Project measure / variable:   Threadgill1   AST_Rx300

ID, description, units MPD:19471   AST_Rx300   aspartate transaminase (serum AST)   [IU/L]  dose: 300 mg/kg  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   37 strains     sex: m     age: 8-17wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Threadgill1 - aspartate transaminase (serum AST) dose: 300 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested37 strains
Mean of the strain means4465   IU/L
Median of the strain means3852   IU/L
SD of the strain means± 4091
Coefficient of variation (CV)0.916
Min–max range of strain means158   –   21667   IU/L
Mean sample size per strain3.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 36 2017226990.2785 56034083.0633 2.0799 0.0023
Residuals 101 2721012622.7143 26940719.0368


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 8920.0 11521.0   4 5760.0 1.29 79.0, 24320.0 1.09
A/J m 3395.0 6504.0   4 3252.0 1.92 110.0, 13150.0 -0.26
AKR/J m 5754.0 7348.0   7 2777.0 1.28 44.0, 16000.0 0.32
B6C3F1/J m 21667.0 12606.0   3 7278.0 0.582 8850.0, 34050.0 4.21
BALB/cByJ m 4146.0 2905.0   4 1453.0 0.701 85.0, 6640.0 -0.08
BTBR T+ Itpr3tf/J m 2178.0 4214.0   4 2107.0 1.93 68.0, 8500.0 -0.56
BUB/BnJ m 1296.0 943.0   3 544.0 0.728 222.0, 1990.0 -0.77
C3H/HeJ m 12255.0 6408.0   4 3204.0 0.523 5200.0, 18320.0 1.9
C57BL/10J m 7060.0 7898.0   4 3949.0 1.12 72.0, 17920.0 0.63
C57BL/6J m 3099.0 3351.0   4 1676.0 1.08 84.0, 6000.0 -0.33
C57BLKS/J m 1804.0 3318.0   4 1659.0 1.84 54.0, 6780.0 -0.65
C57BR/cdJ m 7884.0 7053.0   4 3527.0 0.895 3715.0, 18375.0 0.84
C57L/J m 1180.0 839.0   3 484.0 0.711 250.0, 1880.0 -0.8
CAST/EiJ m 158.0 46.0   2   32.5 0.292 125.0, 190.0 -1.05
CBA/J m 9752.0 7660.0   4 3830.0 0.785 1610.0, 18350.0 1.29
CZECHII/EiJ m 692.0 781.0   3 451.0 1.13 112.0, 1580.0 -0.92
DBA/2J m 7573.0 4039.0   6 1649.0 0.533 691.0, 12520.0 0.76
FVB/NJ m 4136.0 3602.0   3 2080.0 0.871 98.0, 7020.0 -0.08
JF1/MsJ m 5632.0 3530.0   4 1765.0 0.627 1268.0, 8500.0 0.29
KK/HlJ m 3932.0 774.0   3 447.0 0.197 3405.0, 4820.0 -0.13
LP/J m 166.0 82.5   3 47.6 0.498 107.0, 260.0 -1.05
MA/MyJ m 3972.0 4479.0   4 2240.0 1.13 123.0, 8560.0 -0.12
MSM/MsJ m 2560.0 2233.0   3 1289.0 0.872 1010.0, 5120.0 -0.47
NOD/ShiLtJ m 3395.0 1980.0   4 990.0 0.583 880.0, 5090.0 -0.26
NON/ShiLtJ m 418.0 136.0   4 67.8 0.324 260.0, 585.0 -0.99
NZO/HlLtJ m 600.0 994.0   4 497.0 1.66 80.0, 2090.0 -0.94
NZW/LacJ m 2845.0 2495.0   4 1248.0 0.877 1080.0, 6500.0 -0.4
PERA/EiJ m 3577.0 5043.0   3 2911.0 1.41 265.0, 9380.0 -0.22
P/J m 7950.0 5849.0   4 2925.0 0.736 1625.0, 13375.0 0.85
PL/J m 1217.0 871.0   3 503.0 0.716 220.0, 1830.0 -0.79
PWD/PhJ m 3852.0 3469.0   3 2003.0 0.901 440.0, 7375.0 -0.15
RIIIS/J m 4085.0 4484.0   4 2242.0 1.1 366.0, 10475.0 -0.09
SEA/GnJ m 6053.0 5329.0   3 3077.0 0.88 108.0, 10400.0 0.39
SJL/J m 2070.0 2368.0   4 1184.0 1.14 122.0, 5230.0 -0.59
SM/J m 3976.0 7629.0   4 3815.0 1.92 71.0, 15420.0 -0.12
SWR/J m 1735.0 1675.0   3 967.0 0.966 114.0, 3460.0 -0.67
WSB/EiJ m 4215.0 2938.0   4 1469.0 0.697 224.0, 6700.0 -0.06


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 8920.5 2595.2225 14068.7233 3772.2767
A/J m 3395.0 2595.2225 8543.2233 0.0
AKR/J m 5754.4286 1961.8038 9646.1196 1862.7376
B6C3F1/J m 21666.6667 2996.7048 27611.3229 15722.0104
BALB/cByJ m 4146.25 2595.2225 9294.4733 0.0
BTBR T+ Itpr3tf/J m 2178.5 2595.2225 7326.7233 0.0
BUB/BnJ m 1295.6667 2996.7048 7240.3229 0.0
C3H/HeJ m 12255.0 2595.2225 17403.2233 7106.7767
C57BL/10J m 7060.5 2595.2225 12208.7233 1912.2767
C57BL/6J m 3099.0 2595.2225 8247.2233 0.0
C57BLKS/J m 1804.0 2595.2225 6952.2233 0.0
C57BR/cdJ m 7883.75 2595.2225 13031.9733 2735.5267
C57L/J m 1180.0 2996.7048 7124.6562 0.0
CAST/EiJ m 157.5 3670.1988 7438.1872 0.0
CBA/J m 9752.5 2595.2225 14900.7233 4604.2767
CZECHII/EiJ m 691.6667 2996.7048 6636.3229 0.0
DBA/2J m 7572.6667 2118.9903 11776.1734 3369.1599
FVB/NJ m 4136.0 2996.7048 10080.6562 0.0
JF1/MsJ m 5632.0 2595.2225 10780.2233 483.7767
KK/HlJ m 3931.6667 2996.7048 9876.3229 0.0
LP/J m 165.6667 2996.7048 6110.3229 0.0
MA/MyJ m 3972.0 2595.2225 9120.2233 0.0
MSM/MsJ m 2560.0 2996.7048 8504.6562 0.0
NOD/ShiLtJ m 3395.0 2595.2225 8543.2233 0.0
NON/ShiLtJ m 418.0 2595.2225 5566.2233 0.0
NZO/HlLtJ m 599.5 2595.2225 5747.7233 0.0
NZW/LacJ m 2845.25 2595.2225 7993.4733 0.0
PERA/EiJ m 3576.6667 2996.7048 9521.3229 0.0
P/J m 7950.0 2595.2225 13098.2233 2801.7767
PL/J m 1216.6667 2996.7048 7161.3229 0.0
PWD/PhJ m 3851.6667 2996.7048 9796.3229 0.0
RIIIS/J m 4085.25 2595.2225 9233.4733 0.0
SEA/GnJ m 6052.6667 2996.7048 11997.3229 108.0104
SJL/J m 2070.5 2595.2225 7218.7233 0.0
SM/J m 3976.25 2595.2225 9124.4733 0.0
SWR/J m 1734.6667 2996.7048 7679.3229 0.0
WSB/EiJ m 4214.75 2595.2225 9362.9733 0.0




  GWAS USING LINEAR MIXED MODELS