Project measure / variable:   Berndt2   penh_mch20

ID, description, units MPD:35164   penh_mch20   enhanced pause    20 MCh  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - enhanced pause 20 MCh



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means5.11   None 6.44   None
Median of the strain means4.51   None 5.41   None
SD of the strain means± 2.76 ± 3.97
Coefficient of variation (CV)0.541 0.617
Min–max range of strain means1.65   –   11.0   None 1.44   –   14.7   None
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 184.6902 184.6902 19.5224 < 0.0001
strain 28 4134.7684 147.6703 15.6092 < 0.0001
sex:strain 28 1041.1829 37.1851 3.9306 < 0.0001
Residuals 412 3897.7033 9.4604


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 9.14 4.59   8 1.62 0.502 4.35, 17.9 1.46
129S1/SvImJ m 7.5 3.86   8 1.37 0.515 3.26, 12.9 0.27
A/J f 10.6 4.28   8 1.51 0.402 5.03, 16.6 1.99
A/J m 14.7 5.09   8 1.8 0.347 10.5, 25.7 2.08
AKR/J f 6.47 1.48   8 0.525 0.23 3.02, 7.88 0.49
AKR/J m 7.09 1.59   8 0.562 0.224 5.58, 10.6 0.16
BALB/cByJ f 4.51 3.04   8 1.07 0.674 1.36, 9.49 -0.22
BALB/cByJ m 1.57 0.464   8 0.164 0.295 0.94, 2.13 -1.23
BALB/cJ f 2.48 0.575   10 0.182 0.232 1.61, 3.15 -0.95
BALB/cJ m 3.68 0.941   10 0.297 0.255 2.57, 5.38 -0.69
BTBR T+ Itpr3tf/J f 11.0 3.44   8 1.22 0.314 4.74, 15.9 2.13
BTBR T+ Itpr3tf/J m 12.4 2.36   8 0.834 0.191 8.56, 15.4 1.5
BUB/BnJ f 10.1 8.37   7 3.16 0.826 2.12, 27.6 1.81
BUB/BnJ m 14.7 4.84   8 1.71 0.329 6.22, 23.5 2.08
C3H/HeJ f 2.82 1.13   8 0.398 0.399 1.44, 4.91 -0.83
C3H/HeJ m 4.39 2.72   8 0.963 0.621 0.94, 8.02 -0.52
C57BL/10J f 3.11 3.18   8 1.13 1.02 1.2, 10.8 -0.72
C57BL/10J m 9.46 4.69   7 1.77 0.496 4.49, 16.7 0.76
C57BL/6J f 5.19 2.72   7 1.03 0.524 2.29, 10.1 0.03
C57BL/6J m 5.86 2.05   13 0.569 0.35 2.7, 9.14 -0.15
C57BLKS/J f 3.6 2.44   11 0.737 0.679 0.6, 7.19 -0.54
C57BLKS/J m 5.41 1.04   8 0.366 0.191 3.88, 7.01 -0.26
C57BR/cdJ f 3.22 1.76   6 0.72 0.548 1.46, 6.08 -0.68
C57BR/cdJ m 4.26 3.33   8 1.18 0.781 0.48, 9.41 -0.55
C57L/J f 3.94 2.81   8 0.995 0.714 1.5, 10.0 -0.42
C57L/J m 8.32 2.31   8 0.815 0.277 4.8, 12.1 0.47
CBA/J f 5.45 1.05   8 0.372 0.193 4.14, 7.24 0.12
CBA/J m 5.21 0.573   8 0.202 0.11 4.39, 5.99 -0.31
CE/J f 2.53 1.39   8 0.493 0.55 1.1, 5.2 -0.93
CE/J m 1.44 0.682   9 0.227 0.474 0.54, 2.46 -1.26
DBA/1J f 5.93 3.61   10 1.14 0.609 1.44, 11.3 0.3
DBA/1J m 13.9 4.68   8 1.65 0.337 9.17, 20.2 1.88
DBA/2J f 5.07 2.48   8 0.878 0.49 1.85, 8.41 -0.01
DBA/2J m 5.75 2.84   10 0.898 0.494 1.17, 9.47 -0.17
FVB/NJ f 2.52 1.46   8 0.516 0.58 0.847, 5.54 -0.94
FVB/NJ m 5.36 1.5   7 0.568 0.28 4.1, 8.53 -0.27
I/LnJ f 8.19 7.21   7 2.72 0.88 3.27, 23.8 1.12
I/LnJ m 11.6 10.0   5 4.49 0.869 5.44, 29.2 1.3
KK/HlJ f 6.11 2.05   8 0.726 0.336 3.23, 8.55 0.36
KK/HlJ m 7.57 3.93   6 1.6 0.519 1.92, 13.7 0.28
LP/J f 1.65 0.659   8 0.233 0.399 0.71, 2.46 -1.25
LP/J m 1.77 1.51   8 0.534 0.856 0.59, 4.91 -1.18
NOD/ShiLtJ f 3.86 1.83   8 0.648 0.475 1.4, 6.76 -0.45
NOD/ShiLtJ m 3.26 1.76   8 0.623 0.542 1.71, 6.38 -0.8
NON/ShiLtJ f 2.9 1.52   8 0.539 0.526 1.49, 5.34 -0.8
NON/ShiLtJ m 2.1 0.579   8 0.205 0.276 1.3, 3.01 -1.09
NZW/LacJ f 9.3 4.73   8 1.67 0.509 4.65, 18.4 1.52
NZW/LacJ m 3.07 1.39   8 0.493 0.455 1.24, 5.21 -0.85
PL/J f 1.89 0.442   8 0.156 0.234 1.19, 2.31 -1.16
PL/J m 2.01 1.92   8 0.678 0.956 0.697, 6.6 -1.12
RIIIS/J f 5.36 1.81   8 0.639 0.337 2.8, 7.63 0.09
RIIIS/J m 4.05 3.58   8 1.27 0.884 1.05, 9.07 -0.6
SJL/J f 3.45 2.1   8 0.741 0.607 1.23, 7.74 -0.6
SJL/J m 4.87 1.54   8 0.545 0.317 2.11, 7.14 -0.4
SM/J f 5.45 1.44   8 0.508 0.264 3.28, 7.54 0.12
SM/J m 5.62 1.19   8 0.42 0.211 4.28, 7.56 -0.21
SWR/J f 2.23 1.28   8 0.453 0.575 1.09, 4.59 -1.04
SWR/J m 9.86 4.58   9 1.53 0.465 2.5, 17.2 0.86


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 9.1387 1.0875 11.2764 7.0011
129S1/SvImJ m 7.5 1.0875 9.6376 5.3624
A/J f 10.6238 1.0875 12.7614 8.4861
A/J m 14.6875 1.0875 16.8251 12.5499
AKR/J f 6.4675 1.0875 8.6051 4.3299
AKR/J m 7.0863 1.0875 9.2239 4.9486
BALB/cByJ f 4.5062 1.0875 6.6439 2.3686
BALB/cByJ m 1.5725 1.0875 3.7101 0.0
BALB/cJ f 2.476 0.9726 4.388 0.564
BALB/cJ m 3.684 0.9726 5.596 1.772
BTBR T+ Itpr3tf/J f 10.955 1.0875 13.0926 8.8174
BTBR T+ Itpr3tf/J m 12.355 1.0875 14.4926 10.2174
BUB/BnJ f 10.1271 1.1625 12.4124 7.8419
BUB/BnJ m 14.7275 1.0875 16.8651 12.5899
C3H/HeJ f 2.8187 1.0875 4.9564 0.6811
C3H/HeJ m 4.3875 1.0875 6.5251 2.2499
C57BL/10J f 3.1075 1.0875 5.2451 0.9699
C57BL/10J m 9.4614 1.1625 11.7467 7.1762
C57BL/6J f 5.19 1.1625 7.4752 2.9048
C57BL/6J m 5.8585 0.8531 7.5354 4.1816
C57BLKS/J f 3.6 0.9274 5.423 1.777
C57BLKS/J m 5.4113 1.0875 7.5489 3.2736
C57BR/cdJ f 3.2183 1.2557 5.6867 0.75
C57BR/cdJ m 4.265 1.0875 6.4026 2.1274
C57L/J f 3.9412 1.0875 6.0789 1.8036
C57L/J m 8.3212 1.0875 10.4589 6.1836
CBA/J f 5.4475 1.0875 7.5851 3.3099
CBA/J m 5.2075 1.0875 7.3451 3.0699
CE/J f 2.5325 1.0875 4.6701 0.3949
CE/J m 1.4378 1.0253 3.4532 0.0
DBA/1J f 5.934 0.9726 7.846 4.022
DBA/1J m 13.8713 1.0875 16.0089 11.7336
DBA/2J f 5.0712 1.0875 7.2089 2.9336
DBA/2J m 5.748 0.9726 7.66 3.836
FVB/NJ f 2.5159 1.0875 4.6535 0.3782
FVB/NJ m 5.3586 1.1625 7.6438 3.0733
I/LnJ f 8.1943 1.1625 10.4795 5.909
I/LnJ m 11.558 1.3755 14.2619 8.8541
KK/HlJ f 6.1087 1.0875 8.2464 3.9711
KK/HlJ m 7.5717 1.2557 10.04 5.1033
LP/J f 1.6501 1.0875 3.7878 0.0
LP/J m 1.765 1.0875 3.9026 0.0
NOD/ShiLtJ f 3.8575 1.0875 5.9951 1.7199
NOD/ShiLtJ m 3.255 1.0875 5.3926 1.1174
NON/ShiLtJ f 2.8975 1.0875 5.0351 0.7599
NON/ShiLtJ m 2.1012 1.0875 4.2389 0.0
NZW/LacJ f 9.305 1.0875 11.4426 7.1674
NZW/LacJ m 3.0687 1.0875 5.2064 0.9311
PL/J f 1.885 1.0875 4.0226 0.0
PL/J m 2.0055 1.0875 4.1431 0.0
RIIIS/J f 5.3625 1.0875 7.5001 3.2249
RIIIS/J m 4.055 1.0875 6.1926 1.9174
SJL/J f 3.4512 1.0875 5.5889 1.3136
SJL/J m 4.87 1.0875 7.0076 2.7324
SM/J f 5.4462 1.0875 7.5839 3.3086
SM/J m 5.6175 1.0875 7.7551 3.4799
SWR/J f 2.2288 1.0875 4.3664 0.0911
SWR/J m 9.8556 1.0253 11.871 7.8402


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 8.3194 0.7689 9.8309 6.8078
A/J both 12.6556 0.7689 14.1672 11.1441
AKR/J both 6.7769 0.7689 8.2884 5.2653
BALB/cByJ both 3.0394 0.7689 4.5509 1.5278
BALB/cJ both 3.08 0.6878 4.432 1.728
BTBR T+ Itpr3tf/J both 11.655 0.7689 13.1665 10.1435
BUB/BnJ both 12.4273 0.7959 13.9919 10.8627
C3H/HeJ both 3.6031 0.7689 5.1147 2.0916
C57BL/10J both 6.2845 0.7959 7.8491 4.7199
C57BL/6J both 5.5242 0.721 6.9415 4.107
C57BLKS/J both 4.5056 0.7146 5.9103 3.1009
C57BR/cdJ both 3.7417 0.8306 5.3743 2.109
C57L/J both 6.1312 0.7689 7.6428 4.6197
CBA/J both 5.3275 0.7689 6.839 3.816
CE/J both 1.9851 0.7473 3.4541 0.5162
DBA/1J both 9.9026 0.7295 11.3366 8.4686
DBA/2J both 5.4096 0.7295 6.8436 3.9756
FVB/NJ both 3.9372 0.7959 5.5018 2.3726
I/LnJ both 9.8761 0.9005 11.6463 8.106
KK/HlJ both 6.8402 0.8306 8.4729 5.2076
LP/J both 1.7076 0.7689 3.2191 0.196
NOD/ShiLtJ both 3.5563 0.7689 5.0678 2.0447
NON/ShiLtJ both 2.4994 0.7689 4.0109 0.9878
NZW/LacJ both 6.1869 0.7689 7.6984 4.6753
PL/J both 1.9453 0.7689 3.4568 0.4337
RIIIS/J both 4.7088 0.7689 6.2203 3.1972
SJL/J both 4.1606 0.7689 5.6722 2.6491
SM/J both 5.5319 0.7689 7.0434 4.0203
SWR/J both 6.0422 0.7473 7.5111 4.5732




  GWAS USING LINEAR MIXED MODELS