Project measure / variable:   Cheverud1   leptin_ctrl

ID, description, units MPD:17841   leptin_ctrl   leptin (serum)   [pg/mL]  control diet  
high-fat diet study
Data set, strains Cheverud1   LGXSM w/par   10 strains     sex: both     age: 20-30wks
Procedure hormone quantification
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  STRAIN COMPARISON PLOT
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Cheverud1 - leptin (serum) control diet



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains8 strains
Mean of the strain means22.2   pg/mL 22.2   pg/mL
Median of the strain means18.0   pg/mL 29.2   pg/mL
SD of the strain means± 14.3 ± 12.9
Coefficient of variation (CV)0.645 0.580
Min–max range of strain means6.07   –   54.0   pg/mL 2.81   –   35.9   pg/mL
Mean sample size per strain4.7   mice 7.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 634.8528 634.8528 4.3703 0.0402
strain 6 10070.168 1678.3613 11.5539 < 0.0001
sex:strain 6 4532.3967 755.3994 5.2002 0.0002
Residuals 70 10168.4545 145.2636


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
LGXSM10 f 34.3 10.5   3 6.07 0.306 22.2, 40.5 0.85
LGXSM10 m 5.19 6.91   7 2.61 1.33 1.32, 20.5 -1.32
LGXSM15 f 12.7 9.19   8 3.25 0.724 4.6, 28.9 -0.66
LGXSM15 m 14.0 11.4   9 3.79 0.812 1.9, 31.6 -0.64
LGXSM18 f 18.0 9.77   7 3.69 0.542 5.62, 35.7 -0.29
LGXSM18 m 28.5 11.9   8 4.21 0.418 3.58, 42.5 0.49
LGXSM19 f 19.8 14.1   4 7.04 0.712 7.58, 33.1 -0.16
LGXSM19 m 30.6 5.8   7 2.19 0.19 26.1, 42.7 0.65
LGXSM22 f 54.0 21.1   8 7.45 0.391 13.6, 78.9 2.23
LGXSM22 m 29.9 14.5   6 5.93 0.486 7.36, 45.7 0.6
LGXSM23 m 35.9 11.6   12 3.34 0.322 1.0, 44.8 1.06
LGXSM33 f 24.0 17.4   4 8.72 0.728 5.12, 40.3 0.13
LGXSM33 m 30.8 7.68   5 3.43 0.25 19.3, 38.9 0.67
LGXSM38 f 14.1 10.3   4 5.16 0.73 1.4, 23.2 -0.56
LGXSM38 m 2.81 3.63   4 1.81 1.29 1.0, 8.26 -1.5
LGXSM45 f 6.07 1.05   3 0.607 0.173 5.26, 7.26 -1.13
LGXSM5 f 16.4 10.6   3 6.11 0.644 4.22, 22.7 -0.4


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
LGXSM10 f 34.3333 6.9585 48.2117 20.455
LGXSM10 m 5.1943 4.5554 14.2798 0.0
LGXSM15 f 12.6937 4.2612 21.1925 4.195
LGXSM15 m 14.0044 4.0175 22.0171 5.9918
LGXSM18 f 18.0143 4.5554 27.0998 8.9288
LGXSM18 m 28.51 4.2612 37.0087 20.0113
LGXSM19 f 19.7775 6.0263 31.7965 7.7585
LGXSM19 m 30.5571 4.5554 39.6427 21.4716
LGXSM22 f 53.95 4.2612 62.4487 45.4513
LGXSM22 m 29.8933 4.9204 39.7068 20.0799
LGXSM33 f 23.955 6.0263 35.974 11.936
LGXSM33 m 30.76 5.3901 41.5101 20.0099
LGXSM38 f 14.125 6.0263 26.144 2.106
LGXSM38 m 2.815 6.0263 14.834 0.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
LGXSM10 both 19.7638 4.1585 28.0577 11.4699
LGXSM15 both 13.3491 2.9282 19.1893 7.5089
LGXSM18 both 23.2621 3.1189 29.4826 17.0417
LGXSM19 both 25.1673 3.7772 32.7006 17.634
LGXSM22 both 41.9217 3.2546 48.4127 35.4307
LGXSM33 both 27.3575 4.0425 35.4201 19.2949
LGXSM38 both 8.47 4.2612 16.9687 0.0




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA