Project measure / variable:   Berndt2   insp_flow_slope

ID, description, units MPD:35145   insp_flow_slope   inspiratory flow rate   [mL/kg/s]  response index  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - inspiratory flow rate response index



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means0.0731   mL/kg/s 0.0926   mL/kg/s
Median of the strain means0.0988   mL/kg/s 0.136   mL/kg/s
SD of the strain means± 0.180 ± 0.188
Coefficient of variation (CV)2.46 2.03
Min–max range of strain means-0.329   –   0.364   mL/kg/s -0.292   –   0.433   mL/kg/s
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0715 0.0715 1.3301 0.2495
strain 28 13.3718 0.4776 8.8802 < 0.0001
sex:strain 28 2.1949 0.0784 1.4576 0.0644
Residuals 412 22.1569 0.0538


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.311 0.244   8 0.0861 0.782 -0.046, 0.639 1.32
129S1/SvImJ m 0.346 0.287   8 0.102 0.831 -0.058, 0.717 1.35
A/J f -0.329 0.0805   8 0.0285 -0.245 -0.436, -0.202 -2.24
A/J m -0.292 0.12   8 0.0425 -0.411 -0.516, -0.121 -2.05
AKR/J f 0.0963 0.12   8 0.0425 1.25 -0.135, 0.232 0.13
AKR/J m 0.433 0.205   8 0.0724 0.473 0.031, 0.663 1.81
BALB/cByJ f -0.0535 0.128   8 0.0452 -2.39 -0.238, 0.186 -0.7
BALB/cByJ m -0.0146 0.102   8 0.0361 -6.99 -0.241, 0.076 -0.57
BALB/cJ f -0.148 0.11   10 0.0347 -0.739 -0.335, -0.019 -1.23
BALB/cJ m -0.0899 0.157   10 0.0498 -1.75 -0.365, 0.215 -0.97
BTBR T+ Itpr3tf/J f 0.0988 0.242   8 0.0856 2.45 -0.218, 0.551 0.14
BTBR T+ Itpr3tf/J m -0.148 0.0836   8 0.0295 -0.564 -0.259, 0.002 -1.28
BUB/BnJ f 0.132 0.267   7 0.101 2.02 -0.255, 0.622 0.33
BUB/BnJ m 0.136 0.219   8 0.0773 1.61 -0.171, 0.383 0.23
C3H/HeJ f 0.0171 0.286   8 0.101 16.7 -0.45, 0.332 -0.31
C3H/HeJ m -0.0251 0.255   8 0.0901 -10.1 -0.314, 0.359 -0.63
C57BL/10J f 0.234 0.0943   8 0.0333 0.403 0.114, 0.36 0.89
C57BL/10J m 0.223 0.124   7 0.0467 0.553 -0.029, 0.338 0.69
C57BL/6J f 0.188 0.103   7 0.0388 0.546 0.053, 0.352 0.64
C57BL/6J m 0.342 0.239   13 0.0663 0.698 -0.051, 0.817 1.33
C57BLKS/J f 0.166 0.277   11 0.0834 1.67 -0.214, 0.689 0.52
C57BLKS/J m 0.191 0.304   8 0.107 1.59 -0.203, 0.762 0.52
C57BR/cdJ f 0.302 0.241   6 0.0984 0.799 -0.086, 0.546 1.27
C57BR/cdJ m 0.314 0.202   8 0.0712 0.642 0.069, 0.614 1.18
C57L/J f 0.248 0.0708   8 0.025 0.285 0.14, 0.308 0.97
C57L/J m 0.162 0.117   8 0.0413 0.72 0.37
CBA/J f 0.307 0.112   8 0.0394 0.364 0.159, 0.492 1.3
CBA/J m 0.337 0.162   8 0.0571 0.48 0.095, 0.575 1.3
CE/J f 0.0225 0.346   8 0.122 15.4 -0.334, 0.793 -0.28
CE/J m -0.0391 0.14   9 0.0466 -3.58 -0.237, 0.217 -0.7
DBA/1J f 0.283 0.163   10 0.0515 0.575 0.004, 0.488 1.17
DBA/1J m -0.0622 0.116   8 0.041 -1.86 -0.167, 0.198 -0.82
DBA/2J f 0.147 0.172   8 0.0609 1.17 -0.059, 0.5 0.41
DBA/2J m 0.207 0.221   10 0.07 1.07 -0.034, 0.665 0.61
FVB/NJ f 0.0509 0.518   8 0.183 10.2 -0.67, 0.749 -0.12
FVB/NJ m 0.23 0.399   7 0.151 1.74 -0.342, 0.686 0.73
I/LnJ f -0.0461 0.372   7 0.141 -8.07 -0.479, 0.483 -0.66
I/LnJ m -0.0236 0.377   5 0.169 -16.0 -0.452, 0.387 -0.62
KK/HlJ f 0.165 0.139   8 0.0493 0.843 -0.034, 0.351 0.51
KK/HlJ m 0.181 0.206   6 0.0841 1.14 -0.115, 0.39 0.47
LP/J f -0.169 0.272   8 0.0963 -1.61 -0.628, 0.281 -1.35
LP/J m 0.0288 0.271   8 0.0958 9.42 -0.404, 0.531 -0.34
NOD/ShiLtJ f 0.364 0.172   8 0.0608 0.473 0.175, 0.634 1.62
NOD/ShiLtJ m 0.241 0.23   8 0.0812 0.953 -0.131, 0.524 0.79
NON/ShiLtJ f -0.201 0.266   8 0.0939 -1.32 -0.694, 0.272 -1.52
NON/ShiLtJ m -0.276 0.19   8 0.067 -0.686 -0.539, 0.011 -1.96
NZW/LacJ f 0.102 0.21   8 0.0744 2.07 -0.157, 0.4 0.16
NZW/LacJ m 0.172 0.184   8 0.0649 1.07 -0.105, 0.413 0.42
PL/J f -0.227 0.164   8 0.0581 -0.725 -0.4, 0.091 -1.67
PL/J m -0.13 0.411   8 0.145 -3.16 -0.576, 0.661 -1.19
RIIIS/J f 0.164 0.0539   8 0.019 0.328 0.095, 0.235 0.51
RIIIS/J m 0.0169 0.158   8 0.0557 9.34 -0.147, 0.228 -0.4
SJL/J f -0.00988 0.408   8 0.144 -41.3 -0.446, 0.611 -0.46
SJL/J m 0.0856 0.381   8 0.135 4.45 -0.58, 0.586 -0.04
SM/J f -0.0209 0.117   8 0.0413 -5.6 -0.132, 0.18 -0.52
SM/J m -0.0296 0.193   8 0.0684 -6.53 -0.419, 0.183 -0.65
SWR/J f -0.0729 0.333   8 0.118 -4.57 -0.519, 0.363 -0.81
SWR/J m 0.17 0.167   9 0.0558 0.983 -0.096, 0.394 0.41


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.3113 0.082 0.4724 0.1501
129S1/SvImJ m 0.3456 0.082 0.5068 0.1845
A/J f -0.3285 0.082 -0.1673 -0.4897
A/J m -0.2925 0.082 -0.1313 -0.4537
AKR/J f 0.0962 0.082 0.2574 -0.0649
AKR/J m 0.4329 0.082 0.594 0.2717
BALB/cByJ f -0.0535 0.082 0.1077 -0.2147
BALB/cByJ m -0.0146 0.082 0.1465 -0.1758
BALB/cJ f -0.1484 0.0733 -0.0042 -0.2926
BALB/cJ m -0.0899 0.0733 0.0543 -0.2341
BTBR T+ Itpr3tf/J f 0.0988 0.082 0.2599 -0.0624
BTBR T+ Itpr3tf/J m -0.1482 0.082 0.0129 -0.3094
BUB/BnJ f 0.132 0.0877 0.3043 -0.0403
BUB/BnJ m 0.136 0.082 0.2972 -0.0252
C3H/HeJ f 0.0171 0.082 0.1783 -0.144
C3H/HeJ m -0.0251 0.082 0.136 -0.1863
C57BL/10J f 0.2336 0.082 0.3948 0.0725
C57BL/10J m 0.2234 0.0877 0.3957 0.0511
C57BL/6J f 0.1881 0.0877 0.3604 0.0158
C57BL/6J m 0.3424 0.0643 0.4688 0.216
C57BLKS/J f 0.1658 0.0699 0.3033 0.0284
C57BLKS/J m 0.1909 0.082 0.352 0.0297
C57BR/cdJ f 0.3017 0.0947 0.4878 0.1156
C57BR/cdJ m 0.3141 0.082 0.4753 0.153
C57L/J f 0.2485 0.082 0.4097 0.0873
C57L/J m 0.1621 0.082 0.3233 0.001
CBA/J f 0.3065 0.082 0.4677 0.1453
CBA/J m 0.3369 0.082 0.498 0.1757
CE/J f 0.0225 0.082 0.1837 -0.1387
CE/J m -0.0391 0.0773 0.1128 -0.1911
DBA/1J f 0.2831 0.0733 0.4273 0.1389
DBA/1J m -0.0622 0.082 0.0989 -0.2234
DBA/2J f 0.1467 0.082 0.3079 -0.0144
DBA/2J m 0.207 0.0733 0.3512 0.0628
FVB/NJ f 0.0509 0.082 0.212 -0.1103
FVB/NJ m 0.2297 0.0877 0.402 0.0574
I/LnJ f -0.0461 0.0877 0.1262 -0.2184
I/LnJ m -0.0236 0.1037 0.1803 -0.2275
KK/HlJ f 0.1654 0.082 0.3265 0.0042
KK/HlJ m 0.181 0.0947 0.3671 -0.0051
LP/J f -0.1695 0.082 -0.0083 -0.3307
LP/J m 0.0287 0.082 0.1899 -0.1324
NOD/ShiLtJ f 0.3636 0.082 0.5248 0.2025
NOD/ShiLtJ m 0.2409 0.082 0.402 0.0797
NON/ShiLtJ f -0.2015 0.082 -0.0403 -0.3627
NON/ShiLtJ m -0.2765 0.082 -0.1153 -0.4377
NZW/LacJ f 0.1015 0.082 0.2627 -0.0597
NZW/LacJ m 0.1716 0.082 0.3328 0.0105
PL/J f -0.2269 0.082 -0.0657 -0.388
PL/J m -0.1299 0.082 0.0313 -0.291
RIIIS/J f 0.164 0.082 0.3252 0.0028
RIIIS/J m 0.0169 0.082 0.178 -0.1443
SJL/J f -0.0099 0.082 0.1513 -0.171
SJL/J m 0.0856 0.082 0.2468 -0.0755
SM/J f -0.0209 0.082 0.1403 -0.182
SM/J m -0.0296 0.082 0.1315 -0.1908
SWR/J f -0.0729 0.082 0.0883 -0.234
SWR/J m 0.1703 0.0773 0.3223 0.0184


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.3284 0.058 0.4424 0.2145
A/J both -0.3105 0.058 -0.1965 -0.4245
AKR/J both 0.2646 0.058 0.3785 0.1506
BALB/cByJ both -0.0341 0.058 0.0799 -0.148
BALB/cJ both -0.1192 0.0519 -0.0172 -0.2211
BTBR T+ Itpr3tf/J both -0.0247 0.058 0.0892 -0.1387
BUB/BnJ both 0.134 0.06 0.252 0.016
C3H/HeJ both -0.004 0.058 0.11 -0.118
C57BL/10J both 0.2285 0.06 0.3465 0.1106
C57BL/6J both 0.2653 0.0544 0.3721 0.1584
C57BLKS/J both 0.1783 0.0539 0.2843 0.0724
C57BR/cdJ both 0.3079 0.0626 0.431 0.1848
C57L/J both 0.2053 0.058 0.3193 0.0913
CBA/J both 0.3217 0.058 0.4357 0.2077
CE/J both -0.0083 0.0563 0.1024 -0.1191
DBA/1J both 0.1104 0.055 0.2185 0.0023
DBA/2J both 0.1769 0.055 0.285 0.0688
FVB/NJ both 0.1403 0.06 0.2583 0.0223
I/LnJ both -0.0349 0.0679 0.0986 -0.1683
KK/HlJ both 0.1732 0.0626 0.2963 0.0501
LP/J both -0.0704 0.058 0.0436 -0.1843
NOD/ShiLtJ both 0.3022 0.058 0.4162 0.1883
NON/ShiLtJ both -0.239 0.058 -0.125 -0.353
NZW/LacJ both 0.1366 0.058 0.2505 0.0226
PL/J both -0.1784 0.058 -0.0644 -0.2923
RIIIS/J both 0.0904 0.058 0.2044 -0.0235
SJL/J both 0.0379 0.058 0.1518 -0.0761
SM/J both -0.0252 0.058 0.0887 -0.1392
SWR/J both 0.0487 0.0563 0.1595 -0.062




  GWAS USING LINEAR MIXED MODELS