Project measure / variable:   Crabbe3   FS_10rpm_EtOH_2

ID, description, units MPD:15821   FS_10rpm_EtOH_2   latency to fall, fixed speed 10 rpm rotarod   [s]  dose: 2 g/kg i.p.  
ethanol study
Data set, strains Crabbe3   inbred   8 strains     sex: both     age: 9-17wks
Procedure rotarod
Ontology mappings

  STRAIN COMPARISON PLOT
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Crabbe3 - latency to fall, fixed speed 10 rpm rotarod dose: 2 g/kg i.p.



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains7 strains
Mean of the strain means77.9   s 58.4   s
Median of the strain means67.8   s 61.0   s
SD of the strain means± 34.4 ± 7.04
Coefficient of variation (CV)0.442 0.121
Min–max range of strain means45.5   –   144   s 46.8   –   66.8   s
Mean sample size per strain3.1   mice 2.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4875.6443 4875.6443 3.144 0.0884
strain 5 18656.3683 3731.2737 2.4061 0.0652
sex:strain 5 10505.9268 2101.1854 1.3549 0.2746
Residuals 25 38769.4017 1550.7761


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 49.5 24.6   4 12.3 0.498 13.8, 66.3 -0.82
129S1/SvImJ m 61.0 55.9   4 27.9 0.916 22.9, 144.0 0.37
B6D2F1/J f 54.0 14.5   2   10.2 0.268 43.8, 64.3 -0.69
B6D2F1/J m 46.8 14.5   2   10.2 0.31 36.5, 57.0 -1.65
BALB/cByJ f 144.0 41.9   4 20.9 0.291 106.0, 180.0 1.92
BALB/cByJ m 63.2 13.0   2   9.2 0.206 54.0, 72.4 0.68
BTBR T+ Itpr3tf/J f 56.1 7.11   3 4.11 0.127 48.1, 61.7 -0.63
C3H/HeJ f 45.5 17.3   4 8.66 0.38 32.6, 71.0 -0.94
C3H/HeJ m 66.8 38.9   2   27.5 0.582 39.3, 94.3 1.19
C57BL/6J f 85.5 65.6   4 32.8 0.768 34.5, 180.0 0.22
C57BL/6J m 53.9 10.0   3 5.78 0.186 43.0, 62.7 -0.64
DBA/2J f 79.6 0.0   1   0.0 0.0 79.6, 79.6 0.05
DBA/2J m 54.0 2.05   2   1.45 0.0379 52.6, 55.5 -0.63
FVB/NJ f 109.0 53.7   3 31.0 0.493 50.4, 156.0 0.9
FVB/NJ m 63.2 15.0   3 8.66 0.237 49.8, 79.4 0.68


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 49.475 19.6899 90.0272 8.9228
129S1/SvImJ m 60.95 19.6899 101.5022 20.3978
B6D2F1/J f 54.05 27.8458 111.3995 0.0
B6D2F1/J m 46.75 27.8458 104.0995 0.0
BALB/cByJ f 143.75 19.6899 184.3022 103.1978
BALB/cByJ m 63.2 27.8458 120.5495 5.8505
C3H/HeJ f 45.55 19.6899 86.1022 4.9978
C3H/HeJ m 66.8 27.8458 124.1495 9.4505
C57BL/6J f 85.475 19.6899 126.0272 44.9228
C57BL/6J m 53.8667 22.736 100.6923 7.041
FVB/NJ f 108.8 22.736 155.6257 61.9743
FVB/NJ m 63.2 22.736 110.0257 16.3743


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 55.2125 13.9229 83.8872 26.5378
B6D2F1/J both 50.4 19.6899 90.9522 9.8478
BALB/cByJ both 103.475 17.052 138.5942 68.3558
C3H/HeJ both 56.175 17.052 91.2942 21.0558
C57BL/6J both 69.6708 15.0384 100.6431 38.6986
FVB/NJ both 86.0 16.0768 119.1107 52.8893




  GWAS USING LINEAR MIXED MODELS