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Project measure / variable:   Shockley1   T4_fat

ID, description, units MPD:33440   T4_fat   thyroxine (T4)   [µg/dL]  high-fat diet  
high-fat diet study
Data set, strains Shockley1   inbred   10 strains     sex: both     age: 10-13wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Shockley1 - thyroxine (T4) high-fat diet



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means7.95   µg/dL 6.15   µg/dL
Median of the strain means7.43   µg/dL 5.66   µg/dL
SD of the strain means± 2.63 ± 2.47
Coefficient of variation (CV)0.331 0.401
Min–max range of strain means3.73   –   12.3   µg/dL 3.12   –   12.2   µg/dL
Mean sample size per strain4.2   mice 4.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 120.7958 120.7958 90.9627 < 0.0001
strain 9 306.7369 34.0819 25.6646 < 0.0001
sex:strain 9 105.0117 11.668 8.7863 < 0.0001
Residuals 63 83.6622 1.328


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 6.73 1.21   3 0.696 0.179 5.6, 8.0 -0.46
129S1/SvImJ m 5.22 0.76   5 0.34 0.146 4.4, 6.1 -0.38
A/J f 7.43 1.35   4 0.675 0.182 5.4, 8.1 -0.2
A/J m 7.22 1.19   5 0.53 0.164 5.3, 8.2 0.43
BALB/cJ f 12.3 1.23   5 0.549 0.0996 10.4, 13.8 1.65
BALB/cJ m 6.62 0.76   5 0.34 0.115 5.7, 7.6 0.19
C3H/HeJ f 11.8 2.07   5 0.928 0.176 9.5, 15.1 1.46
C3H/HeJ m 12.2 1.63   2   1.15 0.133 11.1, 13.4 2.45
C57BL/6J f 7.23 0.924   3 0.533 0.128 6.7, 8.3 -0.27
C57BL/6J m 4.7 1.56   2   1.1 0.331 3.6, 5.8 -0.59
DBA/2J f 9.12 1.66   5 0.742 0.182 7.3, 10.9 0.44
DBA/2J m 6.83 1.15   3 0.667 0.169 5.5, 7.5 0.28
I/LnJ f 3.73 0.808   3 0.467 0.217 3.0, 4.6 -1.6
I/LnJ m 6.1 0.711   5 0.318 0.116 5.4, 7.1 -0.02
MRL/MpJ-Faslpr/J f 5.36 0.537   5 0.24 0.1 4.9, 6.2 -0.98
MRL/MpJ-Faslpr/J m 4.44 0.385   5 0.172 0.0866 4.0, 4.9 -0.69
NZB/BlNJ f 7.43 0.732   4 0.366 0.0986 6.4, 8.0 -0.2
NZB/BlNJ m 3.12 0.768   4 0.384 0.246 2.3, 4.1 -1.23
SM/J f 8.4 1.59   5 0.709 0.189 6.4, 10.4 0.17
SM/J m 5.04 0.844   5 0.378 0.168 3.6, 5.7 -0.45


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 6.7333 0.6653 8.0629 5.4038
129S1/SvImJ m 5.22 0.5154 6.2499 4.1901
A/J f 7.425 0.5762 8.5764 6.2736
A/J m 7.22 0.5154 8.2499 6.1901
BALB/cJ f 12.32 0.5154 13.3499 11.2901
BALB/cJ m 6.62 0.5154 7.6499 5.5901
C3H/HeJ f 11.76 0.5154 12.7899 10.7301
C3H/HeJ m 12.25 0.8149 13.8784 10.6216
C57BL/6J f 7.2333 0.6653 8.5629 5.9038
C57BL/6J m 4.7 0.8149 6.3284 3.0716
DBA/2J f 9.12 0.5154 10.1499 8.0901
DBA/2J m 6.8333 0.6653 8.1629 5.5038
I/LnJ f 3.7333 0.6653 5.0629 2.4038
I/LnJ m 6.1 0.5154 7.1299 5.0701
MRL/MpJ-Faslpr/J f 5.36 0.5154 6.3899 4.3301
MRL/MpJ-Faslpr/J m 4.44 0.5154 5.4699 3.4101
NZB/BlNJ f 7.425 0.5762 8.5764 6.2736
NZB/BlNJ m 3.125 0.5762 4.2764 1.9736
SM/J f 8.4 0.5154 9.4299 7.3701
SM/J m 5.04 0.5154 6.0699 4.0101


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 5.9767 0.4208 6.8175 5.1358
A/J both 7.3225 0.3865 8.0949 6.5501
BALB/cJ both 9.47 0.3644 10.1982 8.7418
C3H/HeJ both 12.005 0.4821 12.9683 11.0417
C57BL/6J both 5.9667 0.526 7.0178 4.9156
DBA/2J both 7.9767 0.4208 8.8175 7.1358
I/LnJ both 4.9167 0.4208 5.7575 4.0758
MRL/MpJ-Faslpr/J both 4.9 0.3644 5.6282 4.1718
NZB/BlNJ both 5.275 0.4074 6.0892 4.4608
SM/J both 6.72 0.3644 7.4482 5.9918




  GWAS USING LINEAR MIXED MODELS