MPD: Project measure / variable: Wiltshire2 OFT_dist

Project measure / variable: Wiltshire2 OFT_dist_fluox

ID, description, units	MPD:38006 OFT_dist_fluox OFT distance traveled, 10 min test [cm] fluoxetine fluoxetine study
Data set, strains	Wiltshire2 inbred 30 strains sex: m age: 10-11wks
Procedure	open field test
Ontology mappings	MP:0001362 abnormal anxiety-related response MP:0001392 abnormal locomotor behavior MP:0009745 abnormal behavioral response to xenobiotic MP:0013189 abnormal exploration in a new environment VT:0001392 locomotor behavior trait VT:0010471 exploratory behavior trait VT:0010487 response to xenobiotic stimulus trait VT:0010716 anxiety-related behavior trait

STRAIN COMPARISON PLOT

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Visualization Options Least squares means Alphabetical order Strains on X-axis Individual points

Wiltshire2 - OFT distance traveled, 10 min test fluoxetine

MEASURE SUMMARY

Measure Summary	Male
Number of strains tested	30 strains
Mean of the strain means	1703 cm
Median of the strain means	1644 cm
SD of the strain means	± 804
Coefficient of variation (CV)	0.472
Min–max range of strain means	294 – 3512 cm
Mean sample size per strain	11.2 mice

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p value (Pr>F)
strain	29	211406575.5395	7289881.9152	14.7745	< 0.0001
Residuals	311	153450891.4775	493411.2266

Q-Q normality assessment based on residuals

STRAIN MEANS (UNADJUSTED)

Strain	Sex	Mean	SD	N mice	SEM	CV	Min, Max	Z score
129S1/SvImJ	m	360.0	303.0	12	87.6	0.842	24.4, 778.0	-1.67
A/J	m	294.0	296.0	15	76.5	1.01	36.9, 1079.0	-1.75
AKR/J	m	1824.0	358.0	9	119.0	0.196	1314.0, 2397.0	0.15
BALB/cJ	m	1019.0	702.0	11	212.0	0.689	63.6, 1921.0	-0.85
BTBR T⁺ Itpr3^tf/J	m	2131.0	822.0	12	237.0	0.386	685.0, 3551.0	0.53
BUB/BnJ	m	2393.0	818.0	9	273.0	0.342	1679.0, 4375.0	0.86
C3H/HeJ	m	1080.0	166.0	15	42.8	0.154	840.0, 1394.0	-0.77
C57BL/6J	m	1175.0	317.0	9	106.0	0.27	698.0, 1564.0	-0.66
C57BLKS/J	m	1005.0	661.0	12	191.0	0.658	355.0, 2643.0	-0.87
C57BR/cdJ	m	2712.0	716.0	12	207.0	0.264	1642.0, 3788.0	1.26
C58/J	m	2973.0	1752.0	9	584.0	0.589	1020.0, 6115.0	1.58
CBA/J	m	1507.0	374.0	13	104.0	0.249	796.0, 2203.0	-0.24
CE/J	m	1518.0	487.0	12	140.0	0.32	976.0, 2485.0	-0.23
DBA/2J	m	1824.0	1053.0	17	255.0	0.577	286.0, 4405.0	0.15
FVB/NJ	m	1870.0	322.0	9	107.0	0.172	1496.0, 2403.0	0.21
I/LnJ	m	2040.0	805.0	8	285.0	0.395	153.0, 2667.0	0.42
LG/J	m	1271.0	190.0	9	63.3	0.149	1002.0, 1631.0	-0.54
LP/J	m	612.0	396.0	19	90.8	0.647	17.0, 1368.0	-1.36
MA/MyJ	m	3512.0	1185.0	9	395.0	0.338	2024.0, 5847.0	2.25
MRL/MpJ	m	1396.0	388.0	8	137.0	0.278	664.0, 1891.0	-0.38
NOD/ShiLtJ	m	2415.0	696.0	11	210.0	0.288	1017.0, 3866.0	0.89
NOR/LtJ	m	2282.0	354.0	14	94.6	0.155	1662.0, 2780.0	0.72
NZB/BlNJ	m	942.0	408.0	11	123.0	0.433	37.8, 1564.0	-0.95
NZW/LacJ	m	1351.0	486.0	9	162.0	0.36	479.0, 2244.0	-0.44
P/J	m	2446.0	997.0	11	301.0	0.408	1375.0, 4911.0	0.92
PL/J	m	1770.0	394.0	12	114.0	0.223	1406.0, 2766.0	0.08
RIIIS/J	m	1825.0	294.0	12	84.8	0.161	1394.0, 2317.0	0.15
SJL/J	m	853.0	261.0	11	78.7	0.306	530.0, 1466.0	-1.06
SM/J	m	3181.0	1923.0	9	641.0	0.605	1415.0, 6574.0	1.84
SWR/J	m	1499.0	234.0	12	67.5	0.156	1234.0, 1939.0	-0.25

LEAST SQUARES MEANS (MODEL-ADJUSTED)

Strain	Sex	Mean	SEM	UpperCL	LowerCL
129S1/SvImJ	m	360.1083	202.7748	759.0922	0.0
A/J	m	293.5	181.3673	650.362	0.0
AKR/J	m	1824.1111	234.1441	2284.818	1363.4042
BALB/cJ	m	1018.5818	211.7913	1435.3069	601.8567
BTBR T⁺ Itpr3^tf/J	m	2131.0833	202.7748	2530.0672	1732.0994
BUB/BnJ	m	2392.7778	234.1441	2853.4847	1932.0709
C3H/HeJ	m	1079.7333	181.3673	1436.5954	722.8713
C57BL/6J	m	1174.7778	234.1441	1635.4847	714.0709
C57BLKS/J	m	1004.75	202.7748	1403.7339	605.7661
C57BR/cdJ	m	2712.5	202.7748	3111.4839	2313.5161
C58/J	m	2972.8889	234.1441	3433.5958	2512.182
CBA/J	m	1506.5385	194.8197	1889.8698	1123.2071
CE/J	m	1518.3333	202.7748	1917.3172	1119.3494
DBA/2J	m	1824.2941	170.3649	2159.5076	1489.0806
FVB/NJ	m	1869.7778	234.1441	2330.4847	1409.0709
I/LnJ	m	2040.375	248.3473	2529.0285	1551.7215
LG/J	m	1271.0	234.1441	1731.7069	810.2931
LP/J	m	611.6158	161.149	928.696	294.5355
MA/MyJ	m	3511.8889	234.1441	3972.5958	3051.182
MRL/MpJ	m	1395.875	248.3473	1884.5285	907.2215
NOD/ShiLtJ	m	2415.3636	211.7913	2832.0887	1998.6385
NOR/LtJ	m	2282.1429	187.7329	2651.5302	1912.7555
NZB/BlNJ	m	942.2545	211.7913	1358.9796	525.5295
NZW/LacJ	m	1350.6667	234.1441	1811.3736	889.9597
P/J	m	2445.7273	211.7913	2862.4524	2029.0022
PL/J	m	1770.25	202.7748	2169.2339	1371.2661
RIIIS/J	m	1825.1667	202.7748	2224.1506	1426.1828
SJL/J	m	853.3636	211.7913	1270.0887	436.6385
SM/J	m	3180.7778	234.1441	3641.4847	2720.0709
SWR/J	m	1499.25	202.7748	1898.2339	1100.2661

INDIVIDUAL ANIMAL VALUES

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GWAS USING LINEAR MIXED MODELS