Project measure / variable:   Auwerx2   ALAT_HFD

ID, description, units MPD:114672   ALAT_HFD   plasma alanine transaminase amount (ALAT)   [U/L]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 21wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma alanine transaminase amount (ALAT) HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means66.37   U/L 56.66   U/L
Median of the strain means51.33   U/L 49.0   U/L
SD of the strain means± 48.946 ± 21.942
Coefficient of variation (CV)0.7374 0.3873
Min–max range of strain means34.6   –   193.0   U/L 30.75   –   92.75   U/L
Mean sample size per strain4.9   mice 3.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 469.5118 469.5118 0.4323 0.5136
strain 7 51933.0983 7419.014 6.8317 < 0.0001
sex:strain 7 44371.5664 6338.7952 5.837 < 0.0001
Residuals 55 59728.1333 1085.9661


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 43.0 13.398   5 5.9917 0.3116 32.0, 65.0 -0.48
129S1/SvImJ m 49.0 11.314   2   8.0 0.2309 41.0, 57.0 -0.35
A/J f 65.0 16.793   4 8.3964 0.2584 43.0, 82.0 -0.03
A/J m 47.0 4.6904   5 2.0976 0.0998 41.0, 54.0 -0.44
C57BL/6J f 51.33 8.5049   3 4.9103 0.1657 43.0, 60.0 -0.31
C57BL/6J m 92.75 79.83   4 39.915 0.8607 20.0, 206.0 1.65
CAST/EiJ f 47.6 11.502   5 5.1439 0.2416 32.0, 62.0 -0.38
CAST/EiJ m 44.0 7.0711   2   5.0 0.1607 39.0, 49.0 -0.58
DBA/2J f 34.6 11.739   5 5.2498 0.3393 14.0, 42.0 -0.65
DBA/2J m 33.8 8.228   5 3.6797 0.2434 23.0, 42.0 -1.04
NOD/ShiLtJ f 37.1 13.964   10 4.4158 0.3764 19.0, 69.0 -0.6
NOD/ShiLtJ m 30.75 6.2915   4 3.1458 0.2046 26.0, 40.0 -1.18
NZO/HlLtJ f 70.4 11.824   5 5.2877 0.168 53.0, 85.0 0.08
NZO/HlLtJ m 77.0 0.0   1   0.0 0.0 77.0, 77.0 0.93
PWK/PhJ f 193.0 48.062   4 24.031 0.249 150.0, 261.0 2.59
PWK/PhJ m 54.0 24.9   5 11.136 0.4611 36.0, 97.0 -0.12
WSB/EiJ f 55.33 11.59   3 6.6916 0.2095 43.0, 66.0 -0.23
WSB/EiJ m 81.6 80.2   5 35.869 0.9829 18.0, 221.0 1.14


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 43.0 14.7374764502 72.5345627989 13.4654372011
129S1/SvImJ m 49.0 23.3019962729 95.698244071 2.301755929
A/J f 65.0 16.4769995798 98.0206450521 31.9793549479
A/J m 47.0 14.7374764502 76.5345627989 17.4654372011
C57BL/6J f 51.3333333333 19.0260002856 89.4622899526 13.2043767141
C57BL/6J m 92.75 16.4769995798 125.7706450521 59.7293549479
CAST/EiJ f 47.6 14.7374764502 77.1345627989 18.0654372011
CAST/EiJ m 44.0 23.3019962729 90.698244071 -2.698244071
DBA/2J f 34.6 14.7374764502 64.1345627989 5.0654372011
DBA/2J m 33.8 14.7374764502 63.3345627989 4.2654372011
NOD/ShiLtJ f 37.1 10.4209695355 57.9840896345 16.2159103655
NOD/ShiLtJ m 30.75 16.4769995798 63.7706450521 -2.2706450521
PWK/PhJ f 193.0 16.4769995798 226.0206450521 159.9793549479
PWK/PhJ m 54.0 14.7374764502 83.5345627989 24.4654372011
WSB/EiJ f 55.3333333333 19.0260002856 93.4622899526 17.2043767141
WSB/EiJ m 81.6 14.7374764502 111.1345627989 52.0654372011


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 46.0 13.7856469056 73.6270537654 18.3729462346
A/J both 56.0 11.0531073377 78.1509220992 33.8490779008
C57BL/6J both 72.0416666667 12.5845163 97.2616009079 46.8217324254
CAST/EiJ both 45.8 13.7856469056 73.4270537654 18.1729462346
DBA/2J both 34.2 10.4209695355 55.0840896345 13.3159103655
NOD/ShiLtJ both 33.925 9.74792441 53.4602770618 14.3897229382
PWK/PhJ both 123.5 11.0531073377 145.6509220992 101.3490779008
WSB/EiJ both 68.4666666667 12.0330991331 92.5815362112 44.3517971221




  GWAS USING LINEAR MIXED MODELS