Project measure / variable:   Maurer1   QT_iso1

ID, description, units MPD:33247   QT_iso1   interval QT   [ms]  isoprot 1mg  
atenolol, isoproterenol study
Data set, strains Maurer1   inbred   23 strains     sex: m     age: 7-13wks
Procedure ECG
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  STRAIN COMPARISON PLOT
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Maurer1 - interval QT isoprot 1mg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested23 strains
Mean of the strain means51.1   ms
Median of the strain means50.2   ms
SD of the strain means± 5.34
Coefficient of variation (CV)0.105
Min–max range of strain means42.6   –   62.2   ms
Mean sample size per strain10.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 22 5741.0887 260.9586 4.1373 < 0.0001
Residuals 207 13056.3426 63.0741


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 49.6 7.66   13 2.13 0.154 30.5, 61.3 -0.28
A/J m 53.0 10.6   10 3.35 0.2 37.6, 73.1 0.36
AKR/J m 55.1 4.01   10 1.27 0.0728 46.6, 60.3 0.75
BALB/cByJ m 57.2 11.0   9 3.67 0.192 34.6, 68.5 1.15
BALB/cJ m 51.3 5.38   10 1.7 0.105 39.0, 57.3 0.04
BTBR T+ Itpr3tf/J m 56.7 5.97   9 1.99 0.105 50.4, 66.5 1.05
C3H/HeJ m 45.3 11.7   9 3.9 0.259 30.6, 68.9 -1.08
C3H/HeOuJ m 50.2 4.24   10 1.34 0.0843 44.7, 58.5 -0.16
C57BL/6J m 45.9 2.19   9 0.731 0.0478 41.6, 48.5 -0.97
C57BLKS/J m 49.8 8.16   10 2.58 0.164 31.7, 58.5 -0.24
C58/J m 49.1 5.62   12 1.62 0.114 40.5, 60.8 -0.37
CBA/J m 48.9 9.75   10 3.08 0.199 34.2, 63.8 -0.41
DBA/2J m 62.2 15.0   7 5.66 0.241 45.9, 84.8 2.08
FVB/NJ m 50.5 6.29   13 1.74 0.125 39.4, 58.2 -0.11
I/LnJ m 42.6 8.59   9 2.86 0.202 30.0, 62.0 -1.59
KK/HlJ m 55.7 3.22   10 1.02 0.0577 49.0, 60.8 0.87
LP/J m 50.6 2.78   10 0.88 0.055 45.9, 54.2 -0.09
NOD/ShiLtJ m 46.2 6.71   10 2.12 0.145 32.0, 55.5 -0.91
NZB/BlNJ m 45.5 3.24   9 1.08 0.0711 38.8, 49.0 -1.04
PL/J m 59.8 16.6   9 5.55 0.278 42.5, 97.6 1.63
SJL/J m 44.8 6.43   9 2.14 0.144 36.3, 52.8 -1.18
SM/J m 58.4 6.4   14 1.71 0.11 48.2, 75.1 1.37
SWR/J m 46.3 7.45   9 2.48 0.161 34.2, 57.0 -0.89


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 49.6231 2.2027 53.9657 45.2805
A/J m 53.05 2.5115 58.0013 48.0987
AKR/J m 55.09 2.5115 60.0413 50.1387
BALB/cByJ m 57.1667 2.6473 62.3858 51.9475
BALB/cJ m 51.33 2.5115 56.2813 46.3787
BTBR T+ Itpr3tf/J m 56.6556 2.6473 61.8747 51.4364
C3H/HeJ m 45.2778 2.6473 50.4969 40.0586
C3H/HeOuJ m 50.25 2.5115 55.2013 45.2987
C57BL/6J m 45.8889 2.6473 51.108 40.6697
C57BLKS/J m 49.82 2.5115 54.7713 44.8687
C58/J m 49.0833 2.2926 53.6032 44.5634
CBA/J m 48.89 2.5115 53.8413 43.9387
DBA/2J m 62.1714 3.0018 68.0894 56.2535
FVB/NJ m 50.4615 2.2027 54.8041 46.119
I/LnJ m 42.5556 2.6473 47.7747 37.3364
KK/HlJ m 55.73 2.5115 60.6813 50.7787
LP/J m 50.64 2.5115 55.5913 45.6887
NOD/ShiLtJ m 46.21 2.5115 51.1613 41.2587
NZB/BlNJ m 45.5222 2.6473 50.7414 40.3031
PL/J m 59.7667 2.6473 64.9858 54.5475
SJL/J m 44.7667 2.6473 49.9858 39.5475
SM/J m 58.3643 2.1226 62.5489 54.1797
SWR/J m 46.3444 2.6473 51.5636 41.1253




  GWAS USING LINEAR MIXED MODELS