Project measure / variable:   Berndt2   duty_cycle_slope

ID, description, units MPD:35138   duty_cycle_slope   duty cycle   [ratio]  response index  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - duty cycle response index



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means0.0933   ratio 0.104   ratio
Median of the strain means0.0922   ratio 0.108   ratio
SD of the strain means± 0.0801 ± 0.0760
Coefficient of variation (CV)0.858 0.732
Min–max range of strain means-0.0695   –   0.244   ratio -0.0526   –   0.245   ratio
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0098 0.0098 1.0591 0.304
strain 28 2.5437 0.0908 9.7939 < 0.0001
sex:strain 28 0.2542 0.0091 0.9788 0.4986
Residuals 412 3.8217 0.0093


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.244 0.129   8 0.0454 0.527 0.012, 0.355 1.88
129S1/SvImJ m 0.166 0.0939   8 0.0332 0.566 0.05, 0.289 0.82
A/J f 0.0779 0.0699   8 0.0247 0.898 0.015, 0.2 -0.19
A/J m 0.0524 0.0848   8 0.03 1.62 -0.145, 0.112 -0.68
AKR/J f 0.071 0.0786   8 0.0278 1.11 0.003, 0.25 -0.28
AKR/J m 0.108 0.0997   8 0.0353 0.924 0.008, 0.297 0.05
BALB/cByJ f 0.156 0.0977   8 0.0345 0.627 0.013, 0.28 0.78
BALB/cByJ m 0.15 0.0723   8 0.0256 0.482 0.069, 0.265 0.61
BALB/cJ f 0.144 0.068   10 0.0215 0.472 0.041, 0.227 0.63
BALB/cJ m 0.123 0.0644   10 0.0204 0.525 0.03, 0.216 0.25
BTBR T+ Itpr3tf/J f -0.019 0.0912   8 0.0323 -4.8 -0.096, 0.17 -1.4
BTBR T+ Itpr3tf/J m -0.0432 0.0541   8 0.0191 -1.25 -0.125, 0.04 -1.93
BUB/BnJ f 0.0623 0.07   7 0.0265 1.12 -0.081, 0.124 -0.39
BUB/BnJ m 0.0835 0.109   8 0.0385 1.3 -0.112, 0.21 -0.27
C3H/HeJ f 0.0948 0.0651   8 0.023 0.687 -0.005, 0.183 0.02
C3H/HeJ m 0.0876 0.0764   8 0.027 0.871 -0.057, 0.188 -0.21
C57BL/10J f 0.0922 0.0776   8 0.0274 0.842 0.002, 0.237 -0.01
C57BL/10J m 0.0857 0.0541   7 0.0205 0.632 0.027, 0.159 -0.24
C57BL/6J f 0.22 0.12   7 0.0454 0.547 0.037, 0.404 1.58
C57BL/6J m 0.196 0.0701   13 0.0195 0.357 0.101, 0.295 1.21
C57BLKS/J f 0.209 0.104   11 0.0312 0.496 0.046, 0.409 1.44
C57BLKS/J m 0.245 0.0862   8 0.0305 0.353 0.122, 0.383 1.86
C57BR/cdJ f 0.0758 0.161   6 0.0657 2.12 -0.23, 0.228 -0.22
C57BR/cdJ m 0.0936 0.113   8 0.0398 1.2 -0.085, 0.301 -0.13
C57L/J f 0.129 0.0618   8 0.0219 0.48 0.032, 0.188 0.45
C57L/J m 0.221 0.0792   8 0.028 0.358 0.097, 0.362 1.54
CBA/J f 0.16 0.0422   8 0.0149 0.264 0.097, 0.204 0.83
CBA/J m 0.141 0.0723   8 0.0256 0.515 0.026, 0.239 0.49
CE/J f 0.115 0.0692   8 0.0245 0.602 -0.019, 0.183 0.27
CE/J m 0.0762 0.1   9 0.0335 1.32 -0.086, 0.23 -0.36
DBA/1J f -0.0057 0.0964   10 0.0305 -16.9 -0.103, 0.174 -1.24
DBA/1J m 0.0304 0.121   8 0.0429 4.0 -0.09, 0.264 -0.97
DBA/2J f 0.0267 0.0902   8 0.0319 3.37 -0.119, 0.155 -0.83
DBA/2J m 0.0187 0.0303   10 0.00959 1.62 -0.03, 0.077 -1.12
FVB/NJ f 0.0502 0.0785   8 0.0277 1.56 -0.063, 0.174 -0.54
FVB/NJ m 0.115 0.0967   7 0.0365 0.842 0.023, 0.274 0.15
I/LnJ f 0.109 0.172   7 0.0652 1.58 -0.241, 0.241 0.2
I/LnJ m 0.185 0.0915   5 0.0409 0.495 0.024, 0.242 1.07
KK/HlJ f 0.168 0.11   8 0.0389 0.657 -0.047, 0.325 0.93
KK/HlJ m 0.193 0.114   6 0.0464 0.59 0.109, 0.386 1.17
LP/J f 0.0467 0.162   8 0.0573 3.46 -0.312, 0.2 -0.58
LP/J m 0.144 0.0629   8 0.0222 0.436 0.03, 0.217 0.53
NOD/ShiLtJ f 0.229 0.106   8 0.0376 0.465 0.027, 0.411 1.69
NOD/ShiLtJ m 0.154 0.194   8 0.0685 1.26 -0.228, 0.361 0.66
NON/ShiLtJ f 0.114 0.0662   8 0.0234 0.58 -0.015, 0.189 0.26
NON/ShiLtJ m 0.178 0.0896   8 0.0317 0.502 0.06, 0.312 0.98
NZW/LacJ f -0.0695 0.142   8 0.0503 -2.05 -0.355, 0.118 -2.03
NZW/LacJ m -0.0526 0.0571   8 0.0202 -1.08 -0.168, -0.002 -2.06
PL/J f -0.0254 0.118   8 0.0418 -4.66 -0.178, 0.115 -1.48
PL/J m 0.0678 0.132   8 0.0466 1.95 -0.175, 0.237 -0.47
RIIIS/J f 0.0705 0.0701   8 0.0248 0.995 -0.03, 0.201 -0.29
RIIIS/J m 0.0111 0.0342   8 0.0121 3.07 -0.025, 0.065 -1.22
SJL/J f -0.00912 0.0897   8 0.0317 -9.83 -0.118, 0.106 -1.28
SJL/J m -0.00937 0.0791   8 0.028 -8.43 -0.123, 0.095 -1.49
SM/J f 0.137 0.106   8 0.0374 0.771 0.021, 0.351 0.55
SM/J m 0.122 0.132   8 0.0465 1.08 -0.054, 0.316 0.24
SWR/J f 0.0332 0.0956   8 0.0338 2.87 -0.134, 0.13 -0.75
SWR/J m 0.0688 0.0736   9 0.0245 1.07 -0.056, 0.225 -0.46


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.244 0.0341 0.3109 0.1771
129S1/SvImJ m 0.166 0.0341 0.2329 0.0991
A/J f 0.0779 0.0341 0.1448 0.0109
A/J m 0.0524 0.0341 0.1193 -0.0146
AKR/J f 0.071 0.0341 0.1379 0.0041
AKR/J m 0.108 0.0341 0.1749 0.0411
BALB/cByJ f 0.1559 0.0341 0.2228 0.0889
BALB/cByJ m 0.15 0.0341 0.2169 0.0831
BALB/cJ f 0.144 0.0305 0.2039 0.0841
BALB/cJ m 0.1227 0.0305 0.1826 0.0628
BTBR T+ Itpr3tf/J f -0.019 0.0341 0.0479 -0.0859
BTBR T+ Itpr3tf/J m -0.0432 0.0341 0.0237 -0.1102
BUB/BnJ f 0.0623 0.0364 0.1338 -0.0093
BUB/BnJ m 0.0835 0.0341 0.1504 0.0166
C3H/HeJ f 0.0948 0.0341 0.1617 0.0278
C3H/HeJ m 0.0876 0.0341 0.1546 0.0207
C57BL/10J f 0.0923 0.0341 0.1592 0.0253
C57BL/10J m 0.0857 0.0364 0.1573 0.0142
C57BL/6J f 0.2196 0.0364 0.2911 0.148
C57BL/6J m 0.1964 0.0267 0.2489 0.1439
C57BLKS/J f 0.209 0.029 0.2661 0.1519
C57BLKS/J m 0.2446 0.0341 0.3116 0.1777
C57BR/cdJ f 0.0758 0.0393 0.1531 -0.0015
C57BR/cdJ m 0.0936 0.0341 0.1606 0.0267
C57L/J f 0.1288 0.0341 0.1957 0.0618
C57L/J m 0.221 0.0341 0.2879 0.1541
CBA/J f 0.16 0.0341 0.2269 0.0931
CBA/J m 0.1405 0.0341 0.2074 0.0736
CE/J f 0.115 0.0341 0.1819 0.0481
CE/J m 0.0762 0.0321 0.1393 0.0131
DBA/1J f -0.0057 0.0305 0.0542 -0.0656
DBA/1J m 0.0304 0.0341 0.0973 -0.0366
DBA/2J f 0.0268 0.0341 0.0937 -0.0402
DBA/2J m 0.0187 0.0305 0.0786 -0.0412
FVB/NJ f 0.0503 0.0341 0.1172 -0.0167
FVB/NJ m 0.1149 0.0364 0.1864 0.0433
I/LnJ f 0.1089 0.0364 0.1804 0.0373
I/LnJ m 0.1848 0.0431 0.2695 0.1001
KK/HlJ f 0.1677 0.0341 0.2347 0.1008
KK/HlJ m 0.1925 0.0393 0.2698 0.1152
LP/J f 0.0467 0.0341 0.1137 -0.0202
LP/J m 0.1441 0.0341 0.2111 0.0772
NOD/ShiLtJ f 0.2289 0.0341 0.2958 0.1619
NOD/ShiLtJ m 0.1536 0.0341 0.2206 0.0867
NON/ShiLtJ f 0.114 0.0341 0.1809 0.0471
NON/ShiLtJ m 0.1784 0.0341 0.2453 0.1114
NZW/LacJ f -0.0695 0.0341 -0.0026 -0.1364
NZW/LacJ m -0.0526 0.0341 0.0143 -0.1196
PL/J f -0.0254 0.0341 0.0416 -0.0923
PL/J m 0.0678 0.0341 0.1347 0.0008
RIIIS/J f 0.0705 0.0341 0.1374 0.0036
RIIIS/J m 0.0111 0.0341 0.0781 -0.0558
SJL/J f -0.0091 0.0341 0.0578 -0.0761
SJL/J m -0.0094 0.0341 0.0576 -0.0763
SM/J f 0.137 0.0341 0.2039 0.0701
SM/J m 0.1221 0.0341 0.1891 0.0552
SWR/J f 0.0332 0.0341 0.1002 -0.0337
SWR/J m 0.0688 0.0321 0.1319 0.0057


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.205 0.0241 0.2523 0.1577
A/J both 0.0651 0.0241 0.1125 0.0178
AKR/J both 0.0895 0.0241 0.1368 0.0422
BALB/cByJ both 0.1529 0.0241 0.2003 0.1056
BALB/cJ both 0.1334 0.0215 0.1757 0.091
BTBR T+ Itpr3tf/J both -0.0311 0.0241 0.0162 -0.0785
BUB/BnJ both 0.0729 0.0249 0.1219 0.0239
C3H/HeJ both 0.0912 0.0241 0.1385 0.0439
C57BL/10J both 0.089 0.0249 0.138 0.04
C57BL/6J both 0.208 0.0226 0.2524 0.1636
C57BLKS/J both 0.2268 0.0224 0.2708 0.1828
C57BR/cdJ both 0.0847 0.026 0.1359 0.0336
C57L/J both 0.1749 0.0241 0.2222 0.1275
CBA/J both 0.1502 0.0241 0.1976 0.1029
CE/J both 0.0956 0.0234 0.1416 0.0496
DBA/1J both 0.0123 0.0228 0.0572 -0.0326
DBA/2J both 0.0227 0.0228 0.0676 -0.0222
FVB/NJ both 0.0826 0.0249 0.1315 0.0336
I/LnJ both 0.1468 0.0282 0.2023 0.0914
KK/HlJ both 0.1801 0.026 0.2312 0.129
LP/J both 0.0954 0.0241 0.1428 0.0481
NOD/ShiLtJ both 0.1912 0.0241 0.2386 0.1439
NON/ShiLtJ both 0.1462 0.0241 0.1935 0.0989
NZW/LacJ both -0.0611 0.0241 -0.0137 -0.1084
PL/J both 0.0212 0.0241 0.0685 -0.0261
RIIIS/J both 0.0408 0.0241 0.0881 -0.0065
SJL/J both -0.0092 0.0241 0.0381 -0.0566
SM/J both 0.1296 0.0241 0.1769 0.0822
SWR/J both 0.051 0.0234 0.097 0.005




  GWAS USING LINEAR MIXED MODELS