Phenotype measure:   Yuan3   HDL_M18

ID, description, units MPD:24473   HDL_M18   HDL cholesterol (plasma HDL)   [mg/dL]  at age 18mo
Data set, strains Yuan3   inbred   29 strains     sex: both     age: 78wks
Procedure lipid profile
Ontology mappings

  STRAIN COMPARISON PLOT
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Yuan3 - HDL cholesterol (plasma HDL) at age 18mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains25 strains
Mean of the strain means81.3   mg/dL 103   mg/dL
Median of the strain means74.2   mg/dL 97.4   mg/dL
SD of the strain means± 25.1 ± 26.5
Coefficient of variation (CV)0.309 0.258
Min–max range of strain means39.7   –   133   mg/dL 59.5   –   155   mg/dL
Mean sample size per strain7.1   mice 6.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 55047.5333 55047.5333 177.515 < 0.0001
strain 23 165779.4838 7207.8036 23.2434 < 0.0001
sex:strain 23 34062.0894 1480.9604 4.7757 < 0.0001
Residuals 283 87758.5109 310.1007


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 133.0 16.3   4 8.16 0.122 118.0, 155.0 2.06
129S1/SvImJ m 145.0 12.5   8 4.42 0.0861 128.0, 162.0 1.58
A/J f 64.1 10.0   8 3.54 0.156 44.8, 76.0 -0.68
BALB/cByJ f 91.9 27.9   8 9.87 0.304 64.1, 156.0 0.42
BALB/cByJ m 113.0 8.35   5 3.74 0.0737 102.0, 123.0 0.38
BTBR T+ Itpr3tf/J f 74.2 9.53   8 3.37 0.128 62.5, 90.7 -0.28
BTBR T+ Itpr3tf/J m 87.1 14.9   5 6.65 0.171 77.7, 113.0 -0.6
BUB/BnJ f 55.3 6.76   8 2.39 0.122 45.5, 63.3 -1.03
BUB/BnJ m 61.4 2.43   6 0.993 0.0396 58.4, 64.2 -1.57
C3H/HeJ f 91.0 17.1   8 6.04 0.188 67.2, 117.0 0.39
C3H/HeJ m 114.0 9.53   7 3.6 0.0837 98.2, 127.0 0.41
C57BL/10J f 61.8 10.2   5 4.56 0.165 48.4, 77.1 -0.78
C57BL/10J m 74.2 0.0   1   0.0 0.0 74.2, 74.2 -1.09
C57BL/6J f 58.2 9.57   7 3.62 0.164 43.2, 75.8 -0.92
C57BL/6J m 94.6 24.5   7 9.25 0.259 51.6, 126.0 -0.32
C57BLKS/J f 46.2 6.98   7 2.64 0.151 35.5, 53.2 -1.4
C57BR/cdJ f 68.4 23.6   8 8.33 0.345 50.4, 124.0 -0.51
C57BR/cdJ m 88.2 12.4   6 5.06 0.141 77.0, 112.0 -0.56
C57L/J f 70.2 21.1   8 7.46 0.301 44.4, 117.0 -0.44
C57L/J m 86.0 8.89   6 3.63 0.103 75.4, 99.4 -0.64
CBA/J f 83.1 11.3   8 4.01 0.136 67.6, 97.5 0.07
CBA/J m 110.0 14.5   6 5.92 0.131 92.8, 129.0 0.26
DBA/2J f 47.3 11.1   7 4.18 0.233 30.4, 61.7 -1.35
DBA/2J m 87.4 9.67   8 3.42 0.111 70.9, 99.0 -0.59
FVB/NJ f 121.0 7.3   8 2.58 0.0604 107.0, 130.0 1.58
KK/HlJ f 104.0 29.1   6 11.9 0.28 81.5, 142.0 0.9
KK/HlJ m 154.0 24.9   7 9.43 0.162 114.0, 183.0 1.92
LP/J f 114.0 16.6   7 6.26 0.145 83.1, 129.0 1.3
LP/J m 116.0 5.99   6 2.44 0.0518 110.0, 123.0 0.49
MRL/MpJ f 98.8 32.6   6 13.3 0.33 58.5, 154.0 0.7
MRL/MpJ m 126.0 24.0   8 8.5 0.19 85.0, 152.0 0.87
NOD.B10Sn-H2b/J f 56.4 8.94   7 3.38 0.159 43.6, 69.2 -0.99
NOD.B10Sn-H2b/J m 96.8 10.9   6 4.47 0.113 87.4, 114.0 -0.23
NON/ShiLtJ f 72.1 11.0   15 2.84 0.153 58.6, 95.6 -0.37
NON/ShiLtJ m 141.0 17.8   7 6.73 0.126 118.0, 170.0 1.43
NZO/HlLtJ f 100.0 71.1   3 41.1 0.708 24.2, 165.0 0.74
NZW/LacJ f 119.0 40.3   8 14.2 0.338 49.3, 168.0 1.5
NZW/LacJ m 155.0 22.8   7 8.63 0.148 112.0, 181.0 1.96
P/J f 117.0 20.1   5 8.98 0.172 97.5, 141.0 1.42
P/J m 94.6 14.6   4 7.31 0.155 78.6, 108.0 -0.32
PL/J f 84.9 18.1   6 7.41 0.214 65.2, 118.0 0.14
PL/J m 107.0 20.1   5 8.97 0.188 86.2, 140.0 0.15
PWD/PhJ f 95.5 13.7   7 5.19 0.144 81.2, 121.0 0.56
PWD/PhJ m 100.0 26.0   8 9.2 0.259 46.1, 135.0 -0.11
RIIIS/J f 65.4 6.1   7 2.3 0.0932 56.9, 74.7 -0.63
RIIIS/J m 59.5 9.07   7 3.43 0.152 45.4, 71.4 -1.64
SJL/J f 39.7 14.8   8 5.24 0.374 22.3, 57.7 -1.65
SJL/J m 69.4 20.1   7 7.58 0.289 33.0, 94.9 -1.27
SM/J f 95.3 18.5   7 6.99 0.194 66.2, 116.0 0.56
SM/J m 82.0 17.6   5 7.89 0.215 66.2, 102.0 -0.79
SWR/J f 59.1 12.0   7 4.53 0.203 37.4, 71.8 -0.88
SWR/J m 97.4 9.56   6 3.9 0.0982 82.5, 107.0 -0.21
WSB/EiJ f 71.0 6.11   8 2.16 0.086 61.9, 80.9 -0.41
WSB/EiJ m 116.0 12.7   6 5.19 0.11 97.5, 131.0 0.49


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 133.25 8.8048 150.5813 115.9187
129S1/SvImJ m 145.375 6.226 157.6301 133.1199
BALB/cByJ f 91.9375 6.226 104.1926 79.6824
BALB/cByJ m 113.4 7.8753 128.9016 97.8984
BTBR T+ Itpr3tf/J f 74.2375 6.226 86.4926 61.9824
BTBR T+ Itpr3tf/J m 87.1 7.8753 102.6016 71.5984
BUB/BnJ f 55.275 6.226 67.5301 43.0199
BUB/BnJ m 61.45 7.1891 75.6009 47.2991
C3H/HeJ f 90.9625 6.226 103.2176 78.7074
C3H/HeJ m 113.8857 6.6558 126.9869 100.7845
C57BL/6J f 58.2286 6.6558 71.3298 45.1274
C57BL/6J m 94.5714 6.6558 107.6726 81.4702
C57BR/cdJ f 68.3625 6.226 80.6176 56.1074
C57BR/cdJ m 88.1833 7.1891 102.3343 74.0324
C57L/J f 70.15 6.226 82.4051 57.8949
C57L/J m 86.0333 7.1891 100.1843 71.8824
CBA/J f 83.0875 6.226 95.3426 70.8324
CBA/J m 110.3833 7.1891 124.5343 96.2324
DBA/2J f 47.3429 6.6558 60.4441 34.2416
DBA/2J m 87.3625 6.226 99.6176 75.1074
KK/HlJ f 103.85 7.1891 118.0009 89.6991
KK/HlJ m 153.5714 6.6558 166.6726 140.4702
LP/J f 113.8714 6.6558 126.9726 100.7702
LP/J m 115.6667 7.1891 129.8176 101.5157
MRL/MpJ f 98.8 7.1891 112.9509 84.6491
MRL/MpJ m 126.4875 6.226 138.7426 114.2324
NOD.B10Sn-H2b/J f 56.3857 6.6558 69.4869 43.2845
NOD.B10Sn-H2b/J m 96.8333 7.1891 110.9843 82.6824
NON/ShiLtJ f 72.0733 4.5468 81.0232 63.1235
NON/ShiLtJ m 141.1429 6.6558 154.2441 128.0416
NZW/LacJ f 119.0875 6.226 131.3426 106.8324
NZW/LacJ m 154.5714 6.6558 167.6726 141.4702
P/J f 116.86 7.8753 132.3616 101.3584
P/J m 94.625 8.8048 111.9563 77.2937
PL/J f 84.9167 7.1891 99.0676 70.7657
PL/J m 106.86 7.8753 122.3616 91.3584
PWD/PhJ f 95.5143 6.6558 108.6155 82.4131
PWD/PhJ m 100.4375 6.226 112.6926 88.1824
RIIIS/J f 65.3714 6.6558 78.4726 52.2702
RIIIS/J m 59.5 6.6558 72.6012 46.3988
SJL/J f 39.6625 6.226 51.9176 27.4074
SJL/J m 69.4143 6.6558 82.5155 56.3131
SM/J f 95.2857 6.6558 108.3869 82.1845
SM/J m 82.0 7.8753 97.5016 66.4984
SWR/J f 59.1286 6.6558 72.2298 46.0274
SWR/J m 97.4333 7.1891 111.5843 83.2824
WSB/EiJ f 70.9625 6.226 83.2176 58.7074
WSB/EiJ m 115.5833 7.1891 129.7343 101.4324


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 139.3125 5.3918 149.9257 128.6993
BALB/cByJ both 102.6688 5.0195 112.5491 92.7884
BTBR T+ Itpr3tf/J both 80.6688 5.0195 90.5491 70.7884
BUB/BnJ both 58.3625 4.7552 67.7225 49.0025
C3H/HeJ both 102.4241 4.5569 111.3939 93.4543
C57BL/6J both 76.4 4.7064 85.664 67.136
C57BR/cdJ both 78.2729 4.7552 87.6329 68.913
C57L/J both 78.0917 4.7552 87.4516 68.7317
CBA/J both 96.7354 4.7552 106.0954 87.3755
DBA/2J both 67.3527 4.5569 76.3225 58.3829
KK/HlJ both 128.7107 4.8986 138.353 119.0685
LP/J both 114.769 4.8986 124.4113 105.1268
MRL/MpJ both 112.6438 4.7552 122.0037 103.2838
NOD.B10Sn-H2b/J both 76.6095 4.8986 86.2518 66.9673
NON/ShiLtJ both 106.6081 4.0303 114.5413 98.6749
NZW/LacJ both 136.8295 4.5569 145.7993 127.8597
P/J both 105.7425 5.9065 117.3687 94.1163
PL/J both 95.8883 5.3316 106.3829 85.3937
PWD/PhJ both 97.9759 4.5569 106.9457 89.0061
RIIIS/J both 62.4357 4.7064 71.6997 53.1718
SJL/J both 54.5384 4.5569 63.5082 45.5686
SM/J both 88.6429 5.1556 98.791 78.4947
SWR/J both 78.281 4.8986 87.9232 68.6387
WSB/EiJ both 93.2729 4.7552 102.6329 83.913




  GWAS USING LINEAR MIXED MODELS