Project measure / variable:   Crabbe3   ARR1_chg_20rpm

ID, description, units MPD:15842   ARR1_chg_20rpm   latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1)   [s]  difference  
ethanol study
Data set, strains Crabbe3   inbred   8 strains     sex: both     age: 9-17wks
Procedure rotarod
Ontology mappings

  STRAIN COMPARISON PLOT
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Crabbe3 - latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1) difference



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means-0.183   s -2.20   s
Median of the strain means3.53   s -2.50   s
SD of the strain means± 12.0 ± 18.8
Coefficient of variation (CV)-65.9 -8.58
Min–max range of strain means-21.6   –   11.6   s -39.9   –   20.9   s
Mean sample size per strain5.9   mice 5.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2.1283 2.1283 0.0055 0.9409
strain 7 10922.1411 1560.3059 4.056 0.0009
sex:strain 7 2779.5505 397.0786 1.0322 0.4166
Residuals 71 27313.277 384.694


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f -21.6 13.6   6 5.56 -0.631 -42.6, -7.1 -1.78
129S1/SvImJ m -4.5 21.2   6 8.64 -4.7 -31.8, 21.1 -0.12
A/J f 3.33 14.8   6 6.03 4.43 -16.3, 22.6 0.29
A/J m -2.35 18.0   6 7.34 -7.65 -18.3, 28.2 -0.01
BALB/cByJ f 11.6 23.6   6 9.62 2.04 -19.0, 38.2 0.98
BALB/cByJ m 20.9 5.94   4 2.97 0.284 16.3, 29.0 1.23
BTBR T+ Itpr3tf/J f -15.5 38.7   5 17.3 -2.49 -59.5, 22.0 -1.27
BTBR T+ Itpr3tf/J m -39.9 30.0   2   21.2 -0.751 -61.1, -18.7 -2.0
C3H/HeJ f 1.48 22.2   6 9.05 14.9 -34.6, 32.1 0.14
C3H/HeJ m -11.8 16.0   6 6.54 -1.36 -30.6, 9.9 -0.51
C57BL/6J f 4.3 21.2   6 8.65 4.93 -32.6, 31.3 0.37
C57BL/6J m -2.65 16.1   4 8.04 -6.07 -18.6, 18.8 -0.02
DBA/2J f 3.73 17.7   6 7.24 4.75 -16.7, 30.6 0.33
DBA/2J m 5.63 17.2   6 7.01 3.05 -12.7, 26.9 0.42
FVB/NJ f 11.2 7.84   6 3.2 0.701 -0.1, 18.8 0.95
FVB/NJ m 17.1 17.7   6 7.21 1.03 -4.3, 37.8 1.02


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f -21.5667 8.0072 -5.6007 -37.5326
129S1/SvImJ m -4.5 8.0072 11.466 -20.466
A/J f 3.3333 8.0072 19.2993 -12.6326
A/J m -2.35 8.0072 13.616 -18.316
BALB/cByJ f 11.55 8.0072 27.516 -4.416
BALB/cByJ m 20.9 9.8068 40.4542 1.3458
BTBR T+ Itpr3tf/J f -15.54 8.7715 1.9498 -33.0298
BTBR T+ Itpr3tf/J m -39.9 13.8689 -12.2462 -67.5538
C3H/HeJ f 1.4833 8.0072 17.4493 -14.4826
C3H/HeJ m -11.75 8.0072 4.216 -27.716
C57BL/6J f 4.3 8.0072 20.266 -11.666
C57BL/6J m -2.65 9.8068 16.9042 -22.2042
DBA/2J f 3.7333 8.0072 19.6993 -12.2326
DBA/2J m 5.6333 8.0072 21.5993 -10.3326
FVB/NJ f 11.1833 8.0072 27.1493 -4.7826
FVB/NJ m 17.1 8.0072 33.066 1.134


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both -13.0333 5.662 -1.7437 -24.323
A/J both 0.4917 5.662 11.7813 -10.798
BALB/cByJ both 16.225 6.3303 28.8472 3.6028
BTBR T+ Itpr3tf/J both -27.72 8.205 -11.3598 -44.0802
C3H/HeJ both -5.1333 5.662 6.1563 -16.423
C57BL/6J both 0.825 6.3303 13.4472 -11.7972
DBA/2J both 4.6833 5.662 15.973 -6.6063
FVB/NJ both 14.1417 5.662 25.4313 2.852




  GWAS USING LINEAR MIXED MODELS