Project measure / variable:   Threadgill1   AST_Rx200

ID, description, units MPD:19441   AST_Rx200   aspartate transaminase (serum AST)   [IU/L]  dose: 200 mg/kg  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   8 strains     sex: m     age: 8-17wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Threadgill1 - aspartate transaminase (serum AST) dose: 200 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested8 strains
Mean of the strain means8005   IU/L
Median of the strain means9408   IU/L
SD of the strain means± 7082
Coefficient of variation (CV)0.885
Min–max range of strain means95.5   –   18417   IU/L
Mean sample size per strain3.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 7 1174900103.9405 167842871.9915 6.2175 0.0006
Residuals 20 539905496.1667 26995274.8083


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6C3F1/J m 8848.0 10491.0   4 5245.0 1.19 101.0, 23120.0 0.12
C3H/HeJ m 95.5 17.7   4 8.86 0.185 70.0, 108.0 -1.12
C57BL/10J m 14617.0 3149.0   3 1818.0 0.215 11150.0, 17300.0 0.93
CBA/J m 18417.0 4688.0   3 2707.0 0.255 13350.0, 22600.0 1.47
DBA/2J m 9969.0 1573.0   4 786.0 0.158 8175.0, 11850.0 0.28
LP/J m 330.0 175.0   3 101.0 0.53 129.0, 448.0 -1.08
NOD/ShiLtJ m 228.0 255.0   4 128.0 1.12 95.0, 611.0 -1.1
SM/J m 11533.0 8315.0   3 4801.0 0.721 2050.0, 17575.0 0.5


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6C3F1/J m 8847.75 2597.8489 14266.7678 3428.7322
C3H/HeJ m 95.5 2597.8489 5514.5178 0.0
C57BL/10J m 14616.6667 2999.7375 20874.0094 8359.3239
CBA/J m 18416.6667 2999.7375 24674.0094 12159.3239
DBA/2J m 9968.75 2597.8489 15387.7678 4549.7322
LP/J m 329.6667 2999.7375 6587.0094 0.0
NOD/ShiLtJ m 228.5 2597.8489 5647.5178 0.0
SM/J m 11533.3333 2999.7375 17790.6761 5275.9906




  GWAS USING LINEAR MIXED MODELS