Project measure / variable:   Wiltshire2   fluoxetine

ID, description, units MPD:38007   fluoxetine   drug and metabolite concentration   [ng/mL]  fluoxetine  
fluoxetine study
Data set, strains Wiltshire2   inbred   30 strains     sex: m     age: 10-11wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Wiltshire2 - drug and metabolite concentration fluoxetine



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested30 strains
Mean of the strain means1052   ng/mL
Median of the strain means988   ng/mL
SD of the strain means± 371
Coefficient of variation (CV)0.353
Min–max range of strain means470   –   1906   ng/mL
Mean sample size per strain11.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 29 42612665.2957 1469402.2516 7.3127 < 0.0001
Residuals 309 62090143.7036 200938.9764


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 1153.0 209.0   13 58.0 0.181 750.0, 1450.0 0.27
A/J m 938.0 185.0   15 47.7 0.197 599.0, 1240.0 -0.31
AKR/J m 988.0 160.0   9 53.4 0.162 781.0, 1240.0 -0.17
BALB/cJ m 800.0 140.0   12 40.5 0.175 609.0, 1070.0 -0.68
BTBR T+ Itpr3tf/J m 912.0 178.0   12 51.4 0.195 625.0, 1230.0 -0.38
BUB/BnJ m 1397.0 430.0   9 143.0 0.308 932.0, 2380.0 0.93
C3H/HeJ m 763.0 257.0   15 66.4 0.337 234.0, 1140.0 -0.78
C57BL/6J m 1328.0 584.0   7 221.0 0.44 772.0, 2410.0 0.74
C57BLKS/J m 1244.0 333.0   12 96.1 0.268 861.0, 2060.0 0.52
C57BR/cdJ m 989.0 478.0   10 151.0 0.483 586.0, 2130.0 -0.17
C58/J m 987.0 349.0   9 116.0 0.354 639.0, 1630.0 -0.18
CBA/J m 1104.0 359.0   11 108.0 0.325 654.0, 1780.0 0.14
CE/J m 1084.0 253.0   12 73.2 0.234 678.0, 1500.0 0.09
DBA/2J m 956.0 383.0   16 95.7 0.4 424.0, 1800.0 -0.26
FVB/NJ m 595.0 244.0   9 81.4 0.41 45.7, 867.0 -1.23
I/LnJ m 1606.0 900.0   8 318.0 0.56 802.0, 3680.0 1.49
LG/J m 1540.0 351.0   9 117.0 0.228 1110.0, 2280.0 1.31
LP/J m 720.0 293.0   19 67.3 0.408 263.0, 1350.0 -0.89
MA/MyJ m 1906.0 672.0   9 224.0 0.353 1140.0, 3200.0 2.3
MRL/MpJ m 1067.0 551.0   9 184.0 0.516 632.0, 2470.0 0.04
NOD/ShiLtJ m 776.0 284.0   12 81.9 0.366 244.0, 1290.0 -0.74
NOR/LtJ m 483.0 187.0   15 48.4 0.388 107.0, 824.0 -1.53
NZB/BlNJ m 1311.0 494.0   12 143.0 0.377 754.0, 2450.0 0.7
NZW/LacJ m 591.0 200.0   9 66.6 0.338 320.0, 857.0 -1.24
P/J m 1886.0 1351.0   11 407.0 0.716 260.0, 4260.0 2.25
PL/J m 757.0 337.0   12 97.2 0.445 55.2, 1110.0 -0.79
RIIIS/J m 470.0 126.0   12 36.5 0.269 297.0, 755.0 -1.57
SJL/J m 1275.0 358.0   11 108.0 0.281 916.0, 2090.0 0.6
SM/J m 1187.0 906.0   8 320.0 0.763 94.6, 2310.0 0.36
SWR/J m 749.0 383.0   12 111.0 0.512 24.7, 1180.0 -0.82


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 1152.9231 124.3256 1397.5549 908.2913
A/J m 937.8667 115.7408 1165.6065 710.1269
AKR/J m 988.1111 149.4207 1282.1219 694.1003
BALB/cJ m 800.1667 129.4021 1054.7875 545.5458
BTBR T+ Itpr3tf/J m 912.0833 129.4021 1166.7042 657.4625
BUB/BnJ m 1396.8889 149.4207 1690.8997 1102.8781
C3H/HeJ m 763.0667 115.7408 990.8065 535.3269
C57BL/6J m 1327.5714 169.4272 1660.9484 994.1945
C57BLKS/J m 1243.5 129.4021 1498.1208 988.8792
C57BR/cdJ m 988.9 141.7529 1267.8231 709.9769
C58/J m 987.2222 149.4207 1281.233 693.2114
CBA/J m 1103.9091 135.1561 1369.8519 837.9663
CE/J m 1084.4167 129.4021 1339.0375 829.7958
DBA/2J m 956.5 112.0655 1177.0081 735.9919
FVB/NJ m 595.1889 149.4207 889.1997 301.1781
I/LnJ m 1606.5 158.4846 1918.3456 1294.6544
LG/J m 1540.0 149.4207 1834.0108 1245.9892
LP/J m 719.6316 102.8384 921.9837 517.2795
MA/MyJ m 1905.5556 149.4207 2199.5664 1611.5447
MRL/MpJ m 1066.6667 149.4207 1360.6775 772.6559
NOD/ShiLtJ m 775.5 129.4021 1030.1208 520.8792
NOR/LtJ m 483.3333 115.7408 711.0731 255.5935
NZB/BlNJ m 1311.0833 129.4021 1565.7042 1056.4625
NZW/LacJ m 591.4444 149.4207 885.4553 297.4336
P/J m 1885.5455 135.1561 2151.4882 1619.6027
PL/J m 757.35 129.4021 1011.9708 502.7292
RIIIS/J m 470.25 129.4021 724.8708 215.6292
SJL/J m 1274.8182 135.1561 1540.761 1008.8754
SM/J m 1186.95 158.4846 1498.7956 875.1044
SWR/J m 749.3083 129.4021 1003.9292 494.6875




  GWAS USING LINEAR MIXED MODELS