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Project measure / variable:   Auwerx2   iron_HFD

ID, description, units MPD:114678   iron_HFD   plasma iron amount   [mmol/L]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 21wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma iron amount HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means22.092   mmol/L 18.603   mmol/L
Median of the strain means22.9   mmol/L 19.68   mmol/L
SD of the strain means± 4.6606 ± 6.488
Coefficient of variation (CV)0.211 0.3488
Min–max range of strain means13.975   –   28.32   mmol/L 8.42   –   27.6   mmol/L
Mean sample size per strain4.9   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 556.7864 556.7864 24.2044 < 0.0001
strain 7 1243.3034 177.6148 7.7212 < 0.0001
sex:strain 7 371.6199 53.0886 2.3078 0.0386
Residuals 56 1288.1992 23.0036


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 28.32 6.3239   5 2.8281 0.2233 23.4, 37.3 1.34
129S1/SvImJ m 25.85 2.4749   2   1.75 0.0957 24.1, 27.6 1.12
A/J f 13.975 5.6647   4 2.8324 0.4053 7.3, 20.8 -1.74
A/J m 15.36 5.7357   5 2.5651 0.3734 8.7, 23.7 -0.5
C57BL/6J f 16.2 0.7   3 0.40415 0.0432 15.4, 16.7 -1.26
C57BL/6J m 12.55 3.3471   4 1.6736 0.2667 9.0, 16.1 -0.93
CAST/EiJ f 22.9 3.3392   5 1.4933 0.1458 18.8, 26.5 0.17
CAST/EiJ m 13.75 4.0305   2   2.85 0.2931 10.9, 16.6 -0.75
DBA/2J f 24.1 3.0749   5 1.3751 0.1276 20.9, 28.5 0.43
DBA/2J m 19.68 5.8666   5 2.6236 0.2981 13.9, 27.8 0.17
NOD/ShiLtJ f 23.75 2.5461   10 0.80516 0.1072 18.6, 28.1 0.36
NOD/ShiLtJ m 23.36 8.6518   5 3.8692 0.3704 8.6, 31.2 0.73
NZO/HlLtJ f 20.32 3.8114   5 1.7045 0.1876 16.4, 26.6 -0.38
NZO/HlLtJ m 27.6 0.0   1   0.0 0.0 27.6, 27.6 1.39
PWK/PhJ f 22.3 3.2995   4 1.6497 0.148 17.5, 25.0 0.04
PWK/PhJ m 8.42 3.2507   5 1.4538 0.3861 4.0, 12.4 -1.57
WSB/EiJ f 26.967 6.5577   3 3.7861 0.2432 19.4, 31.0 1.05
WSB/EiJ m 20.86 5.1145   5 2.2873 0.2452 14.6, 26.4 0.35


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 28.32 2.1449268774 32.6168048598 24.0231951402
129S1/SvImJ m 25.85 3.3914271736 32.6438450092 19.0561549908
A/J f 13.975 2.3981011524 18.7789738763 9.1710261237
A/J m 15.36 2.1449268774 19.6568048598 11.0631951402
C57BL/6J f 16.2 2.7690886917 21.7471512213 10.6528487787
C57BL/6J m 12.55 2.3981011524 17.3539738763 7.7460261237
CAST/EiJ f 22.9 2.1449268774 27.1968048598 18.6031951402
CAST/EiJ m 13.75 3.3914271736 20.5438450092 6.9561549908
DBA/2J f 24.1 2.1449268774 28.3968048598 19.8031951402
DBA/2J m 19.68 2.1449268774 23.9768048598 15.3831951402
NOD/ShiLtJ f 23.75 1.5166923402 26.7882998538 20.7117001462
NOD/ShiLtJ m 23.36 2.1449268774 27.6568048598 19.0631951402
PWK/PhJ f 22.3 2.3981011524 27.1039738763 17.4960261237
PWK/PhJ m 8.42 2.1449268774 12.7168048598 4.1231951402
WSB/EiJ f 26.9666666667 2.7690886917 32.513817888 21.4195154453
WSB/EiJ m 20.86 2.1449268774 25.1568048598 16.5631951402


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 27.085 2.0063953738 31.1042929108 23.0657070892
A/J both 14.6675 1.6086951581 17.8901036449 11.4448963551
C57BL/6J both 14.375 1.8315800091 18.0440956541 10.7059043459
CAST/EiJ both 18.325 2.0063953738 22.3442929108 14.3057070892
DBA/2J both 21.89 1.5166923402 24.9282998538 18.8517001462
NOD/ShiLtJ both 23.555 1.3134940963 26.1862448577 20.9237551423
PWK/PhJ both 15.36 1.6086951581 18.5826036449 12.1373963551
WSB/EiJ both 23.9133333333 1.7513254618 27.4216598103 20.4050068564




  GWAS USING LINEAR MIXED MODELS