Project measure / variable:   Project1148   min_depression

ID, description, units MPD:118090   min_depression   minimum respiratory depression (breath rate, percentage of baseline), post injection   [%]  
morphine study
Data set, strains Project1148   inbred w/CC8   8 strains     sex: both     age: 8 to 24 weeks
Procedure monitoring system
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  STRAIN COMPARISON PLOT
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Project1148 - minimum respiratory depression (breath rate, percentage of baseline), post injection



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means60.98   % 59.83   %
Median of the strain means59.59   % 58.34   %
SD of the strain means± 6.487 ± 10.063
Coefficient of variation (CV)0.1064 0.1682
Min–max range of strain means54.0   –   71.83   % 49.167   –   76.83   %
Mean sample size per strain6.0   mice 6.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 31.5104 31.5104 0.4433 0.5075
strain 7 5342.0729 763.1533 10.7357 < 0.0001
sex:strain 7 680.7396 97.2485 1.3681 0.2303
Residuals 80 5686.8333 71.0854


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 54.0 3.7417   6 1.5275 0.0693 48.0, 59.0 -1.08
129S1/SvImJ m 53.17 2.0412   6 0.83333 0.0384 50.0, 56.0 -0.66
A/J f 69.0 5.4037   6 2.2061 0.0783 63.0, 79.0 1.24
A/J m 66.83 6.9976   6 2.8568 0.1047 59.0, 77.0 0.7
C57BL/6J f 59.5 4.6797   6 1.9105 0.0787 51.0, 64.0 -0.23
C57BL/6J m 49.167 4.3089   6 1.7591 0.0876 43.0, 55.0 -1.06
CAST/EiJ f 62.17 7.7309   6 3.1561 0.1244 54.0, 74.0 0.18
CAST/EiJ m 63.5 5.2058   6 2.1252 0.082 57.0, 70.0 0.36
NOD/ShiLtJ f 57.5 17.729   6 7.2376 0.3083 38.0, 90.0 -0.54
NOD/ShiLtJ m 51.5 2.6646   6 1.0878 0.0517 49.0, 56.0 -0.83
NZO/HlLtJ f 59.67 4.4572   6 1.8196 0.0747 55.0, 68.0 -0.2
NZO/HlLtJ m 66.83 12.123   6 4.9492 0.1814 56.0, 89.0 0.7
PWK/PhJ f 71.83 12.513   6 5.1083 0.1742 58.0, 92.0 1.67
PWK/PhJ m 76.83 12.875   6 5.2562 0.1676 60.0, 90.0 1.69
WSB/EiJ f 54.17 3.8166   6 1.5581 0.0705 49.0, 59.0 -1.05
WSB/EiJ m 50.83 9.411   6 3.842 0.1851 36.0, 63.0 -0.89


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ 1 62.1666666667 3.4420298436 69.0165243533 55.31680898
129S1/SvImJ 2 63.5 3.4420298436 70.3498576867 56.6501423133
A/J 1 71.8333333333 3.4420298436 78.68319102 64.9834756467
A/J 2 76.8333333333 3.4420298436 83.68319102 69.9834756467
BALB/cJ 1 54.0 3.4420298436 60.8498576867 47.1501423133
BALB/cJ 2 53.1666666667 3.4420298436 60.0165243533 46.31680898
BTBR T+ Itpr3tf/J 1 59.6666666667 3.4420298436 66.5165243533 52.81680898
BTBR T+ Itpr3tf/J 2 66.8333333333 3.4420298436 73.68319102 59.9834756467
C3H/HeJ 1 69.0 3.4420298436 75.8498576867 62.1501423133
C3H/HeJ 2 66.8333333333 3.4420298436 73.68319102 59.9834756467
C57BL/6J 1 54.1666666667 3.4420298436 61.0165243533 47.31680898
C57BL/6J 2 50.8333333333 3.4420298436 57.68319102 43.9834756467
CAST/EiJ 1 57.5 3.4420298436 64.3498576867 50.6501423133
CAST/EiJ 2 51.5 3.4420298436 58.3498576867 44.6501423133
DBA/2J 1 59.5 3.4420298436 66.3498576867 52.6501423133
DBA/2J 2 49.1666666667 3.4420298436 56.0165243533 42.31680898


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 62.8333333333 2.4338826435 67.6769141537 57.9897525129
A/J both 74.3333333333 2.4338826435 79.1769141537 69.4897525129
BALB/cJ both 53.5833333333 2.4338826435 58.4269141537 48.7397525129
BTBR T+ Itpr3tf/J both 63.25 2.4338826435 68.0935808204 58.4064191796
C3H/HeJ both 67.9166666667 2.4338826435 72.7602474871 63.0730858463
C57BL/6J both 52.5 2.4338826435 57.3435808204 47.6564191796
CAST/EiJ both 54.5 2.4338826435 59.3435808204 49.6564191796
DBA/2J both 54.3333333333 2.4338826435 59.1769141537 49.4897525129




  GWAS USING LINEAR MIXED MODELS