Project measure / variable:   Auwerx2   vco2_max_treadmill_CD

ID, description, units MPD:114643   vco2_max_treadmill_CD   maximum carbon dioxide production, treadmill test   [mL/kg/min]  CD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 19wks
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  STRAIN COMPARISON PLOT
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Auwerx2 - maximum carbon dioxide production, treadmill test CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means124.9   mL/kg/min 114.7   mL/kg/min
Median of the strain means129.8   mL/kg/min 112.1   mL/kg/min
SD of the strain means± 20.932 ± 19.683
Coefficient of variation (CV)0.1676 0.1717
Min–max range of strain means92.04   –   155.2   mL/kg/min 87.8   –   148.8   mL/kg/min
Mean sample size per strain4.2   mice 4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1579.1657 1579.1657 8.1896 0.0058
strain 7 26878.6102 3839.8015 19.9133 < 0.0001
sex:strain 7 1344.3264 192.0466 0.996 0.4433
Residuals 59 11376.7481 192.8262


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 111.9 18.6   5 8.3183 0.1662 88.7, 135.4 -0.62
129S1/SvImJ m 99.97 8.1098   5 3.6268 0.0811 91.74, 112.0 -0.75
A/J f 92.04 3.7475   4 1.8738 0.0407 87.85, 96.79 -1.57
A/J m 87.8 7.6452   3 4.4139 0.0871 78.98, 92.59 -1.36
C57BL/6J f 136.2 17.694   5 7.9131 0.1299 120.8, 161.7 0.54
C57BL/6J m 112.1 8.55   5 3.8237 0.0762 102.5, 125.3 -0.13
CAST/EiJ f 130.5 0.0   1   0.0 0.0 130.5, 130.5 0.27
CAST/EiJ m 125.4 9.3183   3 5.3799 0.0743 116.8, 135.3 0.55
DBA/2J f 129.8 15.546   5 6.9525 0.1198 116.7, 155.4 0.24
DBA/2J m 124.6 14.862   5 6.6465 0.1193 99.84, 136.4 0.51
NOD/ShiLtJ f 112.7 7.0304   6 2.8702 0.0624 101.6, 122.9 -0.58
NOD/ShiLtJ m 109.1 6.2968   5 2.816 0.0577 101.6, 117.4 -0.28
NZO/HlLtJ f 105.5 9.2599   4 4.6299 0.0878 96.22, 116.8 -0.93
NZO/HlLtJ m 92.95 2.6777   5 1.1975 0.0288 90.57, 97.38 -1.1
PWK/PhJ f 155.2 18.947   5 8.4734 0.1221 138.7, 178.5 1.45
PWK/PhJ m 131.2 15.665   5 7.0058 0.1194 117.3, 152.4 0.84
WSB/EiJ f 150.0 16.105   3 9.2983 0.1073 131.7, 161.9 1.2
WSB/EiJ m 148.8 25.238   5 11.287 0.1696 123.4, 189.6 1.73


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 111.9 6.2100924204 124.3263662307 99.4736337693
129S1/SvImJ m 99.974 6.2100924204 112.4003662307 87.5476337693
A/J f 92.0425 6.9430943993 105.9355998026 78.1494001974
A/J m 87.7966666667 8.0171948409 103.8390364885 71.7542968448
C57BL/6J f 136.18 6.2100924204 148.6063662307 123.7536337693
C57BL/6J m 112.14 6.2100924204 124.5663662307 99.7136337693
DBA/2J f 129.76 6.2100924204 142.1863662307 117.3336337693
DBA/2J m 124.588 6.2100924204 137.0143662307 112.1616337693
NOD/ShiLtJ f 112.7333333333 5.6690128381 124.0770018207 101.389664846
NOD/ShiLtJ m 109.1 6.2100924204 121.5263662307 96.6736337693
NZO/HlLtJ f 105.525 6.9430943993 119.4180998026 91.6319001974
NZO/HlLtJ m 92.948 6.2100924204 105.3743662307 80.5216337693
PWK/PhJ f 155.2 6.2100924204 167.6263662307 142.7736337693
PWK/PhJ m 131.18 6.2100924204 143.6063662307 118.7536337693
WSB/EiJ f 150.0333333333 8.0171948409 166.0757031552 133.9909635115
WSB/EiJ m 148.8 6.2100924204 161.2263662307 136.3736337693


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 105.937 4.3911984623 114.7237678273 97.1502321727
A/J both 89.9195833333 5.3028759403 100.5306135805 79.3085530861
C57BL/6J both 124.16 4.3911984623 132.9467678273 115.3732321727
DBA/2J both 127.174 4.3911984623 135.9607678273 118.3872321727
NOD/ShiLtJ both 110.9166666667 4.2042524433 119.3293563741 102.5039769593
NZO/HlLtJ both 99.2365 4.6575693153 108.5562746731 89.9167253269
PWK/PhJ both 143.19 4.3911984623 151.9767678273 134.4032321727
WSB/EiJ both 149.4166666667 5.0705192285 159.5627522074 139.2705811259




  GWAS USING LINEAR MIXED MODELS