Project measure / variable:   Yuan3   T4_M18

ID, description, units MPD:24478   T4_M18   thyroxine (serum T4)   [µg/dL]  at age 18mo  
Data set, strains Yuan3   inbred   29 strains     sex: both     age: 78wks
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  STRAIN COMPARISON PLOT
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Yuan3 - thyroxine (serum T4) at age 18mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains28 strains
Mean of the strain means4.13   µg/dL 4.03   µg/dL
Median of the strain means4.04   µg/dL 3.95   µg/dL
SD of the strain means± 1.12 ± 1.12
Coefficient of variation (CV)0.271 0.278
Min–max range of strain means2.27   –   6.53   µg/dL 1.86   –   6.30   µg/dL
Mean sample size per strain7.2   mice 6.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.1072 0.1072 0.1171 0.7325
strain 26 310.611 11.9466 13.0496 < 0.0001
sex:strain 26 96.4764 3.7106 4.0532 < 0.0001
Residuals 315 288.3742 0.9155


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3.94 0.378   7 0.143 0.0959 3.3, 4.4 -0.17
129S1/SvImJ m 3.54 0.385   8 0.136 0.109 3.0, 4.2 -0.43
A/J f 4.26 1.4   8 0.496 0.329 2.0, 5.6 0.12
A/J m 3.55 1.35   6 0.549 0.379 1.8, 4.7 -0.43
BALB/cByJ f 5.44 0.559   7 0.211 0.103 4.9, 6.5 1.18
BALB/cByJ m 3.57 0.612   6 0.25 0.172 2.5, 4.2 -0.41
BTBR T+ Itpr3tf/J f 3.02 1.69   6 0.689 0.559 0.5, 4.9 -0.99
BTBR T+ Itpr3tf/J m 3.14 1.19   5 0.533 0.379 1.3, 4.6 -0.79
BUB/BnJ f 2.68 0.531   5 0.237 0.198 2.1, 3.3 -1.3
C3H/HeJ f 3.6 1.82   6 0.744 0.506 0.4, 5.8 -0.47
C3H/HeJ m 4.26 1.29   8 0.455 0.302 2.3, 5.7 0.21
C57BL/10J f 6.53 0.515   7 0.195 0.079 5.7, 7.2 2.15
C57BL/10J m 5.26 1.26   7 0.478 0.241 2.7, 6.5 1.1
C57BL/6J f 4.7 0.941   8 0.333 0.2 3.9, 6.7 0.51
C57BL/6J m 6.3 0.856   6 0.349 0.136 5.3, 7.9 2.03
C57BLKS/J f 4.31 1.69   7 0.638 0.391 1.0, 6.4 0.16
C57BLKS/J m 5.2 0.646   8 0.228 0.124 4.1, 6.0 1.05
C57BR/cdJ f 5.09 0.982   8 0.347 0.193 3.8, 6.9 0.86
C57BR/cdJ m 3.95 0.717   8 0.254 0.182 2.9, 4.9 -0.07
C57L/J f 4.67 0.592   8 0.209 0.127 4.0, 5.6 0.49
C57L/J m 4.75 0.779   6 0.318 0.164 3.9, 5.9 0.64
CBA/J f 5.9 1.53   8 0.539 0.258 2.9, 7.6 1.59
CBA/J m 5.5 0.775   6 0.316 0.141 4.2, 6.2 1.31
DBA/2J f 5.38 0.766   5 0.343 0.142 4.7, 6.4 1.12
DBA/2J m 4.1 1.07   8 0.38 0.262 2.0, 5.7 0.07
FVB/NJ f 3.06 0.262   8 0.0925 0.0854 2.5, 3.3 -0.95
FVB/NJ m 2.48 0.427   5 0.191 0.172 2.0, 2.9 -1.38
KK/HlJ f 3.19 1.03   10 0.325 0.323 1.6, 5.0 -0.84
KK/HlJ m 5.09 1.43   7 0.54 0.281 2.3, 6.4 0.95
LP/J f 3.14 0.391   7 0.148 0.124 2.4, 3.5 -0.88
LP/J m 3.94 0.521   8 0.184 0.132 3.2, 4.7 -0.08
MRL/MpJ f 3.1 0.141   2   0.1 0.0456 3.0, 3.2 -0.92
MRL/MpJ m 1.86 0.77   5 0.344 0.414 0.8, 2.6 -1.93
NOD.B10Sn-H2b/J f 3.03 1.28   7 0.483 0.422 0.5, 4.4 -0.98
NOD.B10Sn-H2b/J m 4.45 0.742   4 0.371 0.167 3.4, 5.1 0.38
NON/ShiLtJ f 3.68 0.624   14 0.167 0.17 2.8, 4.7 -0.4
NON/ShiLtJ m 3.76 0.637   7 0.241 0.17 2.5, 4.4 -0.24
NZO/HlLtJ f 4.41 0.701   9 0.234 0.159 3.1, 5.5 0.25
NZO/HlLtJ m 2.2 0.0   1   0.0 0.0 2.2, 2.2 -1.63
NZW/LacJ f 5.04 1.02   5 0.457 0.203 3.4, 6.0 0.82
NZW/LacJ m 4.61 0.997   7 0.377 0.216 3.3, 6.2 0.52
P/J f 4.76 1.82   5 0.815 0.383 2.7, 7.5 0.57
P/J m 5.08 1.25   4 0.626 0.247 3.8, 6.8 0.94
PL/J f 3.44 0.866   7 0.327 0.251 2.3, 4.9 -0.61
PL/J m 5.78 0.45   4 0.225 0.0779 5.4, 6.4 1.56
PWD/PhJ f 6.27 0.734   7 0.278 0.117 5.3, 7.0 1.92
PWD/PhJ m 4.77 0.58   8 0.205 0.121 4.0, 5.6 0.66
RIIIS/J f 4.04 0.828   8 0.293 0.205 2.5, 5.1 -0.08
RIIIS/J m 3.7 0.321   8 0.113 0.0867 3.3, 4.2 -0.29
SJL/J f 2.98 0.838   8 0.296 0.282 1.4, 3.8 -1.03
SJL/J m 2.87 1.19   6 0.484 0.414 1.6, 4.6 -1.03
SM/J f 4.47 0.725   7 0.274 0.162 3.4, 5.2 0.31
SM/J m 3.4 0.919   5 0.411 0.27 2.2, 4.4 -0.56
SWR/J f 3.26 1.22   8 0.432 0.375 1.4, 4.9 -0.78
SWR/J m 2.93 0.55   6 0.225 0.188 1.9, 3.4 -0.98
WSB/EiJ f 2.27 0.544   8 0.192 0.239 1.5, 3.0 -1.66
WSB/EiJ m 2.71 0.434   7 0.164 0.16 1.9, 3.2 -1.17


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3.9429 0.3616 4.6544 3.2313
129S1/SvImJ m 3.5375 0.3383 4.2031 2.8719
A/J f 4.2625 0.3383 4.9281 3.5969
A/J m 3.55 0.3906 4.3185 2.7815
BALB/cByJ f 5.4429 0.3616 6.1544 4.7313
BALB/cByJ m 3.5667 0.3906 4.3352 2.7981
BTBR T+ Itpr3tf/J f 3.0167 0.3906 3.7852 2.2481
BTBR T+ Itpr3tf/J m 3.14 0.4279 3.9819 2.2981
C3H/HeJ f 3.6 0.3906 4.3685 2.8315
C3H/HeJ m 4.2625 0.3383 4.9281 3.5969
C57BL/10J f 6.5286 0.3616 7.2401 5.817
C57BL/10J m 5.2571 0.3616 5.9687 4.5456
C57BL/6J f 4.7 0.3383 5.3656 4.0344
C57BL/6J m 6.3 0.3906 7.0685 5.5315
C57BLKS/J f 4.3143 0.3616 5.0258 3.6028
C57BLKS/J m 5.2 0.3383 5.8656 4.5344
C57BR/cdJ f 5.0875 0.3383 5.7531 4.4219
C57BR/cdJ m 3.95 0.3383 4.6156 3.2844
C57L/J f 4.675 0.3383 5.3406 4.0094
C57L/J m 4.75 0.3906 5.5185 3.9815
CBA/J f 5.9 0.3383 6.5656 5.2344
CBA/J m 5.5 0.3906 6.2685 4.7315
DBA/2J f 5.38 0.4279 6.2219 4.5381
DBA/2J m 4.1 0.3383 4.7656 3.4344
FVB/NJ f 3.0625 0.3383 3.7281 2.3969
FVB/NJ m 2.48 0.4279 3.3219 1.6381
KK/HlJ f 3.19 0.3026 3.7853 2.5947
KK/HlJ m 5.0857 0.3616 5.7972 4.3742
LP/J f 3.1429 0.3616 3.8544 2.4313
LP/J m 3.9375 0.3383 4.6031 3.2719
MRL/MpJ f 3.1 0.6766 4.4312 1.7688
MRL/MpJ m 1.86 0.4279 2.7019 1.0181
NOD.B10Sn-H2b/J f 3.0286 0.3616 3.7401 2.317
NOD.B10Sn-H2b/J m 4.45 0.4784 5.3913 3.5087
NON/ShiLtJ f 3.6786 0.2557 4.1817 3.1754
NON/ShiLtJ m 3.7571 0.3616 4.4687 3.0456
NZW/LacJ f 5.04 0.4279 5.8819 4.1981
NZW/LacJ m 4.6143 0.3616 5.3258 3.9028
P/J f 4.76 0.4279 5.6019 3.9181
P/J m 5.075 0.4784 6.0163 4.1337
PL/J f 3.4429 0.3616 4.1544 2.7313
PL/J m 5.775 0.4784 6.7163 4.8337
PWD/PhJ f 6.2714 0.3616 6.983 5.5599
PWD/PhJ m 4.775 0.3383 5.4406 4.1094
RIIIS/J f 4.0375 0.3383 4.7031 3.3719
RIIIS/J m 3.7 0.3383 4.3656 3.0344
SJL/J f 2.975 0.3383 3.6406 2.3094
SJL/J m 2.8667 0.3906 3.6352 2.0981
SM/J f 4.4714 0.3616 5.183 3.7599
SM/J m 3.4 0.4279 4.2419 2.5581
SWR/J f 3.2625 0.3383 3.9281 2.5969
SWR/J m 2.9333 0.3906 3.7019 2.1648
WSB/EiJ f 2.275 0.3383 2.9406 1.6094
WSB/EiJ m 2.7143 0.3616 3.4258 2.0028


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3.7402 0.2476 4.2273 3.253
A/J both 3.9063 0.2584 4.4146 3.3979
BALB/cByJ both 4.5048 0.2662 5.0284 3.9811
BTBR T+ Itpr3tf/J both 3.0783 0.2897 3.6483 2.5084
C3H/HeJ both 3.9313 0.2584 4.4396 3.4229
C57BL/10J both 5.8929 0.2557 6.396 5.3897
C57BL/6J both 5.5 0.2584 6.0083 4.9917
C57BLKS/J both 4.7571 0.2476 5.2443 4.27
C57BR/cdJ both 4.5187 0.2392 4.9894 4.0481
C57L/J both 4.7125 0.2584 5.2208 4.2042
CBA/J both 5.7 0.2584 6.2083 5.1917
DBA/2J both 4.74 0.2727 5.2766 4.2034
FVB/NJ both 2.7712 0.2727 3.3079 2.2346
KK/HlJ both 4.1379 0.2358 4.6017 3.674
LP/J both 3.5402 0.2476 4.0273 3.053
MRL/MpJ both 2.48 0.4003 3.2675 1.6925
NOD.B10Sn-H2b/J both 3.7393 0.2999 4.3293 3.1493
NON/ShiLtJ both 3.7179 0.2215 4.1536 3.2821
NZW/LacJ both 4.8271 0.2801 5.3783 4.276
P/J both 4.9175 0.3209 5.5489 4.2861
PL/J both 4.6089 0.2999 5.1989 4.019
PWD/PhJ both 5.5232 0.2476 6.0104 5.0361
RIIIS/J both 3.8687 0.2392 4.3394 3.3981
SJL/J both 2.9208 0.2584 3.4292 2.4125
SM/J both 3.9357 0.2801 4.4869 3.3846
SWR/J both 3.0979 0.2584 3.6063 2.5896
WSB/EiJ both 2.4946 0.2476 2.9818 2.0075




  GWAS USING LINEAR MIXED MODELS