Project measure / variable:   Yuan3   T4_M12

ID, description, units MPD:24477   T4_M12   thyroxine (serum T4)   [µg/dL]  at age 12mo  
Data set, strains Yuan3   inbred   31 strains     sex: both     age: 52wks
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  STRAIN COMPARISON PLOT
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Yuan3 - thyroxine (serum T4) at age 12mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested31 strains29 strains
Mean of the strain means5.00   µg/dL 4.89   µg/dL
Median of the strain means5.36   µg/dL 4.89   µg/dL
SD of the strain means± 1.29 ± 1.41
Coefficient of variation (CV)0.258 0.288
Min–max range of strain means1.77   –   7.53   µg/dL 1.65   –   7.14   µg/dL
Mean sample size per strain7.2   mice 7.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.1506 0.1506 0.1866 0.666
strain 28 482.3159 17.2256 21.3412 < 0.0001
sex:strain 28 158.0275 5.6438 6.9923 < 0.0001
Residuals 360 290.5748 0.8072


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 4.78 1.02   8 0.359 0.213 3.8, 6.5 -0.17
129S1/SvImJ m 4.62 0.528   8 0.187 0.114 3.9, 5.5 -0.19
A/J f 4.52 0.833   6 0.34 0.184 3.2, 5.7 -0.38
A/J m 5.29 0.66   16 0.165 0.125 4.2, 6.5 0.28
AKR/J f 3.7 0.283   2   0.2 0.0764 3.5, 3.9 -1.01
AKR/J m 2.07 1.54   3 0.888 0.744 0.3, 3.1 -2.0
BALB/cByJ f 5.7 0.857   8 0.303 0.15 4.6, 7.1 0.54
BALB/cByJ m 3.7 1.65   8 0.584 0.446 0.5, 5.7 -0.84
BTBR T+ Itpr3tf/J f 4.85 0.639   8 0.226 0.132 4.1, 5.9 -0.12
BTBR T+ Itpr3tf/J m 4.44 0.465   7 0.176 0.105 3.9, 5.4 -0.32
BUB/BnJ f 3.2 1.08   6 0.441 0.338 1.8, 4.7 -1.4
BUB/BnJ m 6.45 1.29   10 0.407 0.2 4.3, 8.6 1.11
C3H/HeJ f 5.87 0.944   8 0.334 0.161 3.9, 6.9 0.67
C3H/HeJ m 6.6 0.619   7 0.234 0.0938 6.0, 7.8 1.21
C57BL/10J f 6.73 0.723   7 0.273 0.107 5.9, 7.8 1.34
C57BL/10J m 6.31 0.843   7 0.319 0.134 5.2, 7.5 1.01
C57BL/6J f 6.16 0.785   8 0.278 0.127 5.3, 7.7 0.9
C57BL/6J m 6.31 0.352   8 0.125 0.0558 5.7, 6.7 1.01
C57BLKS/J f 4.9 0.789   8 0.279 0.161 3.7, 6.0 -0.08
C57BLKS/J m 6.05 0.586   8 0.207 0.0968 5.0, 7.0 0.82
C57BR/cdJ f 5.44 0.803   8 0.284 0.148 4.4, 7.0 0.34
C57BR/cdJ m 5.82 1.08   8 0.383 0.186 4.7, 7.8 0.66
C57L/J f 5.44 1.11   7 0.419 0.204 4.0, 7.0 0.34
C57L/J m 4.89 0.882   8 0.312 0.181 3.6, 6.4 0.0
CAST/EiJ f 3.36 0.329   8 0.116 0.0979 3.0, 3.8 -1.28
CBA/J f 7.53 0.582   7 0.22 0.0773 6.7, 8.1 1.96
CBA/J m 5.13 1.67   6 0.682 0.326 2.9, 6.9 0.17
DBA/2J f 5.22 1.06   6 0.432 0.203 3.4, 6.2 0.17
DBA/2J m 5.44 0.665   7 0.252 0.122 4.3, 6.3 0.39
FVB/NJ f 3.89 0.352   8 0.125 0.0906 3.5, 4.4 -0.86
FVB/NJ m 2.51 0.72   8 0.255 0.287 1.5, 3.7 -1.69
KK/HlJ f 6.17 1.19   8 0.42 0.193 4.6, 7.8 0.9
KK/HlJ m 7.14 1.74   8 0.614 0.243 3.9, 9.5 1.6
LP/J f 3.69 0.819   7 0.31 0.222 2.7, 4.9 -1.02
LP/J m 3.87 0.729   8 0.258 0.188 2.9, 4.8 -0.72
MRL/MpJ f 3.38 0.656   8 0.232 0.194 2.2, 4.2 -1.26
MRL/MpJ m 3.67 1.75   7 0.661 0.476 2.2, 6.4 -0.87
NOD.B10Sn-H2b/J f 5.75 0.734   6 0.3 0.128 4.7, 6.7 0.58
NOD.B10Sn-H2b/J m 5.54 0.476   7 0.18 0.0858 4.7, 6.1 0.46
NON/ShiLtJ f 5.36 0.585   8 0.207 0.109 4.5, 6.2 0.28
NON/ShiLtJ m 4.66 0.85   7 0.321 0.183 3.6, 6.0 -0.16
NZO/HlLtJ f 5.56 0.583   7 0.22 0.105 4.5, 6.3 0.43
NZO/HlLtJ m 4.23 1.3   6 0.531 0.307 2.6, 5.9 -0.47
NZW/LacJ f 5.47 0.648   8 0.229 0.118 4.4, 6.6 0.36
NZW/LacJ m 5.98 0.684   8 0.242 0.114 5.2, 7.0 0.77
P/J f 5.76 0.86   8 0.304 0.149 4.9, 7.2 0.59
PL/J f 4.63 1.45   3 0.835 0.312 3.7, 6.3 -0.29
PL/J m 6.92 0.563   5 0.252 0.0814 6.3, 7.8 1.44
PWD/PhJ f 6.69 1.34   8 0.475 0.201 3.9, 8.2 1.31
PWD/PhJ m 4.58 0.752   8 0.266 0.164 3.1, 5.5 -0.22
RIIIS/J f 5.64 0.493   8 0.174 0.0874 4.9, 6.4 0.49
RIIIS/J m 5.83 0.68   8 0.24 0.117 4.4, 6.8 0.67
SJL/J f 3.35 0.653   6 0.267 0.195 2.2, 4.2 -1.28
SJL/J m 4.17 0.9   4 0.45 0.215 2.9, 5.0 -0.51
SM/J f 6.74 0.476   7 0.18 0.0705 6.2, 7.4 1.35
SM/J m 4.56 0.951   9 0.317 0.209 2.9, 5.7 -0.23
SWR/J f 3.9 0.421   9 0.14 0.108 3.3, 4.4 -0.86
SWR/J m 3.37 0.916   7 0.346 0.272 2.0, 4.8 -1.08
WSB/EiJ f 1.77 0.39   7 0.148 0.22 1.2, 2.3 -2.51
WSB/EiJ m 1.65 0.354   2   0.25 0.214 1.4, 1.9 -2.3


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 4.775 0.3176 5.3997 4.1503
129S1/SvImJ m 4.625 0.3176 5.2497 4.0003
A/J f 4.5167 0.3668 5.238 3.7954
A/J m 5.2938 0.2246 5.7355 4.852
AKR/J f 3.7 0.6353 4.9493 2.4507
AKR/J m 2.0667 0.5187 3.0867 1.0466
BALB/cByJ f 5.7 0.3176 6.3247 5.0753
BALB/cByJ m 3.7 0.3176 4.3247 3.0753
BTBR T+ Itpr3tf/J f 4.85 0.3176 5.4747 4.2253
BTBR T+ Itpr3tf/J m 4.4429 0.3396 5.1106 3.7751
BUB/BnJ f 3.2 0.3668 3.9213 2.4787
BUB/BnJ m 6.45 0.2841 7.0087 5.8913
C3H/HeJ f 5.875 0.3176 6.4997 5.2503
C3H/HeJ m 6.6 0.3396 7.2678 5.9322
C57BL/10J f 6.7286 0.3396 7.3964 6.0608
C57BL/10J m 6.3143 0.3396 6.9821 5.6465
C57BL/6J f 6.1625 0.3176 6.7872 5.5378
C57BL/6J m 6.3125 0.3176 6.9372 5.6878
C57BLKS/J f 4.9 0.3176 5.5247 4.2753
C57BLKS/J m 6.05 0.3176 6.6747 5.4253
C57BR/cdJ f 5.4375 0.3176 6.0622 4.8128
C57BR/cdJ m 5.825 0.3176 6.4497 5.2003
C57L/J f 5.4429 0.3396 6.1106 4.7751
C57L/J m 4.8875 0.3176 5.5122 4.2628
CBA/J f 7.5286 0.3396 8.1964 6.8608
CBA/J m 5.1333 0.3668 5.8546 4.412
DBA/2J f 5.2167 0.3668 5.938 4.4954
DBA/2J m 5.4429 0.3396 6.1106 4.7751
FVB/NJ f 3.8875 0.3176 4.5122 3.2628
FVB/NJ m 2.5125 0.3176 3.1372 1.8878
KK/HlJ f 6.175 0.3176 6.7997 5.5503
KK/HlJ m 7.1375 0.3176 7.7622 6.5128
LP/J f 3.6857 0.3396 4.3535 3.0179
LP/J m 3.875 0.3176 4.4997 3.2503
MRL/MpJ f 3.375 0.3176 3.9997 2.7503
MRL/MpJ m 3.6714 0.3396 4.3392 3.0036
NOD.B10Sn-H2b/J f 5.75 0.3668 6.4713 5.0287
NOD.B10Sn-H2b/J m 5.5429 0.3396 6.2106 4.8751
NON/ShiLtJ f 5.3625 0.3176 5.9872 4.7378
NON/ShiLtJ m 4.6571 0.3396 5.3249 3.9894
NZO/HlLtJ f 5.5571 0.3396 6.2249 4.8894
NZO/HlLtJ m 4.2333 0.3668 4.9546 3.512
NZW/LacJ f 5.475 0.3176 6.0997 4.8503
NZW/LacJ m 5.975 0.3176 6.5997 5.3503
PL/J f 4.6333 0.5187 5.6534 3.6133
PL/J m 6.92 0.4018 7.7101 6.1299
PWD/PhJ f 6.6875 0.3176 7.3122 6.0628
PWD/PhJ m 4.575 0.3176 5.1997 3.9503
RIIIS/J f 5.6375 0.3176 6.2622 5.0128
RIIIS/J m 5.825 0.3176 6.4497 5.2003
SJL/J f 3.35 0.3668 4.0713 2.6287
SJL/J m 4.175 0.4492 5.0584 3.2916
SM/J f 6.7429 0.3396 7.4106 6.0751
SM/J m 4.5556 0.2995 5.1445 3.9666
SWR/J f 3.9 0.2995 4.4889 3.3111
SWR/J m 3.3714 0.3396 4.0392 2.7036
WSB/EiJ f 1.7714 0.3396 2.4392 1.1036
WSB/EiJ m 1.65 0.6353 2.8993 0.4007


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 4.7 0.2246 5.1417 4.2583
A/J both 4.9052 0.215 5.3281 4.4823
AKR/J both 2.8833 0.4101 3.6898 2.0769
BALB/cByJ both 4.7 0.2246 5.1417 4.2583
BTBR T+ Itpr3tf/J both 4.6464 0.2325 5.1036 4.1892
BUB/BnJ both 4.825 0.232 5.2812 4.3688
C3H/HeJ both 6.2375 0.2325 6.6947 5.7803
C57BL/10J both 6.5214 0.2401 6.9936 6.0492
C57BL/6J both 6.2375 0.2246 6.6792 5.7958
C57BLKS/J both 5.475 0.2246 5.9167 5.0333
C57BR/cdJ both 5.6313 0.2246 6.073 5.1895
C57L/J both 5.1652 0.2325 5.6224 4.708
CBA/J both 6.331 0.2499 6.8224 5.8395
DBA/2J both 5.3298 0.2499 5.8212 4.8383
FVB/NJ both 3.2 0.2246 3.6417 2.7583
KK/HlJ both 6.6562 0.2246 7.098 6.2145
LP/J both 3.7804 0.2325 4.2376 3.3232
MRL/MpJ both 3.5232 0.2325 3.9804 3.066
NOD.B10Sn-H2b/J both 5.6464 0.2499 6.1379 5.1549
NON/ShiLtJ both 5.0098 0.2325 5.467 4.5526
NZO/HlLtJ both 4.8952 0.2499 5.3867 4.4038
NZW/LacJ both 5.725 0.2246 6.1667 5.2833
PL/J both 5.7767 0.3281 6.4218 5.1315
PWD/PhJ both 5.6312 0.2246 6.073 5.1895
RIIIS/J both 5.7313 0.2246 6.173 5.2895
SJL/J both 3.7625 0.29 4.3327 3.1923
SM/J both 5.6492 0.2264 6.0944 5.204
SWR/J both 3.6357 0.2264 4.0809 3.1905
WSB/EiJ both 1.7107 0.3602 2.419 1.0024




  GWAS USING LINEAR MIXED MODELS