Project measure / variable:   Crabbe4   gripEtOH30

ID, description, units MPD:19107   gripEtOH30   grip strength test: peak force applied   [g]  30 min after ethanol  
ethanol study
Data set, strains Crabbe4   inbred   21 strains     sex: both     age: 7-12wks
Procedure grip strength
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  STRAIN COMPARISON PLOT
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Crabbe4 - grip strength test: peak force applied 30 min after ethanol



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested21 strains21 strains
Mean of the strain means69.7   g 71.1   g
Median of the strain means74.0   g 76.5   g
SD of the strain means± 19.2 ± 25.8
Coefficient of variation (CV)0.276 0.363
Min–max range of strain means32.8   –   98.0   g 22.1   –   122   g
Mean sample size per strain6.5   mice 5.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 117.0443 117.0443 0.2246 0.6361
strain 20 82033.7752 4101.6888 7.8696 < 0.0001
sex:strain 20 40729.4057 2036.4703 3.9072 < 0.0001
Residuals 216 112580.8013 521.2074


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 81.2 10.8   6 4.41 0.133 65.7, 94.5 0.6
129S1/SvImJ m 59.3 20.8   6 8.5 0.351 21.7, 81.6 -0.46
A/J f 89.0 18.5   6 7.54 0.207 56.9, 111.0 1.0
A/J m 96.6 16.4   6 6.69 0.17 70.4, 113.0 0.99
AKR/J f 72.9 14.6   6 5.96 0.2 59.4, 94.5 0.17
AKR/J m 68.2 16.6   6 6.76 0.243 44.8, 94.5 -0.11
BALB/cByJ f 71.0 21.3   6 8.7 0.3 40.9, 95.0 0.07
BALB/cByJ m 89.5 21.7   6 8.86 0.242 58.0, 111.0 0.71
BTBR T+ Itpr3tf/J f 48.7 27.5   6 11.2 0.565 -1.09
BTBR T+ Itpr3tf/J m 67.0 18.1   5 8.08 0.27 49.0, 91.5 -0.16
C3H/HeJ f 32.8 39.1   6 16.0 1.19 -1.92
C3H/HeJ m 110.0 36.1   6 14.7 0.327 69.4, 158.0 1.51
C57BL/6J f 74.0 15.2   12 4.38 0.205 46.0, 100.0 0.22
C57BL/6J m 85.9 18.4   6 7.5 0.214 63.7, 111.0 0.57
C57L/J f 98.0 25.1   6 10.3 0.256 69.8, 136.0 1.47
C57L/J m 73.1 17.8   6 7.26 0.243 55.0, 100.0 0.08
C58/J f 89.4 12.4   4 6.2 0.139 74.4, 104.0 1.03
C58/J m 65.4 50.9   6 20.8 0.779 -0.22
CAST/EiJ f 64.4 20.7   6 8.45 0.322 31.9, 89.6 -0.28
CAST/EiJ m 76.9 13.2   5 5.9 0.172 61.0, 96.0 0.22
DBA/2J f 74.0 17.3   12 5.0 0.234 44.5, 96.4 0.22
DBA/2J m 76.5 14.2   6 5.79 0.185 58.3, 90.0 0.21
FVB/NJ f 85.2 39.6   6 16.2 0.465 6.2, 113.0 0.81
FVB/NJ m 83.3 18.3   6 7.47 0.22 65.9, 117.0 0.47
MOLF/EiJ f 48.7 24.0   7 9.08 0.494 22.2, 92.1 -1.09
MOLF/EiJ m 31.6 23.3   6 9.51 0.738 17.5, 78.4 -1.53
NOD/ShiLtJ f 74.1 36.2   6 14.8 0.489 15.7, 120.0 0.23
NOD/ShiLtJ m 122.0 38.0   6 15.5 0.311 69.9, 163.0 1.97
NZB/BlNJ f 41.2 14.9   6 6.09 0.362 22.1, 66.6 -1.48
NZB/BlNJ m 28.7 19.9   6 8.11 0.692 -1.64
PERA/EiJ f 95.8 10.9   8 3.85 0.114 79.8, 111.0 1.36
PERA/EiJ m 82.6 30.4   4 15.2 0.368 45.4, 108.0 0.45
PL/J f 63.1 10.7   6 4.37 0.17 53.1, 80.7 -0.34
PL/J m 22.1 22.6   6 9.22 1.02 -1.9
SJL/J f 84.9 19.7   6 8.03 0.232 53.1, 105.0 0.79
SJL/J m 85.6 23.1   5 10.3 0.27 49.9, 114.0 0.56
SM/J f 40.3 2.97   6 1.21 0.0736 37.4, 45.8 -1.53
SM/J m 54.5 15.0   6 6.13 0.276 35.1, 71.4 -0.64
SPRET/EiJ f 52.3 19.7   6 8.02 0.376 34.4, 75.7 -0.91
SPRET/EiJ m 36.9 23.1   4 11.5 0.627 19.2, 69.7 -1.33
SWR/J f 82.8 9.08   6 3.71 0.11 73.8, 93.6 0.68
SWR/J m 77.4 22.3   6 9.11 0.288 42.7, 101.0 0.24


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 81.25 9.3203 99.6204 62.8796
129S1/SvImJ m 59.3167 9.3203 77.687 40.9463
A/J f 89.05 9.3203 107.4204 70.6796
A/J m 96.65 9.3203 115.0204 78.2796
AKR/J f 72.9333 9.3203 91.3037 54.563
AKR/J m 68.2167 9.3203 86.587 49.8463
BALB/cByJ f 70.9833 9.3203 89.3537 52.613
BALB/cByJ m 89.5167 9.3203 107.887 71.1463
BTBR T+ Itpr3tf/J f 48.6667 9.3203 67.037 30.2963
BTBR T+ Itpr3tf/J m 66.98 10.2099 87.1037 46.8563
C3H/HeJ f 32.7833 9.3203 51.1537 14.413
C3H/HeJ m 110.1833 9.3203 128.5537 91.813
C57BL/6J f 74.0167 6.5904 87.0065 61.0269
C57BL/6J m 85.9 9.3203 104.2704 67.5296
C57L/J f 97.95 9.3203 116.3204 79.5796
C57L/J m 73.0667 9.3203 91.437 54.6963
C58/J f 89.375 11.415 111.874 66.876
C58/J m 65.35 9.3203 83.7204 46.9796
CAST/EiJ f 64.35 9.3203 82.7204 45.9796
CAST/EiJ m 76.9 10.2099 97.0237 56.7763
DBA/2J f 73.95 6.5904 86.9398 60.9602
DBA/2J m 76.5167 9.3203 94.887 58.1463
FVB/NJ f 85.15 9.3203 103.5204 66.7796
FVB/NJ m 83.3167 9.3203 101.687 64.9463
MOLF/EiJ f 48.6571 8.6289 65.6648 31.6495
MOLF/EiJ m 31.5667 9.3203 49.937 13.1963
NOD/ShiLtJ f 74.1333 9.3203 92.5037 55.763
NOD/ShiLtJ m 122.15 9.3203 140.5204 103.7796
NZB/BlNJ f 41.1833 9.3203 59.5537 22.813
NZB/BlNJ m 28.7 9.3203 47.0704 10.3296
PERA/EiJ f 95.825 8.0716 111.7342 79.9158
PERA/EiJ m 82.65 11.415 105.149 60.151
PL/J f 63.0833 9.3203 81.4537 44.713
PL/J m 22.1333 9.3203 40.5037 3.763
SJL/J f 84.9333 9.3203 103.3037 66.563
SJL/J m 85.64 10.2099 105.7637 65.5163
SM/J f 40.3333 9.3203 58.7037 21.963
SM/J m 54.45 9.3203 72.8204 36.0796
SPRET/EiJ f 52.3 9.3203 70.6704 33.9296
SPRET/EiJ m 36.85 11.415 59.349 14.351
SWR/J f 82.75 9.3203 101.1204 64.3796
SWR/J m 77.35 9.3203 95.7204 58.9796


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 70.2833 6.5904 83.2731 57.2935
A/J both 92.85 6.5904 105.8398 79.8602
AKR/J both 70.575 6.5904 83.5648 57.5852
BALB/cByJ both 80.25 6.5904 93.2398 67.2602
BTBR T+ Itpr3tf/J both 57.8233 6.9121 71.4472 44.1995
C3H/HeJ both 71.4833 6.5904 84.4731 58.4935
C57BL/6J both 79.9583 5.7075 91.2078 68.7088
C57L/J both 85.5083 6.5904 98.4981 72.5185
C58/J both 77.3625 7.3683 91.8856 62.8394
CAST/EiJ both 70.625 6.9121 84.2488 57.0012
DBA/2J both 75.2333 5.7075 86.4828 63.9838
FVB/NJ both 84.2333 6.5904 97.2231 71.2435
MOLF/EiJ both 40.1119 6.3507 52.6292 27.5946
NOD/ShiLtJ both 98.1417 6.5904 111.1315 85.1519
NZB/BlNJ both 34.9417 6.5904 47.9315 21.9519
PERA/EiJ both 89.2375 6.9902 103.0153 75.4597
PL/J both 42.6083 6.5904 55.5981 29.6185
SJL/J both 85.2867 6.9121 98.9105 71.6628
SM/J both 47.3917 6.5904 60.3815 34.4019
SPRET/EiJ both 44.575 7.3683 59.0981 30.0519
SWR/J both 80.05 6.5904 93.0398 67.0602




  GWAS USING LINEAR MIXED MODELS