Project measure / variable:   Auwerx2   hdl_HFD

ID, description, units MPD:114688   hdl_HFD   plasma HDL amount   [mmol/L]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 21wks
Procedure lipid profile
Ontology mappings

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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma HDL amount HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means2.5781   mmol/L 3.1906   mmol/L
Median of the strain means2.3478   mmol/L 3.1654   mmol/L
SD of the strain means± 0.98182 ± 1.1116
Coefficient of variation (CV)0.3808 0.3484
Min–max range of strain means1.299   –   4.3948   mmol/L 1.887   –   4.696   mmol/L
Mean sample size per strain4.9   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5.1787 5.1787 42.7665 < 0.0001
strain 7 34.9838 4.9977 41.2717 < 0.0001
sex:strain 7 7.8549 1.1221 9.2667 < 0.0001
Residuals 56 6.7812 0.1211


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3.881 0.44976   5 0.20114 0.1159 3.36, 4.376 1.33
129S1/SvImJ m 4.3285 0.02051   2   0.0145 0.0047 4.314, 4.343 1.02
A/J f 2.1212 0.15562   4 0.07781 0.0734 1.927, 2.298 -0.47
A/J m 2.446 0.32747   5 0.14645 0.1339 2.173, 2.98 -0.67
C57BL/6J f 2.428 0.27751   3 0.16022 0.1143 2.152, 2.707 -0.15
C57BL/6J m 4.539 0.54788   4 0.27394 0.1207 4.105, 5.341 1.21
CAST/EiJ f 1.9014 0.16807   5 0.07516 0.0884 1.691, 2.073 -0.69
CAST/EiJ m 1.923 0.20082   2   0.142 0.1044 1.781, 2.065 -1.14
DBA/2J f 2.0392 0.27754   5 0.12412 0.1361 1.781, 2.373 -0.55
DBA/2J m 3.1654 0.33853   5 0.15139 0.1069 2.775, 3.583 -0.02
NOD/ShiLtJ f 2.3478 0.33244   10 0.10513 0.1416 1.891, 2.828 -0.23
NOD/ShiLtJ m 3.331 0.31221   5 0.13963 0.0937 2.968, 3.775 0.13
NZO/HlLtJ f 4.3948 0.33159   5 0.14829 0.0755 3.983, 4.752 1.85
NZO/HlLtJ m 4.696 0.0   1   0.0 0.0 4.696, 4.696 1.35
PWK/PhJ f 2.7905 0.3353   4 0.16765 0.1202 2.512, 3.257 0.22
PWK/PhJ m 2.3998 0.12819   5 0.05733 0.0534 2.204, 2.546 -0.71
WSB/EiJ f 1.299 0.41618   3 0.24028 0.3204 0.82, 1.572 -1.3
WSB/EiJ m 1.887 0.58345   5 0.26093 0.3092 1.218, 2.574 -1.17


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3.881 0.1556228712 4.1927500723 3.5692499277
129S1/SvImJ m 4.3285 0.2460613645 4.8214201447 3.8355798553
A/J f 2.12125 0.1739916594 2.4697971769 1.7727028231
A/J m 2.446 0.1556228712 2.7577500723 2.1342499277
C57BL/6J f 2.428 0.2009082628 2.8304676128 2.0255323872
C57BL/6J m 4.539 0.1739916594 4.8875471769 4.1904528231
CAST/EiJ f 1.9014 0.1556228712 2.2131500723 1.5896499277
CAST/EiJ m 1.923 0.2460613645 2.4159201447 1.4300798553
DBA/2J f 2.0392 0.1556228712 2.3509500723 1.7274499277
DBA/2J m 3.1654 0.1556228712 3.4771500723 2.8536499277
NOD/ShiLtJ f 2.3478 0.1100419875 2.5682405902 2.1273594098
NOD/ShiLtJ m 3.331 0.1556228712 3.6427500723 3.0192499277
PWK/PhJ f 2.7905 0.1739916594 3.1390471769 2.4419528231
PWK/PhJ m 2.3998 0.1556228712 2.7115500723 2.0880499277
WSB/EiJ f 1.299 0.2009082628 1.7014676128 0.8965323872
WSB/EiJ m 1.887 0.1556228712 2.1987500723 1.5752499277


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 4.10475 0.1455718664 4.3963654903 3.8131345097
A/J both 2.283625 0.1167171534 2.5174375543 2.0498124457
C57BL/6J both 3.4835 0.1328883249 3.7497073035 3.2172926965
CAST/EiJ both 1.9122 0.1455718664 2.2038154903 1.6205845097
DBA/2J both 2.6023 0.1100419875 2.8227405902 2.3818594098
NOD/ShiLtJ both 2.8394 0.0952991567 3.0303071511 2.6484928489
PWK/PhJ both 2.59515 0.1167171534 2.8289625543 2.3613374457
WSB/EiJ both 1.593 0.1270655422 1.8475428682 1.3384571318




  GWAS USING LINEAR MIXED MODELS