration   [ng/mL]  norfluoxetine  
fluoxetine study
Data set, strains Wiltshire2   inbred   30 strains     sex: m     age: 10-11wks
Procedure drug and metabolite quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Wiltshire2 - drug and metabolite concentration norfluoxetine



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested30 strains
Mean of the strain means1098   ng/mL
Median of the strain means1122   ng/mL
SD of the strain means± 263
Coefficient of variation (CV)0.240
Min–max range of strain means579   –   1612   ng/mL
Mean sample size per strain11.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 29 21601898.1137 744893.0384 6.2745 < 0.0001
Residuals 309 36683681.8826 118717.4171


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 1080.0 163.0   13 45.2 0.151 788.0, 1370.0 -0.07
A/J m 1223.0 186.0   15 48.0 0.152 889.0, 1630.0 0.48
AKR/J m 1119.0 148.0   9 49.3 0.132 993.0, 1450.0 0.08
BALB/cJ m 931.0 173.0   12 49.9 0.186 696.0, 1230.0 -0.63
BTBR T+ Itpr3tf/J m 1238.0 274.0   12 79.2 0.222 938.0, 1940.0 0.53
BUB/BnJ m 1392.0 444.0   9 148.0 0.319 875.0, 2460.0 1.12
C3H/HeJ m 950.0 252.0   15 65.1 0.266 279.0, 1260.0 -0.56
C57BL/6J m 1509.0 493.0   7 186.0 0.327 983.0, 2490.0 1.57
C57BLKS/J m 1195.0 165.0   12 47.6 0.138 1040.0, 1550.0 0.37
C57BR/cdJ m 1260.0 486.0   10 154.0 0.386 853.0, 2510.0 0.62
C58/J m 1336.0 318.0   9 106.0 0.238 1030.0, 2040.0 0.91
CBA/J m 1093.0 361.0   11 109.0 0.33 448.0, 1730.0 -0.02
CE/J m 1401.0 256.0   12 74.0 0.183 994.0, 1910.0 1.15
DBA/2J m 1027.0 226.0   16 56.4 0.22 681.0, 1370.0 -0.27
FVB/NJ m 798.0 360.0   9 120.0 0.451 27.5, 1130.0 -1.14
I/LnJ m 1438.0 370.0   8 131.0 0.258 726.0, 1980.0 1.3
LG/J m 1612.0 405.0   9 135.0 0.251 1220.0, 2410.0 1.96
LP/J m 783.0 321.0   19 73.7 0.41 285.0, 1240.0 -1.2
MA/MyJ m 1314.0 360.0   9 120.0 0.274 795.0, 1930.0 0.82
MRL/MpJ m 1047.0 429.0   9 143.0 0.41 673.0, 2100.0 -0.19
NOD/ShiLtJ m 912.0 279.0   12 80.6 0.306 203.0, 1270.0 -0.71
NOR/LtJ m 747.0 253.0   15 65.2 0.338 185.0, 1060.0 -1.33
NZB/BlNJ m 1156.0 281.0   12 81.2 0.243 841.0, 1720.0 0.22
NZW/LacJ m 763.0 144.0   9 48.0 0.189 546.0, 1010.0 -1.27
P/J m 1268.0 818.0   11 247.0 0.646 189.0, 2320.0 0.65
PL/J m 826.0 388.0   12 112.0 0.469 29.3, 1180.0 -1.03
RIIIS/J m 579.0 89.5   12 25.8 0.155 429.0, 726.0 -1.97
SJL/J m 1124.0 215.0   11 64.8 0.191 877.0, 1440.0 0.1
SM/J m 1160.0 725.0   8 256.0 0.625 83.0, 2030.0 0.24
SWR/J m 644.0 376.0   12 109.0 0.584 10.0, 1030.0 -1.72


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 1079.7692 95.5621 1267.8039 891.7345
A/J m 1222.6 88.9634 1397.6508 1047.5492
AKR/J m 1119.2222 114.8513 1345.2118 893.2326
BALB/cJ m 930.75 99.4642 1126.4627 735.0373
BTBR T+ Itpr3tf/J m 1238.5 99.4642 1434.2127 1042.7873
BUB/BnJ m 1391.6667 114.8513 1617.6563 1165.6771
C3H/HeJ m 949.5333 88.9634 1124.5841 774.4826
C57BL/6J m 1509.0 130.2291 1765.2481 1252.7519
C57BLKS/J m 1195.0 99.4642 1390.7127 999.2873
C57BR/cdJ m 1260.4 108.9575 1474.7925 1046.0075
C58/J m 1335.5556 114.8513 1561.5451 1109.566
CBA/J m 1093.2727 103.8869 1297.688 888.8575
CE/J m 1401.1667 99.4642 1596.8794 1205.4539
DBA/2J m 1026.6875 86.1385 1196.1797 857.1953
FVB/NJ m 798.2778 114.8513 1024.2674 572.2882
I/LnJ m 1438.25 121.8182 1677.9482 1198.5518
LG/J m 1612.2222 114.8513 1838.2118 1386.2326
LP/J m 783.3684 79.0461 938.9051 627.8317
MA/MyJ m 1314.3333 114.8513 1540.3229 1088.3437
MRL/MpJ m 1047.4444 114.8513 1273.434 821.4549
NOD/ShiLtJ m 912.0 99.4642 1107.7127 716.2873
NOR/LtJ m 746.9333 88.9634 921.9841 571.8826
NZB/BlNJ m 1156.3333 99.4642 1352.0461 960.6206
NZW/LacJ m 762.8889 114.8513 988.8785 536.8993
P/J m 1267.5455 103.8869 1471.9607 1063.1302
PL/J m 825.8583 99.4642 1021.5711 630.1456
RIIIS/J m 578.5833 99.4642 774.2961 382.8706
SJL/J m 1124.4545 103.8869 1328.8698 920.0393
SM/J m 1160.225 121.8182 1399.9232 920.5268
SWR/J m 643.7917 99.4642 839.5044 448.0789




  GWAS USING LINEAR MIXED MODELS